(87 nodes) Response to ketone network (Hirundo rustica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DUI87_31927	Inhibitor_Mig-6 domain-containing protein. (439 aa)
	DUI87_05148	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (748 aa)
	DUI87_02968	Uncharacterized protein. (181 aa)
	DUI87_00455	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (288 aa)
	DUI87_02967	Nuclear receptor domain-containing protein. (292 aa)
	DUI87_07033	AC_N domain-containing protein. (312 aa)
	DUI87_04276	TGF_BETA_2 domain-containing protein. (375 aa)
	DUI87_01177	FERM domain-containing protein. (605 aa)
	DUI87_03190	Protein kinase domain-containing protein. (125 aa)
	DUI87_04627	AC_N domain-containing protein. (338 aa)
	DUI87_10109	Uncharacterized protein. (66 aa)
	DUI87_04625	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1199 aa)
	DUI87_08269	SERPIN domain-containing protein; Belongs to the serpin family. (386 aa)
	DUI87_04347	Uncharacterized protein. (392 aa)
	DUI87_06593	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (474 aa)
	DUI87_05518	BHLH domain-containing protein. (348 aa)
	DUI87_06511	Uncharacterized protein. (243 aa)
	DUI87_11983	Uncharacterized protein. (192 aa)
	DUI87_05147	Uncharacterized protein; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (729 aa)
	DUI87_05839	Uncharacterized protein; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1728 aa)
	DUI87_06597	Non-specific serine/threonine protein kinase. (529 aa)
	DUI87_08270	SERPIN domain-containing protein; Belongs to the serpin family. (399 aa)
	DUI87_08268	Uncharacterized protein; Belongs to the serpin family. (809 aa)
	DUI87_08751	Uncharacterized protein. (644 aa)
	DUI87_07037	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (759 aa)
	DUI87_07092	Uncharacterized protein. (456 aa)
	DUI87_09899	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	DUI87_08752	NR LBD domain-containing protein. (297 aa)
	DUI87_10622	RWD domain-containing protein. (240 aa)
	DUI87_12546	3Beta_HSD domain-containing protein. (253 aa)
	DUI87_10107	SET domain-containing protein. (255 aa)
	DUI87_16024	Uncharacterized protein. (691 aa)
	DUI87_10146	Uncharacterized protein; Belongs to the cytochrome P450 family. (542 aa)
	DUI87_09961	Uncharacterized protein. (991 aa)
	DUI87_13195	Uncharacterized protein. (357 aa)
	DUI87_12547	3Beta_HSD domain-containing protein. (214 aa)
	DUI87_14791	G_PROTEIN_RECEP_F1_2 domain-containing protein. (223 aa)
	DUI87_12945	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1446 aa)
	DUI87_12935	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (232 aa)
	DUI87_15219	Uncharacterized protein. (548 aa)
	DUI87_15208	FERM domain-containing protein. (633 aa)
	DUI87_14421	Uncharacterized protein. (455 aa)
	DUI87_16396	Uncharacterized protein. (480 aa)
	DUI87_16119	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. (880 aa)
	DUI87_14977	Non-specific serine/threonine protein kinase. (568 aa)
	DUI87_17104	FMN hydroxy acid dehydrogenase domain-containing protein. (849 aa)
	DUI87_17685	AC_N domain-containing protein. (442 aa)
	DUI87_16841	Nuclear receptor domain-containing protein. (733 aa)
	DUI87_16658	Uncharacterized protein. (902 aa)
	DUI87_19149	Uncharacterized protein. (138 aa)
	DUI87_19163	Uncharacterized protein. (153 aa)
	DUI87_17690	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (273 aa)
	DUI87_17688	Guanylate cyclase domain-containing protein. (165 aa)
	DUI87_18417	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (568 aa)
	DUI87_18325	Homeobox domain-containing protein. (347 aa)
	DUI87_17856	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	DUI87_21142	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1053 aa)
	DUI87_23251	TGF_BETA_2 domain-containing protein. (412 aa)
	DUI87_21308	Uncharacterized protein. (1344 aa)
	DUI87_21250	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	DUI87_22479	G_PROTEIN_RECEP_F1_2 domain-containing protein. (352 aa)
	DUI87_23394	Uncharacterized protein. (386 aa)
	DUI87_25331	Uncharacterized protein. (206 aa)
	DUI87_24178	Uncharacterized protein. (354 aa)
	DUI87_26718	Uncharacterized protein. (882 aa)
	DUI87_24746	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (360 aa)
	DUI87_31626	Uncharacterized protein. (324 aa)
	DUI87_25141	Uncharacterized protein. (431 aa)
	DUI87_25108	Uncharacterized protein. (604 aa)
	DUI87_31926	DJ-1_PfpI domain-containing protein. (189 aa)
	DUI87_26918	Uncharacterized protein. (1439 aa)
	DUI87_26746	HTH La-type RNA-binding domain-containing protein. (958 aa)
	DUI87_27982	Uncharacterized protein. (614 aa)
	DUI87_30278	Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Lipocalin family. (205 aa)
	DUI87_27854	BH4_2 domain-containing protein. (257 aa)
	DUI87_27834	BPI2 domain-containing protein. (449 aa)
	DUI87_29172	Uncharacterized protein; Belongs to the peptidase C19 family. (1058 aa)
	DUI87_29120	AB hydrolase-1 domain-containing protein. (525 aa)
	DUI87_28554	Osteocalcin; Binds strongly to apatite and calcium. (101 aa)
	NDOR1	NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (601 aa)
	DUI87_31990	Uncharacterized protein; Belongs to the peptidase C14A family. (417 aa)
	DUI87_31363	Uncharacterized protein. (1037 aa)
	DUI87_31141	TGF_BETA_2 domain-containing protein. (368 aa)
	DUI87_33916	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (490 aa)
	DUI87_31995	Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (152 aa)
	DUI87_33032	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1182 aa)
	DUI87_33065	Uncharacterized protein. (648 aa)

