(56 nodes) Purine nucleoside monophosphate metabolic process, and Purine ribonucleoside metabolic process network (Gambusia affinis)

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	ENSGAFP00000000816	Adenylosuccinate synthase 2. (522 aa)
	CCH79_00001126	dNK domain-containing protein. (263 aa)
	CCH79_00005816	Pribosyltran domain-containing protein. (218 aa)
	NT5C3B	Uncharacterized protein. (303 aa)
	PDE1C	Phosphodiesterase. (576 aa)
	ENSGAFP00000002254	Purine nucleoside phosphorylase 5a. (294 aa)
	CCH79_00018312	Uncharacterized protein. (570 aa)
	CCH79_00000504	Uncharacterized protein. (361 aa)
	NT5M	Uncharacterized protein. (230 aa)
	CCH79_00003659	Uncharacterized protein. (690 aa)
	IMPDH	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (514 aa)
	GMPR	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (381 aa)
	IMPDH-2	Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (626 aa)
	CCH79_00018956	A_deaminase domain-containing protein. (617 aa)
	ADK	Adenosine kinase. (365 aa)
	CCH79_00019340	Uncharacterized protein. (160 aa)
	CCH79_00012330	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (215 aa)
	CCH79_00011820	AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (773 aa)
	ITPA	Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (184 aa)
	CCH79_00000824	Uncharacterized protein. (480 aa)
	CCH79_00001587	PfkB domain-containing protein. (371 aa)
	AK3-2	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (226 aa)
	CCH79_00020729	Metallophos domain-containing protein; Belongs to the 5'-nucleotidase family. (608 aa)
	CCH79_00016640	Guanylate kinase-like domain-containing protein. (734 aa)
	CCH79_00020065	Uncharacterized protein; Belongs to the adenylate kinase family. (457 aa)
	CCH79_00017305	Pribosyltran domain-containing protein. (181 aa)
	GMPR-2	GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa)
	CCH79_00000373	Uncharacterized protein. (1693 aa)
	CCH79_00004460	Uncharacterized protein. (662 aa)
	CCH79_00010793	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (334 aa)
	CCH79_00000962	Uncharacterized protein; Belongs to the adenylate kinase family. (189 aa)
	CCH79_00011330	Phosphodiesterase. (735 aa)
	CCH79_00018683	A_deaminase domain-containing protein. (348 aa)
	CCH79_00010283	Pribosyltran domain-containing protein. (200 aa)
	CCH79_00016994	Phosphodiesterase. (434 aa)
	CCH79_00012740	Uncharacterized protein. (558 aa)
	CCH79_00019848	PNP_UDP_1 domain-containing protein. (277 aa)
	ENSGAFP00000019298	annotation not available (519 aa)
	CCH79_00002123	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (473 aa)
	CCH79_00013901	Uncharacterized protein. (161 aa)
	CCH79_00013014	Uncharacterized protein. (505 aa)
	CCH79_00008183	Phosphodiesterase. (746 aa)
	CCH79_00017885	Uncharacterized protein. (234 aa)
	ENSGAFP00000025098	IMP (inosine 5'-monophosphate) dehydrogenase 1b. (613 aa)
	ADSSL1	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
	CCH79_00015232	A_deaminase_N domain-containing protein. (355 aa)
	CCH79_00004615	Uncharacterized protein. (366 aa)
	CCH79_00009097	dNK domain-containing protein. (320 aa)
	CCH79_00008572	Uncharacterized protein. (387 aa)
	ENSGAFP00000029056	Adenylate kinase 2. (240 aa)
	ENSGAFP00000031113	Adenylate kinase 5. (549 aa)
	CCH79_00009721	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (296 aa)
	ENSGAFP00000032113	Adenosine monophosphate deaminase 2a. (801 aa)
	CCH79_00010103	PNP_UDP_1 domain-containing protein. (297 aa)
	CCH79_00016145	dNK domain-containing protein. (266 aa)
	CCH79_00017147	Phosphodiesterase. (516 aa)

Your Current Organism:

Gambusia affinis

NCBI taxonomy Id: 33528
Other names: G. affinis, western mosquitofish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADK	ADSSL1	ENSGAFP00000008168	ENSGAFP00000025973	Adenosine kinase.	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.798
ADK	AK3-2	ENSGAFP00000008168	ENSGAFP00000012586	Adenosine kinase.	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.941
ADK	CCH79_00000373	ENSGAFP00000008168	ENSGAFP00000016118	Adenosine kinase.	Uncharacterized protein.	0.950
ADK	CCH79_00000504	ENSGAFP00000008168	ENSGAFP00000002397	Adenosine kinase.	Uncharacterized protein.	0.949
ADK	CCH79_00000824	ENSGAFP00000008168	ENSGAFP00000011858	Adenosine kinase.	Uncharacterized protein.	0.882
ADK	CCH79_00000962	ENSGAFP00000008168	ENSGAFP00000016923	Adenosine kinase.	Uncharacterized protein; Belongs to the adenylate kinase family.	0.963
ADK	CCH79_00001126	ENSGAFP00000008168	ENSGAFP00000001432	Adenosine kinase.	dNK domain-containing protein.	0.721
ADK	CCH79_00001587	ENSGAFP00000008168	ENSGAFP00000012156	Adenosine kinase.	PfkB domain-containing protein.	0.905
ADK	CCH79_00002123	ENSGAFP00000008168	ENSGAFP00000019687	Adenosine kinase.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.798
ADK	CCH79_00003659	ENSGAFP00000008168	ENSGAFP00000003771	Adenosine kinase.	Uncharacterized protein.	0.799
ADK	CCH79_00004460	ENSGAFP00000008168	ENSGAFP00000016143	Adenosine kinase.	Uncharacterized protein.	0.941
ADK	CCH79_00004615	ENSGAFP00000008168	ENSGAFP00000026162	Adenosine kinase.	Uncharacterized protein.	0.952
ADK	CCH79_00005816	ENSGAFP00000008168	ENSGAFP00000001616	Adenosine kinase.	Pribosyltran domain-containing protein.	0.564
ADK	CCH79_00008183	ENSGAFP00000008168	ENSGAFP00000023657	Adenosine kinase.	Phosphodiesterase.	0.947
ADK	CCH79_00008572	ENSGAFP00000008168	ENSGAFP00000027896	Adenosine kinase.	Uncharacterized protein.	0.949
ADK	CCH79_00009097	ENSGAFP00000008168	ENSGAFP00000027173	Adenosine kinase.	dNK domain-containing protein.	0.602
ADK	CCH79_00009721	ENSGAFP00000008168	ENSGAFP00000031166	Adenosine kinase.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.965
ADK	CCH79_00010103	ENSGAFP00000008168	ENSGAFP00000032492	Adenosine kinase.	PNP_UDP_1 domain-containing protein.	0.965
ADK	CCH79_00010283	ENSGAFP00000008168	ENSGAFP00000018587	Adenosine kinase.	Pribosyltran domain-containing protein.	0.902
ADK	CCH79_00010793	ENSGAFP00000008168	ENSGAFP00000016745	Adenosine kinase.	5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family.	0.898