(23 nodes) Tricarboxylic acid cycle enzyme complex network (Fusarium verticillioides)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	FVEG_04578	GFA domain-containing protein. (176 aa)
	FVEG_02047	2-oxoisovalerate dehydrogenase E1 component, beta subunit. (404 aa)
	FVEG_00241	GFA domain-containing protein. (136 aa)
	FVEG_00018	Uncharacterized protein. (325 aa)
	FVEG_13236	CoA_binding domain-containing protein. (296 aa)
	FVEG_11642	2-oxoglutarate dehydrogenase E2 component (Dihydrolipoamide succinyltransferase). (434 aa)
	FVEG_07484	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (329 aa)
	FVEG_05911	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (378 aa)
	FVEG_08447	D-malate dehydrogenase. (361 aa)
	FVEG_11413	DUF2183 domain-containing protein. (416 aa)
	FVEG_12073	Ligase_CoA domain-containing protein. (295 aa)
	FVEG_12071	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (333 aa)
	FVEG_11816	Uncharacterized protein. (496 aa)
	FVEG_11561	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (447 aa)
	FVEG_11417	Uncharacterized protein. (135 aa)
	FVEG_13237	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (437 aa)
	FVEG_12170	Dihydrolipoyllysine-residue succinyltransferase, E2 component. (430 aa)
	FVEG_17174	Isochorismatase domain-containing protein. (193 aa)
	FVEG_02902	GFA domain-containing protein. (136 aa)
	FVEG_03868	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (449 aa)
	FVEG_03754	Iso_dh domain-containing protein. (369 aa)
	FVEG_01836	Fumarate hydratase, mitochondrial. (529 aa)
	FVEG_04134	Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (381 aa)

Your Current Organism:

Fusarium verticillioides

NCBI taxonomy Id: 334819
Other names: F. verticillioides 7600, Fusarium verticillioides 7600, Gibberella moniliformis 7600

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FVEG_00018	FVEG_04134	W7LK19	W7LUL1	Uncharacterized protein.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.597
FVEG_00018	FVEG_05911	W7LK19	W7MJV7	Uncharacterized protein.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.504
FVEG_00018	FVEG_07484	W7LK19	W7MIE3	Uncharacterized protein.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.588
FVEG_00018	FVEG_11561	W7LK19	W7MZ25	Uncharacterized protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.464
FVEG_00018	FVEG_11642	W7LK19	W7N9J5	Uncharacterized protein.	2-oxoglutarate dehydrogenase E2 component (Dihydrolipoamide succinyltransferase).	0.452
FVEG_00018	FVEG_12071	W7LK19	W7N0K2	Uncharacterized protein.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.534
FVEG_00018	FVEG_12073	W7LK19	W7MQG6	Uncharacterized protein.	Ligase_CoA domain-containing protein.	0.464
FVEG_00018	FVEG_12170	W7LK19	W7MRV1	Uncharacterized protein.	Dihydrolipoyllysine-residue succinyltransferase, E2 component.	0.452
FVEG_00018	FVEG_13236	W7LK19	W7NFZ3	Uncharacterized protein.	CoA_binding domain-containing protein.	0.534
FVEG_00018	FVEG_13237	W7LK19	W7MUK2	Uncharacterized protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.464
FVEG_00018	FVEG_17174	W7LK19	W7MQS7	Uncharacterized protein.	Isochorismatase domain-containing protein.	0.452
FVEG_00241	FVEG_05911	W7LKK2	W7MJV7	GFA domain-containing protein.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.885
FVEG_00241	FVEG_11561	W7LKK2	W7MZ25	GFA domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.435
FVEG_00241	FVEG_11642	W7LKK2	W7N9J5	GFA domain-containing protein.	2-oxoglutarate dehydrogenase E2 component (Dihydrolipoamide succinyltransferase).	0.466
FVEG_00241	FVEG_12073	W7LKK2	W7MQG6	GFA domain-containing protein.	Ligase_CoA domain-containing protein.	0.435
FVEG_00241	FVEG_12170	W7LKK2	W7MRV1	GFA domain-containing protein.	Dihydrolipoyllysine-residue succinyltransferase, E2 component.	0.466
FVEG_00241	FVEG_13237	W7LKK2	W7MUK2	GFA domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.435
FVEG_00241	FVEG_17174	W7LKK2	W7MQS7	GFA domain-containing protein.	Isochorismatase domain-containing protein.	0.466
FVEG_01836	FVEG_04134	W7M173	W7LUL1	Fumarate hydratase, mitochondrial.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.718
FVEG_01836	FVEG_05911	W7M173	W7MJV7	Fumarate hydratase, mitochondrial.	Isocitrate dehydrogenase [NAD] subunit, mitochondrial.	0.664