Your Current Organism:

Hirundo rustica

NCBI taxonomy Id: 333673
Other names: H. rustica rustica, Hirundo rustica rustica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUI87_00455	DUI87_04625	A0A3M0LAB9	A0A3M0KZJ6	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.723
DUI87_00455	DUI87_04627	A0A3M0LAB9	A0A3M0L141	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	AC_N domain-containing protein.	0.700
DUI87_00455	DUI87_07033	A0A3M0LAB9	A0A3M0L6J9	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	AC_N domain-containing protein.	0.756
DUI87_00455	DUI87_07037	A0A3M0LAB9	A0A3M0KQJ3	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.769
DUI87_00455	DUI87_13195	A0A3M0LAB9	A0A3M0KCX3	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.798
DUI87_00455	DUI87_17688	A0A3M0LAB9	A0A3M0JXB0	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein.	0.818
DUI87_00455	DUI87_17690	A0A3M0LAB9	A0A3M0JXR4	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.836
DUI87_00455	DUI87_23394	A0A3M0LAB9	A0A3M0JGA9	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.798
DUI87_00455	DUI87_24178	A0A3M0LAB9	A0A3M0JEN4	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.798
DUI87_00455	DUI87_33032	A0A3M0LAB9	A0A3M0IRT6	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.718
DUI87_00455	NDOR1	A0A3M0LAB9	A0A3M0IZV8	Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.	0.480
DUI87_01177	DUI87_12945	A0A3M0L4K8	A0A3M0KAC2	FERM domain-containing protein.	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer.	0.432
DUI87_02967	DUI87_08751	A0A3M0L9P9	A0A3M0KQT5	Nuclear receptor domain-containing protein.	Uncharacterized protein.	0.645
DUI87_02967	DUI87_08752	A0A3M0L9P9	A0A3M0KKT2	Nuclear receptor domain-containing protein.	NR LBD domain-containing protein.	0.645
DUI87_02967	DUI87_16119	A0A3M0L9P9	A0A3M0K6I4	Nuclear receptor domain-containing protein.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.737
DUI87_02967	DUI87_16841	A0A3M0L9P9	A0A3M0K2H7	Nuclear receptor domain-containing protein.	Nuclear receptor domain-containing protein.	0.728
DUI87_02967	DUI87_21142	A0A3M0L9P9	A0A3M0JT86	Nuclear receptor domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.587
DUI87_02968	DUI87_08751	A0A3M0LAQ5	A0A3M0KQT5	Uncharacterized protein.	Uncharacterized protein.	0.645
DUI87_02968	DUI87_08752	A0A3M0LAQ5	A0A3M0KKT2	Uncharacterized protein.	NR LBD domain-containing protein.	0.645
DUI87_02968	DUI87_16119	A0A3M0LAQ5	A0A3M0K6I4	Uncharacterized protein.	Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.	0.737