(21 nodes) Valine, leucine and isoleucine biosynthesis network (Aspergillus fischeri)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	NFIA_108060	Threonine dehydratase. (588 aa)
	NFIA_108360	L-serine dehydratase. (464 aa)
	NFIA_109010	Mitochondrial acetolactate synthase small subunit, putative. (327 aa)
	NFIA_109980	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (411 aa)
	NFIA_041920	Acetolactate synthase. (663 aa)
	NFIA_042060	Dihydroxy-acid dehydratase (Dad). (624 aa)
	NFIA_009550	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (366 aa)
	NFIA_010410	2-isopropylmalate synthase. (643 aa)
	NFIA_017400	Dihydroxy-acid dehydratase, putative. (607 aa)
	NFIA_018580	L-serine dehydratase, putative. (361 aa)
	NFIA_021110	Mitochondrial dihydroxy acid dehydratase, putative. (608 aa)
	NFIA_022950	Branched-chain amino acid aminotransferase. (379 aa)
	NFIA_062600	Dihydroxy-acid dehydratase (Dad). (541 aa)
	NFIA_062770	Ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family. (396 aa)
	NFIA_062780	Pyridoxal-phosphate dependent enzyme, putative. (385 aa)
	NFIA_066960	Acetolactate synthase. (694 aa)
	NFIA_085800	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (397 aa)
	NFIA_086540	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (777 aa)
	NFIA_089370	Mitochondrial dihydroxy acid dehydratase, putative. (651 aa)
	NFIA_091550	Dihydroxy acid dehydratase, putative. (654 aa)
	NFIA_059550	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (368 aa)

Your Current Organism:

Aspergillus fischeri

NCBI taxonomy Id: 331117
Other names: A. fischeri NRRL 181, Aspergillus fischeri NRRL 181, Neosartorya fischeri NRRL 181

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
NFIA_009550	NFIA_010410	A1D1I2	A1D1R7	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	2-isopropylmalate synthase.	0.596
NFIA_009550	NFIA_018580	A1D1I2	A1D414	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	L-serine dehydratase, putative.	0.911
NFIA_009550	NFIA_041920	A1D1I2	A1D0U4	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Acetolactate synthase.	0.953
NFIA_009550	NFIA_059550	A1D1I2	A1DP80	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.902
NFIA_009550	NFIA_062780	A1D1I2	A1D5X3	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Pyridoxal-phosphate dependent enzyme, putative.	0.911
NFIA_009550	NFIA_066960	A1D1I2	A1D735	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Acetolactate synthase.	0.952
NFIA_009550	NFIA_086540	A1D1I2	A1DH42	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.976
NFIA_009550	NFIA_108060	A1D1I2	A1CXG1	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Threonine dehydratase.	0.911
NFIA_009550	NFIA_108360	A1D1I2	A1CXJ1	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	L-serine dehydratase.	0.911
NFIA_009550	NFIA_109010	A1D1I2	A1CXQ6	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	Mitochondrial acetolactate synthase small subunit, putative.	0.964
NFIA_010410	NFIA_009550	A1D1R7	A1D1I2	2-isopropylmalate synthase.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.596
NFIA_010410	NFIA_017400	A1D1R7	A1D3P6	2-isopropylmalate synthase.	Dihydroxy-acid dehydratase, putative.	0.956
NFIA_010410	NFIA_021110	A1D1R7	A1D4R0	2-isopropylmalate synthase.	Mitochondrial dihydroxy acid dehydratase, putative.	0.962
NFIA_010410	NFIA_022950	A1D1R7	A1D591	2-isopropylmalate synthase.	Branched-chain amino acid aminotransferase.	0.947
NFIA_010410	NFIA_041920	A1D1R7	A1D0U4	2-isopropylmalate synthase.	Acetolactate synthase.	0.890
NFIA_010410	NFIA_042060	A1D1R7	A1D0V8	2-isopropylmalate synthase.	Dihydroxy-acid dehydratase (Dad).	0.962
NFIA_010410	NFIA_059550	A1D1R7	A1DP80	2-isopropylmalate synthase.	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.	0.596
NFIA_010410	NFIA_062600	A1D1R7	A1D5V5	2-isopropylmalate synthase.	Dihydroxy-acid dehydratase (Dad).	0.962
NFIA_010410	NFIA_062770	A1D1R7	A1D5X2	2-isopropylmalate synthase.	Ketol-acid reductoisomerase, mitochondrial; Belongs to the ketol-acid reductoisomerase family.	0.575
NFIA_010410	NFIA_066960	A1D1R7	A1D735	2-isopropylmalate synthase.	Acetolactate synthase.	0.890