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has1 has1 NFIA_105520 NFIA_105520 NFIA_107230 NFIA_107230 nop7 nop7 ytm1 ytm1 NFIA_108630 NFIA_108630 NFIA_108660 NFIA_108660 NFIA_108710 NFIA_108710 NFIA_109140 NFIA_109140 NFIA_109800 NFIA_109800 NFIA_109890 NFIA_109890 NFIA_110280 NFIA_110280 nop16 nop16 NFIA_034100 NFIA_034100 NFIA_034350 NFIA_034350 NFIA_034930 NFIA_034930 NFIA_035110 NFIA_035110 NFIA_035690 NFIA_035690 NFIA_036600 NFIA_036600 NFIA_036610 NFIA_036610 NFIA_036930 NFIA_036930 TIF6 TIF6 NFIA_037200 NFIA_037200 NFIA_038120 NFIA_038120 NFIA_038230 NFIA_038230 NFIA_039020 NFIA_039020 NFIA_040340 NFIA_040340 NFIA_008440 NFIA_008440 NFIA_009110 NFIA_009110 rok1 rok1 NFIA_009710 NFIA_009710 NFIA_010380 NFIA_010380 drs1 drs1 NFIA_010840 NFIA_010840 NFIA_011200 NFIA_011200 NFIA_011240 NFIA_011240 NFIA_012310 NFIA_012310 NFIA_012450 NFIA_012450 NFIA_014470 NFIA_014470 NFIA_014640 NFIA_014640 NFIA_014880 NFIA_014880 NFIA_015090 NFIA_015090 NFIA_015230 NFIA_015230 utp25 utp25 NFIA_016430 NFIA_016430 erb1 erb1 NFIA_018090 NFIA_018090 NFIA_018310 NFIA_018310 NFIA_018420 NFIA_018420 NFIA_018480 NFIA_018480 rrp3 rrp3 NFIA_018520 NFIA_018520 NFIA_019350 NFIA_019350 NAT10 NAT10 NFIA_019920 NFIA_019920 NFIA_020520 NFIA_020520 NFIA_021920 NFIA_021920 NFIA_021990 NFIA_021990 NFIA_022010 NFIA_022010 NFIA_022440 NFIA_022440 NFIA_022450 NFIA_022450 NFIA_022660 NFIA_022660 plyF plyF NFIA_063490 NFIA_063490 nop58 nop58 spb4 spb4 nop9 nop9 dbp8 dbp8 NFIA_067550 NFIA_067550 NFIA_067690 NFIA_067690 nsa2 nsa2 NFIA_069760 NFIA_069760 NFIA_070680 NFIA_070680 NFIA_070950 NFIA_070950 NFIA_071240 NFIA_071240 NFIA_071390 NFIA_071390 NFIA_071700 NFIA_071700 NFIA_114930 NFIA_114930 NFIA_115320 NFIA_115320 NFIA_096450 NFIA_096450 NFIA_096950 NFIA_096950 NFIA_097130 NFIA_097130 NFIA_097430 NFIA_097430 NFIA_097590 NFIA_097590 NFIA_098170 NFIA_098170 NFIA_025190 NFIA_025190 NFIA_025410 NFIA_025410 NFIA_025650 NFIA_025650 NFIA_026670 NFIA_026670 NFIA_027720 NFIA_027720 NFIA_073590 NFIA_073590 NFIA_074970 NFIA_074970 SPB1 SPB1 NFIA_075550 NFIA_075550 dbp7 dbp7 NFIA_076390 NFIA_076390 NFIA_077180 NFIA_077180 NFIA_079620 NFIA_079620 NFIA_080740 NFIA_080740 NFIA_081200 NFIA_081200 NFIA_081520 NFIA_081520 NFIA_082160 NFIA_082160 NFIA_082270 NFIA_082270 NFIA_082650 NFIA_082650 NFIA_082670 NFIA_082670 NFIA_083960 NFIA_083960 NFIA_084610 NFIA_084610 NFIA_084760 NFIA_084760 NFIA_086650 NFIA_086650 NFIA_086760 NFIA_086760 NFIA_087050 NFIA_087050 NFIA_087330 NFIA_087330 NFIA_088060 NFIA_088060 NFIA_088070 NFIA_088070 NFIA_088770 NFIA_088770 dbp9 dbp9 NFIA_089280 NFIA_089280 NFIA_091300 NFIA_091300 NFIA_092050 NFIA_092050 esf2 esf2 NFIA_092120 NFIA_092120 NFIA_092340 NFIA_092340 NFIA_092360 NFIA_092360 NFIA_092370 NFIA_092370 NFIA_006390 NFIA_006390 NFIA_006560 NFIA_006560 ipi1 ipi1 NFIA_050090 NFIA_050090 NFIA_050780 NFIA_050780 NFIA_050860 NFIA_050860 rrp36 rrp36 loc1 loc1 NFIA_051880 NFIA_051880 NFIA_052010 NFIA_052010 NFIA_052070 NFIA_052070 NFIA_053840 NFIA_053840 NFIA_053890 NFIA_053890 mak5 mak5 NFIA_055540 NFIA_055540 NFIA_056100 NFIA_056100 dbp4 dbp4 dbp10 dbp10 NFIA_058860 NFIA_058860 utp10 utp10 NFIA_060140 NFIA_060140
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
has1ATP-dependent RNA helicase has1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (622 aa)
NFIA_105520Small nucleolar ribonucleoprotein complex component (Utp5), putative. (853 aa)
NFIA_107230Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (560 aa)
nop7Pescadillo homolog; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (675 aa)
