(58 nodes) Nucleic acid-binding, OB-fold network (Aspergillus fischeri)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NFIA_020660	Eukaryotic translation initiation factor 5A. (157 aa)
	NFIA_020280	Lysine--tRNA ligase. (467 aa)
	NFIA_018540	Proteasome regulatory particle subunit Rpt5, putative; Belongs to the AAA ATPase family. (464 aa)
	NFIA_018270	Uncharacterized protein. (147 aa)
	NFIA_016170	Ribosomal protein S23 (S12); Belongs to the universal ribosomal protein uS12 family. (145 aa)
	NFIA_014160	Cell wall biogenesis protein phosphatase Ssd1, putative. (1376 aa)
	NFIA_039560	DNA helicase; Belongs to the MCM family. (718 aa)
	NFIA_038740	Telo_bind domain-containing protein. (1382 aa)
	NFIA_036770	60S ribosomal protein L8, putative. (254 aa)
	NFIA_034990	Aspartyl-tRNA synthetase Dps1, putative. (555 aa)
	NFIA_034710	Exosome complex exonuclease Rrp40, putative. (274 aa)
	NFIA_104090	50S ribosomal protein L2. (404 aa)
	NFIA_104020	Exosome complex exonuclease exoribonuclease (Rrp44), putative; Belongs to the RNR ribonuclease family. (1034 aa)
	NFIA_039650	ATP-dependent DNA ligase, putative. (1068 aa)
	NFIA_058900	Uncharacterized protein. (218 aa)
	NFIA_056830	Possible replication factor-a protein. (338 aa)
	NFIA_053310	Lysine--tRNA ligase. (605 aa)
	NFIA_052430	Proteasome regulatory particle subunit Rpt4, putative; Belongs to the AAA ATPase family. (393 aa)
	NFIA_048800	Eukaryotic translation initiation factor eIF-1A subunit, putative; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (149 aa)
	NFIA_091360	Telomere-binding protein alpha subunit, central domain, putative. (635 aa)
	NFIA_091300	rRNA biogenesis protein RRP5, putative. (1819 aa)
	NFIA_091200	Cofactor for methionyl-and glutamyl-tRNA synthetases, putative. (448 aa)
	NFIA_088350	OB-fold nucleic acid binding domain protein. (246 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (814 aa)
	NFIA_084590	DNA helicase; Belongs to the MCM family. (1023 aa)
	NFIA_084560	DNA ligase. (840 aa)
	NFIA_083100	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (603 aa)
	NFIA_082500	mRNA-capping enzyme subunit alpha; Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate; Belongs to the eukaryotic GTase family. (415 aa)
	NFIA_082380	Cytoplasmic asparaginyl-tRNA synthetase, putative. (574 aa)
	NFIA_080930	40S ribosomal protein S11; Belongs to the universal ribosomal protein uS17 family. (160 aa)
	NFIA_080210	Proteasome regulatory particle subunit Rpt2, putative; Belongs to the AAA ATPase family. (523 aa)
	NFIA_079390	SsDNA binding protein, putative. (149 aa)
	NFIA_078470	Woronin body protein HexA, putative. (508 aa)
	NFIA_076480	37S ribosomal protein S12. (193 aa)
	NFIA_076400	RNA helicase-like splicing factor (HRH1), putative. (1230 aa)
	NFIA_076340	DNA helicase; Belongs to the MCM family. (956 aa)
	NFIA_076140	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (145 aa)
	NFIA_075720	tRNA(M5U54)methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (531 aa)
	NFIA_075300	Eukaryotic initiation factor 1A, putative. (137 aa)
	NFIA_075240	DNA ligase. (1023 aa)
	NFIA_074190	Uncharacterized protein. (122 aa)
	NFIA_073520	3'-5' exoribonuclease (Csl4), putative. (249 aa)
	NFIA_025460	Ribosomal protein S28e. (68 aa)
	NFIA_098050	RNA polymerase II subunit 7. (167 aa)
	NFIA_097080	DNA-directed rna polymerase III 25 kD polypeptide. (201 aa)
	NFIA_028690	Proteasome regulatory particle subunit Rpt6, putative; Belongs to the AAA ATPase family. (389 aa)
	NFIA_114260	Mitochondrial exoribonuclease Cyt-4, putative. (1043 aa)
	NFIA_071370	Exosome complex exonuclease Rrp4, putative. (390 aa)
	NFIA_071340	Transcription elongation factor Spt6; Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression; Belongs to the SPT6 family. (1421 aa)
	NFIA_069340	Proteasome regulatory particle subunit Rpt1, putative; Belongs to the AAA ATPase family. (439 aa)
	NFIA_067660	Asparaginyl-tRNA synthetase Slm5, putative. (549 aa)
	NFIA_066990	DNA replication protein, putative. (793 aa)
	NFIA_066120	DNA ligase. (833 aa)
	NFIA_065910	Proteasome regulatory particle subunit Rpt3, putative; Belongs to the AAA ATPase family. (421 aa)
	NFIA_063860	Translation initiation factor 2 alpha subunit, putative. (308 aa)
	NFIA_063270	DNA helicase; Belongs to the MCM family. (844 aa)
	NFIA_022050	Aspartyl-tRNA synthetase, cytoplasmic. (948 aa)
	NFIA_020770	DNA helicase; Belongs to the MCM family. (892 aa)

