(79 nodes) p53 signaling pathway network (Hirundo rustica)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DUI87_06900	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1382 aa)
	DUI87_35162	Uncharacterized protein. (156 aa)
	DUI87_34619	Uncharacterized protein. (243 aa)
	DUI87_32307	Uncharacterized protein. (532 aa)
	DUI87_32563	Uncharacterized protein. (354 aa)
	DUI87_31620	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (476 aa)
	DUI87_32286	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
	DUI87_32306	Uncharacterized protein. (307 aa)
	DUI87_33753	Uncharacterized protein. (172 aa)
	DUI87_31890	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (648 aa)
	DUI87_31349	Protein kinase domain-containing protein. (767 aa)
	DUI87_33245	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (316 aa)
	DUI87_31990	Uncharacterized protein; Belongs to the peptidase C14A family. (417 aa)
	DUI87_30330	Pyr_redox_2 domain-containing protein. (373 aa)
	DUI87_32345	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (1514 aa)
	DUI87_29246	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (401 aa)
	DUI87_27854	BH4_2 domain-containing protein. (257 aa)
	DUI87_26479	Uncharacterized protein. (156 aa)
	DUI87_25615	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
	DUI87_25243	Fibronectin type-III domain-containing protein. (695 aa)
	DUI87_23978	Uncharacterized protein. (426 aa)
	DUI87_23964	Uncharacterized protein. (426 aa)
	DUI87_22757	Uncharacterized protein. (1057 aa)
	DUI87_23489	Uncharacterized protein. (138 aa)
	DUI87_22841	Uncharacterized protein. (802 aa)
	DUI87_22906	Tetraspanin. (376 aa)
	DUI87_23052	Uncharacterized protein. (1191 aa)
	DUI87_24891	Uncharacterized protein. (178 aa)
	DUI87_28447	Uncharacterized protein. (111 aa)
	DUI87_23942	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (291 aa)
	DUI87_22668	Ribosomal_L7Ae domain-containing protein. (142 aa)
	DUI87_21140	Uncharacterized protein. (238 aa)
	DUI87_22931	WD_REPEATS_REGION domain-containing protein. (463 aa)
	DUI87_21307	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1921 aa)
	DUI87_21015	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (309 aa)
	DUI87_19991	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (285 aa)
	DUI87_18149	Reverse transcriptase domain-containing protein. (1253 aa)
	DUI87_18168	Uncharacterized protein. (260 aa)
	DUI87_17693	IGFBP N-terminal domain-containing protein. (391 aa)
	DUI87_17406	Uncharacterized protein. (634 aa)
	DUI87_18170	Protein kinase domain-containing protein. (135 aa)
	DUI87_18306	Cytochrome c domain-containing protein. (327 aa)
	DUI87_16867	Uncharacterized protein. (295 aa)
	DUI87_14450	Uncharacterized protein. (817 aa)
	DUI87_15057	Ribosomal_L7Ae domain-containing protein. (142 aa)
	DUI87_14049	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (329 aa)
	DUI87_16869	Uncharacterized protein. (523 aa)
	DUI87_20421	Uncharacterized protein. (1120 aa)
	DUI87_16789	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2322 aa)
	DUI87_14525	Uncharacterized protein. (291 aa)
	DUI87_12337	PPM-type phosphatase domain-containing protein. (500 aa)
	DUI87_14075	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (282 aa)
	DUI87_11876	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (309 aa)
	DUI87_11932	Uncharacterized protein. (388 aa)
	DUI87_11681	Uncharacterized protein. (365 aa)
	DUI87_13116	GTSE1_N domain-containing protein; Belongs to the CGI121/TPRKB family. (976 aa)
	DUI87_10364	Uncharacterized protein. (189 aa)
	DUI87_16633	Uncharacterized protein. (524 aa)
	DUI87_10935	Uncharacterized protein. (610 aa)
	DUI87_10940	Uncharacterized protein. (253 aa)
	DUI87_08655	Uncharacterized protein. (250 aa)
	DUI87_10938	GAIN domain-containing protein. (198 aa)
	DUI87_09104	CASPASE_P10 domain-containing protein; Belongs to the peptidase C14A family. (136 aa)
	DUI87_06902	Uncharacterized protein. (282 aa)
	DUI87_10365	Uncharacterized protein. (196 aa)
	DUI87_10665	Uncharacterized protein. (495 aa)
	DUI87_07324	Uncharacterized protein; Belongs to the cyclin family. (364 aa)
	DUI87_07263	Peptidase A2 domain-containing protein. (609 aa)
	DUI87_12767	Uncharacterized protein. (346 aa)
	DUI87_08676	CYCLIN domain-containing protein; Belongs to the cyclin family. (338 aa)
	DUI87_08262	BH4_2 domain-containing protein. (212 aa)
	DUI87_08265	SERPIN domain-containing protein; Belongs to the serpin family. (383 aa)
	DUI87_05854	Uncharacterized protein. (412 aa)
	DUI87_05181	Rap-GAP domain-containing protein. (1764 aa)
	DUI87_04330	Uncharacterized protein; Belongs to the peptidase C14A family. (457 aa)
	DUI87_04659	Uncharacterized protein. (488 aa)
	DUI87_03581	Ribosomal_L7Ae domain-containing protein. (141 aa)
	DUI87_00348	SERPIN domain-containing protein; Belongs to the serpin family. (382 aa)
	DUI87_00283	SERPIN domain-containing protein; Belongs to the serpin family. (334 aa)

