(43 nodes) Activation of ATR in response to replication stress network (Hirundo rustica)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	DUI87_26479	Uncharacterized protein. (156 aa)
	MCM7-2	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (396 aa)
	DUI87_33245	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa)
	DUI87_31349	Protein kinase domain-containing protein. (767 aa)
	DUI87_33753	Uncharacterized protein. (172 aa)
	DUI87_31620	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa)
	DUI87_32382	Uncharacterized protein. (1315 aa)
	DUI87_32270	RPA_C domain-containing protein. (273 aa)
	DUI87_34619	Uncharacterized protein. (243 aa)
	DUI87_06544	Uncharacterized protein. (319 aa)
	DUI87_35162	Uncharacterized protein. (156 aa)
	DUI87_04756	ORC4_C domain-containing protein. (397 aa)
	MCM7-4	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (242 aa)
	DUI87_04702	Uncharacterized protein. (282 aa)
	DUI87_04701	MCM domain-containing protein; Belongs to the MCM family. (554 aa)
	MCM7-3	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (244 aa)
	DUI87_04326	Uncharacterized protein. (571 aa)
	DUI87_07621	DNA helicase; Belongs to the MCM family. (860 aa)
	DUI87_05659	DNA helicase; Belongs to the MCM family. (811 aa)
	DUI87_14062	Uncharacterized protein. (279 aa)
	DUI87_10807	Uncharacterized protein. (560 aa)
	DUI87_12466	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (755 aa)
	DUI87_13167	AAA_16 domain-containing protein. (450 aa)
	DUI87_12574	AAA domain-containing protein. (401 aa)
	DUI87_13263	Mcm10 domain-containing protein. (1366 aa)
	DUI87_16596	BTB domain-containing protein. (552 aa)
	DUI87_16680	AAA domain-containing protein. (356 aa)
	DUI87_14744	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (272 aa)
	DUI87_15109	RING-type domain-containing protein. (866 aa)
	DUI87_15291	MCM domain-containing protein; Belongs to the MCM family. (948 aa)
	DUI87_16604	BTB domain-containing protein. (537 aa)
	DUI87_18215	Uncharacterized protein. (121 aa)
	DUI87_18133	DBF4-type domain-containing protein. (697 aa)
	DUI87_17331	Uncharacterized protein. (261 aa)
	DUI87_17587	AAA domain-containing protein. (329 aa)
	DUI87_17758	Uncharacterized protein. (223 aa)
	DUI87_21306	Uncharacterized protein. (461 aa)
	DUI87_20274	DNA helicase; Belongs to the MCM family. (807 aa)
	DUI87_21307	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1921 aa)
	DUI87_23490	Uncharacterized protein. (602 aa)
	DUI87_21161	AAA domain-containing protein. (363 aa)
	DUI87_24422	DNA helicase; Belongs to the MCM family. (888 aa)
	DUI87_25555	Uncharacterized protein. (344 aa)

Your Current Organism:

Hirundo rustica

NCBI taxonomy Id: 333673
Other names: H. rustica rustica, Hirundo rustica rustica

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUI87_04326	DUI87_04701	A0A3M0KYR6	A0A3M0L081	Uncharacterized protein.	MCM domain-containing protein; Belongs to the MCM family.	0.994
DUI87_04326	DUI87_04702	A0A3M0KYR6	A0A3M0L160	Uncharacterized protein.	Uncharacterized protein.	0.994
DUI87_04326	DUI87_04756	A0A3M0KYR6	A0A3M0L750	Uncharacterized protein.	ORC4_C domain-containing protein.	0.999
DUI87_04326	DUI87_05659	A0A3M0KYR6	A0A3M0KUW3	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.999
DUI87_04326	DUI87_06544	A0A3M0KYR6	A0A3M0LBQ3	Uncharacterized protein.	Uncharacterized protein.	0.525
DUI87_04326	DUI87_07621	A0A3M0KYR6	A0A3M0KXB2	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.999
DUI87_04326	DUI87_10807	A0A3M0KYR6	A0A3M0KJM0	Uncharacterized protein.	Uncharacterized protein.	0.999
DUI87_04326	DUI87_12466	A0A3M0KYR6	A0A3M0KHM1	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.975
DUI87_04326	DUI87_13167	A0A3M0KYR6	A0A3M0KGJ9	Uncharacterized protein.	AAA_16 domain-containing protein.	0.999
DUI87_04326	DUI87_13263	A0A3M0KYR6	A0A3M0KBC8	Uncharacterized protein.	Mcm10 domain-containing protein.	0.996
DUI87_04326	DUI87_14062	A0A3M0KYR6	A0A3M0KPN2	Uncharacterized protein.	Uncharacterized protein.	0.999
DUI87_04326	DUI87_14744	A0A3M0KYR6	A0A3M0K5N8	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.945
DUI87_04326	DUI87_15109	A0A3M0KYR6	A0A3M0K4S1	Uncharacterized protein.	RING-type domain-containing protein.	0.529
DUI87_04326	DUI87_15291	A0A3M0KYR6	A0A3M0K3R4	Uncharacterized protein.	MCM domain-containing protein; Belongs to the MCM family.	0.998
DUI87_04326	DUI87_16680	A0A3M0KYR6	A0A3M0K7D2	Uncharacterized protein.	AAA domain-containing protein.	0.411
DUI87_04326	DUI87_17587	A0A3M0KYR6	A0A3M0JYF2	Uncharacterized protein.	AAA domain-containing protein.	0.407
DUI87_04326	DUI87_18133	A0A3M0KYR6	A0A3M0K124	Uncharacterized protein.	DBF4-type domain-containing protein.	0.996
DUI87_04326	DUI87_20274	A0A3M0KYR6	A0A3M0JS71	Uncharacterized protein.	DNA helicase; Belongs to the MCM family.	0.999
DUI87_04326	DUI87_21161	A0A3M0KYR6	A0A3M0JM99	Uncharacterized protein.	AAA domain-containing protein.	0.438
DUI87_04326	DUI87_21306	A0A3M0KYR6	A0A3M0JTS3	Uncharacterized protein.	Uncharacterized protein.	0.766