ytm1Ribosome biogenesis protein ytm1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (488 aa)
NFIA_10863060S ribosome biogenesis protein Mak11, putative. (516 aa)
NFIA_108660Small nucleolar ribonucleoprotein complex subunit, putative. (975 aa)
NFIA_108710Small nucleolar ribonucleoprotein complex subunit, putative. (635 aa)
NFIA_109140Dual specificity phosphatase, putative. (349 aa)
NFIA_109800Ribosomal biogenesis protein Gar2. (477 aa)
NFIA_109890Ribosome biogenesis (Nop4), putative. (732 aa)
NFIA_110280U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family. (693 aa)
nop16Nucleolar protein 16; Involved in the biogenesis of the 60S ribosomal subunit. (241 aa)
NFIA_034100Small nucleolar ribonucleoprotein complex subunit Utp15, putative. (542 aa)
NFIA_034350Nuclear protein (Sgd1), putative. (851 aa)
NFIA_034930Casein kinase I, putative; Belongs to the protein kinase superfamily. (403 aa)
NFIA_03511060S ribosomal protein L24b. (188 aa)
NFIA_035690PINc domain-containing protein. (215 aa)
NFIA_036600Low-temperature viability protein ltv1. (496 aa)
NFIA_036610Ribosome biogenesis GTPase Lsg1, putative. (675 aa)
NFIA_036930Uncharacterized protein. (296 aa)
TIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (247 aa)
NFIA_037200RNA processing factor 1. (444 aa)
NFIA_03812020S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family. (441 aa)
NFIA_038230Uncharacterized protein. (300 aa)
NFIA_039020Small nucleolar ribonucleoprotein complex subunit (Pwp2), putative. (986 aa)
NFIA_040340Nucleolar RNA methyltransferase (Nop2), putative; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (750 aa)
NFIA_008440DEAD/DEAH box helicase, putative. (863 aa)
NFIA_009110Ribosome assembly protein Noc2, putative. (789 aa)
rok1ATP-dependent RNA helicase rok1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (738 aa)
NFIA_009710DEAD box RNA helicase HelA, putative; Belongs to the DEAD box helicase family. (662 aa)
NFIA_010380Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (748 aa)
drs1ATP-dependent RNA helicase drs1; ATP-binding RNA helicase involved in ribosome assembly. (819 aa)
NFIA_010840U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (292 aa)
NFIA_011200Fibrillarin. (313 aa)
NFIA_011240Methyltransferase (Ncl1), putative; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (886 aa)
NFIA_012310Urb2 domain-containing protein. (1480 aa)
NFIA_012450U3 small nucleolar ribonucleoprotein protein IMP4, putative. (299 aa)
NFIA_014470Sas10/Utp3 family protein. (659 aa)
NFIA_014640Ribosomal RNA processing protein, putative. (325 aa)
NFIA_014880CCAAT-box-binding transcription factor. (1113 aa)
NFIA_015090GTP-binding protein. (557 aa)
NFIA_015230PUM-HD domain-containing protein. (695 aa)
utp25U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2. (728 aa)
NFIA_016430AAA family ATPase/60S ribosome export protein Rix7, putative. (736 aa)
erb1Ribosome biogenesis protein erb1; Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (790 aa)
NFIA_01809060S ribosome biogenesis protein Rrp14, putative. (540 aa)
NFIA_018310Helicase, putative. (219 aa)
NFIA_018420Small nucleolar ribonucleoprotein complex subunit (SOF1), putative. (457 aa)
NFIA_018480Ribosome biogenesis protein Ssf2, putative. (445 aa)
rrp3ATP-dependent rRNA helicase rrp3; ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA. (472 aa)
NFIA_018520Protein arginine n-methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (352 aa)
NFIA_019350Ribosome biogenesis protein Kri1. (617 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1066 aa)
