STRINGSTRING
NFIA_102670 NFIA_102670 NFIA_102720 NFIA_102720 NFIA_104670 NFIA_104670 NFIA_105810 NFIA_105810 mdm34 mdm34 atg1 atg1 NFIA_109960 NFIA_109960 NFIA_032940 NFIA_032940 NFIA_009350 NFIA_009350 NFIA_009530 NFIA_009530 mdm12 mdm12 hog1 hog1 NFIA_015670 NFIA_015670 atg8 atg8 NFIA_017560 NFIA_017560 NFIA_018920 NFIA_018920 NFIA_020050 NFIA_020050 NFIA_065720 NFIA_065720 NFIA_066180 NFIA_066180 NFIA_068910 NFIA_068910 NFIA_071170 NFIA_071170 NFIA_096530 NFIA_096530 NFIA_097610 NFIA_097610 NFIA_098290 NFIA_098290 mdmB mdmB NFIA_074570 NFIA_074570 mpkc mpkc NFIA_078890 NFIA_078890 NFIA_079790 NFIA_079790 NFIA_085670 NFIA_085670 NFIA_088510 NFIA_088510 mmm1 mmm1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NFIA_102670Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (422 aa)
NFIA_102720WSC domain protein, putative. (287 aa)
NFIA_104670Intermembrane space AAA protease IAP-1. (821 aa)
NFIA_105810Small nuclear ribonucleoprotein Sm D3. (116 aa)
mdm34Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. (572 aa)
atg1Serine/threonine-protein kinase atg1; Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing [...] (950 aa)
NFIA_109960Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (363 aa)
NFIA_032940Osmolarity two-component system protein sln1. (1093 aa)
NFIA_009350MAP kinase kinase (Pbs2), putative. (656 aa)
NFIA_009530Protein phosphatase 2c. (562 aa)
mdm12Mitochondrial distribution and morphology protein 12; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm12 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pat [...] (439 aa)
hog1Mitogen-activated protein kinase hog1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity); Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily. (366 aa)
NFIA_015670Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (294 aa)
atg8Autophagy-related protein 8; Ubiquitin-like modifier involved in autophagosomes formation. With atg4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved [...] (118 aa)
NFIA_017560Ubiquitin carboxyl-terminal hydrolase. (863 aa)
NFIA_018920MAP kinase kinase (Mkk2), putative. (504 aa)
NFIA_020050Uncharacterized protein. (109 aa)
NFIA_065720Taz1-interacting factor 1 (TAF1), putative. (1297 aa)
NFIA_066180Mitogen activated protein kinase kinase kinase 3, mapkkk3, mekk3. (1612 aa)
NFIA_068910MRS7 family protein. (560 aa)
NFIA_071170Multicopy suppressor of stt4 mutation. (880 aa)
NFIA_096530Dynamin-like GTPase Dnm1, putative; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (800 aa)
NFIA_097610Casein kinase, putative; Belongs to the protein kinase superfamily. (336 aa)
NFIA_098290Sin3b. (1506 aa)
mdmBMitochondrial distribution and morphology protein 10; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the recepto [...] (471 aa)
NFIA_074570DNA polymerase gamma. (1109 aa)
mpkcMitogen-activated protein kinase mpkC; Mitogen-activated protein kinase required for growth on media where sorbitol or mannitol is the sole carbon source. (377 aa)
NFIA_078890Response regulator, putative. (888 aa)
NFIA_079790Uncharacterized protein. (185 aa)
NFIA_085670Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2384 aa)
NFIA_088510Mitochondrial fission 1 protein; Has a role in mitochondrial fission. (172 aa)
mmm1Maintenance of mitochondrial morphology protein 1; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta- barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm1 su [...] (496 aa)
Your Current Organism:
Aspergillus fischeri
NCBI taxonomy Id: 331117
Other names: A. fischeri NRRL 181, Aspergillus fischeri NRRL 181, Neosartorya fischeri NRRL 181
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.