Your Current Organism:

Hirundo rustica

NCBI taxonomy Id: 333673
Other names: H. rustica rustica, Hirundo rustica rustica

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DUI87_00283	DUI87_08265	A0A3M0LID8	A0A3M0KT20	SERPIN domain-containing protein; Belongs to the serpin family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.657
DUI87_00283	DUI87_23052	A0A3M0LID8	A0A3M0JHQ1	SERPIN domain-containing protein; Belongs to the serpin family.	Uncharacterized protein.	0.532
DUI87_00348	DUI87_08265	A0A3M0LBK7	A0A3M0KT20	SERPIN domain-containing protein; Belongs to the serpin family.	SERPIN domain-containing protein; Belongs to the serpin family.	0.647
DUI87_00348	DUI87_23052	A0A3M0LBK7	A0A3M0JHQ1	SERPIN domain-containing protein; Belongs to the serpin family.	Uncharacterized protein.	0.532
DUI87_03581	DUI87_08676	A0A3M0L098	A0A3M0KS85	Ribosomal_L7Ae domain-containing protein.	CYCLIN domain-containing protein; Belongs to the cyclin family.	0.649
DUI87_03581	DUI87_11876	A0A3M0L098	A0A3M0KEZ5	Ribosomal_L7Ae domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.972
DUI87_03581	DUI87_15057	A0A3M0L098	A0A3M0K6I0	Ribosomal_L7Ae domain-containing protein.	Ribosomal_L7Ae domain-containing protein.	0.937
DUI87_03581	DUI87_18168	A0A3M0L098	A0A3M0JW52	Ribosomal_L7Ae domain-containing protein.	Uncharacterized protein.	0.777
DUI87_03581	DUI87_18170	A0A3M0L098	A0A3M0K162	Ribosomal_L7Ae domain-containing protein.	Protein kinase domain-containing protein.	0.777
DUI87_03581	DUI87_22668	A0A3M0L098	A0A3M0JL06	Ribosomal_L7Ae domain-containing protein.	Ribosomal_L7Ae domain-containing protein.	0.909
DUI87_03581	DUI87_29246	A0A3M0L098	A0A3M0J0S0	Ribosomal_L7Ae domain-containing protein.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.959
DUI87_03581	DUI87_31349	A0A3M0L098	A0A3M0IUW5	Ribosomal_L7Ae domain-containing protein.	Protein kinase domain-containing protein.	0.777
DUI87_03581	DUI87_31890	A0A3M0L098	A0A3M0IUV8	Ribosomal_L7Ae domain-containing protein.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.707
DUI87_03581	DUI87_33245	A0A3M0L098	A0A3M0IV09	Ribosomal_L7Ae domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.777
DUI87_04330	DUI87_08262	A0A3M0KZ73	A0A3M0KSB3	Uncharacterized protein; Belongs to the peptidase C14A family.	BH4_2 domain-containing protein.	0.880
DUI87_04330	DUI87_09104	A0A3M0KZ73	A0A3M0KL96	Uncharacterized protein; Belongs to the peptidase C14A family.	CASPASE_P10 domain-containing protein; Belongs to the peptidase C14A family.	0.995
DUI87_04330	DUI87_11681	A0A3M0KZ73	A0A3M0KG37	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.988
DUI87_04330	DUI87_11876	A0A3M0KZ73	A0A3M0KEZ5	Uncharacterized protein; Belongs to the peptidase C14A family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.455
DUI87_04330	DUI87_12767	A0A3M0KZ73	A0A3M0KS65	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.503
DUI87_04330	DUI87_16789	A0A3M0KZ73	A0A3M0K8F4	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.824