NFIA_019920Pre-rRNA processing protein Mrd1, putative. (825 aa)
NFIA_020520Small nucleolar ribonucleoprotein complex subunit Utp14, putatrive. (963 aa)
NFIA_021920WD domain protein. (962 aa)
NFIA_021990rRNA processing protein Pwp1, putative. (542 aa)
NFIA_022010rRNA processing protein, putative. (327 aa)
NFIA_02244060S ribosome biogenesis protein Brx1, putative. (356 aa)
NFIA_022450F-box domain protein. (357 aa)
NFIA_022660WD repeat protein. (515 aa)
plyFProbable pectate lyase F; Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester (By similarity); Belongs to the polysaccharide lyase 3 family. (234 aa)
NFIA_063490AB hydrolase-1 domain-containing protein. (343 aa)
nop58Nucleolar protein 58; Required for pre-18S rRNA processing. May bind microtubules (By similarity); Belongs to the NOP5/NOP56 family. (591 aa)
spb4ATP-dependent rRNA helicase spb4; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2. (640 aa)
nop9Nucleolar protein 9; RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit (By similarity); Belongs to the NOP9 family. (699 aa)
dbp8ATP-dependent RNA helicase dbp8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. (526 aa)
NFIA_067550Uncharacterized protein. (396 aa)
NFIA_067690Pre-rRNA processing nucleolar protein Sik1, putative. (516 aa)
nsa2Ribosome biogenesis protein nsa2; Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity). (271 aa)
NFIA_069760Protein kinase domain-containing protein. (241 aa)
NFIA_070680WD repeat protein. (577 aa)
NFIA_070950RNA binding protein. (330 aa)
NFIA_071240RNA processing protein Emg1, putative. (254 aa)
NFIA_071390RNA binding protein Rnp24, putative. (372 aa)
NFIA_071700U3 small nucleolar RNA-associated protein 22. (1113 aa)
NFIA_114930Uncharacterized protein. (315 aa)
NFIA_115320Uncharacterized protein. (693 aa)
NFIA_096450rRNA-processing protein; Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit. Belongs to the CGR1 family. (114 aa)
NFIA_096950rRNA maturation protein (Nop14), putative. (914 aa)
NFIA_097130RNA binding protein, putative. (537 aa)
NFIA_097430RNA-3'-phosphate cyclase family protein. (403 aa)
NFIA_097590Ribosome biogenesis protein, putative. (330 aa)
NFIA_098170Ribosome biogenesis protein Noc4, putative. (551 aa)
NFIA_025190Uncharacterized protein. (223 aa)
NFIA_025410Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (220 aa)
NFIA_025650Conserved hypothetical portein. (525 aa)
NFIA_026670Uncharacterized protein. (404 aa)
NFIA_027720BNR/Asp-box repeat protein, putative. (364 aa)
NFIA_073590Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (247 aa)
NFIA_074970rRNA processing protein (Ebp2), putative. (381 aa)
SPB1AdoMet-dependent rRNA methyltransferase SPB1; Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily. (794 aa)
NFIA_075550RIO1 family protein kinase, putative. (374 aa)
dbp7ATP-dependent RNA helicase dbp7; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs. (758 aa)
NFIA_076390Uncharacterized protein. (1124 aa)
NFIA_077180Dual specificity phosphatase Yvh1, putative. (263 aa)
NFIA_079620RNA 3'-terminal phosphate cyclase, putative. (452 aa)
NFIA_080740Small nucleolar ribonucleoprotein complex subunit, putative. (977 aa)
NFIA_081200C2H2 finger domain protein, putative. (442 aa)
NFIA_081520WD repeat protein. (718 aa)
NFIA_082160Pre-rRNA processing protein Esf1, putative. (729 aa)
NFIA_082270Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (430 aa)
NFIA_082650Small nucleolar ribonucleoprotein complex subunit, putative. (619 aa)
NFIA_082670Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (126 aa)