Your Current Organism:

Aspergillus fischeri

NCBI taxonomy Id: 331117
Other names: A. fischeri NRRL 181, Aspergillus fischeri NRRL 181, Neosartorya fischeri NRRL 181

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCM7	NFIA_020770	A1DGU4	A1D4M6	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	NFIA_039560	A1DGU4	A1D060	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	NFIA_039650	A1DGU4	A1D069	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	ATP-dependent DNA ligase, putative.	0.427
MCM7	NFIA_056830	A1DGU4	A1DNG3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Possible replication factor-a protein.	0.798
MCM7	NFIA_063270	A1DGU4	A1D622	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	NFIA_066120	A1DGU4	A1D6V4	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.616
MCM7	NFIA_066990	A1DGU4	A1D738	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA replication protein, putative.	0.992
MCM7	NFIA_075240	A1DGU4	A1DDY8	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.427
MCM7	NFIA_076340	A1DGU4	A1DE97	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	NFIA_083100	A1DGU4	A1DG52	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.774
MCM7	NFIA_084560	A1DGU4	A1DGJ7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA ligase.	0.707
MCM7	NFIA_084590	A1DGU4	A1DGK0	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
MCM7	NFIA_097080	A1DGU4	A1DB45	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA-directed rna polymerase III 25 kD polypeptide.	0.577
NFIA_014160	NFIA_034710	A1D2T3	A1CYT3	Cell wall biogenesis protein phosphatase Ssd1, putative.	Exosome complex exonuclease Rrp40, putative.	0.420
NFIA_014160	NFIA_071370	A1D2T3	A1D8C2	Cell wall biogenesis protein phosphatase Ssd1, putative.	Exosome complex exonuclease Rrp4, putative.	0.955
NFIA_014160	NFIA_073520	A1D2T3	A1DDH9	Cell wall biogenesis protein phosphatase Ssd1, putative.	3'-5' exoribonuclease (Csl4), putative.	0.961
NFIA_014160	NFIA_091300	A1D2T3	A1DIG4	Cell wall biogenesis protein phosphatase Ssd1, putative.	rRNA biogenesis protein RRP5, putative.	0.577
NFIA_016170	NFIA_020280	A1D3D1	A1D4H7	Ribosomal protein S23 (S12); Belongs to the universal ribosomal protein uS12 family.	Lysine--tRNA ligase.	0.610
NFIA_016170	NFIA_020660	A1D3D1	A1D4L5	Ribosomal protein S23 (S12); Belongs to the universal ribosomal protein uS12 family.	Eukaryotic translation initiation factor 5A.	0.980
NFIA_016170	NFIA_025460	A1D3D1	A1DCB3	Ribosomal protein S23 (S12); Belongs to the universal ribosomal protein uS12 family.	Ribosomal protein S28e.	0.999