NFIA_083960U3 small nucleolar ribonucleoprotein subunit (Imp3), putative. (188 aa)
NFIA_084610Arginine N-methyltransferase 2; S-adenosyl-L-methionine-dependent protein-arginine N- methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12. (425 aa)
NFIA_084760ATP-dependent RNA helicase (Hrh1), putative. (821 aa)
NFIA_086650KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (358 aa)
NFIA_086760Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (655 aa)
NFIA_087050Pre-rRNA processing protein Rrp12, putative. (1270 aa)
NFIA_087330Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (4926 aa)
NFIA_088060Pre-rRNA processing protein Tsr1, putative. (803 aa)
NFIA_088070Small nucleolar ribonucleoprotein complex subunit, putative. (528 aa)
NFIA_088770Ribosome biogenesis protein (Bms1), putative. (1183 aa)
dbp9ATP-dependent RNA helicase dbp9; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily. (619 aa)
NFIA_089280Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (565 aa)
NFIA_091300rRNA biogenesis protein RRP5, putative. (1819 aa)
NFIA_09205060S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (532 aa)
esf2Pre-rRNA-processing protein esf2; Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity); Belongs to the ESF2/ABP1 family. (365 aa)
NFIA_092120Curved DNA-binding protein (42 kDa protein). (405 aa)
NFIA_092340PT repeat family protein. (1762 aa)
NFIA_092360Nucleolar complex-associated protein 3; Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm. Belongs to the CBF/MAK21 family. (692 aa)
NFIA_09237060S ribosome subunit biogenesis protein NIP7; Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly; Belongs to the NIP7 family. (194 aa)
NFIA_006390rRNA processing protein Bystin, putative. (498 aa)
NFIA_006560SnoRNA binding protein, putative. (1005 aa)
ipi1Pre-rRNA-processing protein ipi1; Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA. (345 aa)
NFIA_050090mRNA-nucleus export ATPase (Elf1), putative. (1110 aa)
NFIA_050780Protein MAK16; Belongs to the MAK16 family. (324 aa)
NFIA_050860DEAH-box RNA helicase (Dhr1), putative. (1210 aa)
rrp36rRNA biogenesis protein rrp36; Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity). (356 aa)
loc160S ribosomal subunit assembly/export protein loc1; Required for efficient assembly and nuclear export of the 60S ribosomal subunit. (190 aa)
NFIA_051880Nucleolus protein required for cell viability, putative. (241 aa)
NFIA_052010Methyltransferase, putative. (245 aa)
NFIA_052070rRNA processing protein (Rrp20), putative. (260 aa)
NFIA_053840DNA polymerase V, putative. (974 aa)
NFIA_053890HEAT repeat protein (DRIM), putative. (2615 aa)
mak5ATP-dependent RNA helicase mak5; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily. (777 aa)
NFIA_055540Transcription factor AATF/Che-1, putative. (562 aa)
NFIA_056100Ribosome biogenesis protein (Rrb1), putative. (496 aa)
dbp4ATP-dependent RNA helicase dbp4; ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity). (810 aa)
dbp10ATP-dependent RNA helicase dbp10; ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (934 aa)
NFIA_058860C2H2 finger domain protein, putative. (111 aa)
utp10U3 small nucleolar RNA-associated protein 10; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity). (1814 aa)
NFIA_060140U3 small nucleolar ribonucleoprotein protein Lcp5, putative. (394 aa)
Your Current Organism:
Aspergillus fischeri
NCBI taxonomy Id: 331117
Other names: A. fischeri NRRL 181, Aspergillus fischeri NRRL 181, Neosartorya fischeri NRRL 181
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