(73 nodes) Alanine, aspartate and glutamate metabolism network (Gambusia affinis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSGAFP00000030075	annotation not available (492 aa)
	ENSGAFP00000030074	annotation not available (525 aa)
	CCH79_00006473	G-patch domain-containing protein. (362 aa)
	CCH79_00018870	AAA domain-containing protein; Belongs to the AAA ATPase family. (365 aa)
	CCH79_00002381	Uncharacterized protein. (464 aa)
	CCH79_00000669	Glutamine synthetase. (375 aa)
	CCH79_00012869	Uncharacterized protein. (280 aa)
	CCH79_00016814	Glutamine amidotransferase type-2 domain-containing protein. (562 aa)
	CCH79_00002754	Uncharacterized protein. (593 aa)
	CCH79_00001417	Uncharacterized protein. (310 aa)
	CCH79_00020770	Uncharacterized protein. (513 aa)
	NAALADL2	N-acetylated alpha-linked acidic dipeptidase like 2. (680 aa)
	GOT1	Aspartate aminotransferase. (409 aa)
	CCH79_00012308	G_PROTEIN_RECEP_F1_2 domain-containing protein. (356 aa)
	ENSGAFP00000008254	Aspartoacylase (aminocyclase) 3, tandem duplicate 2. (317 aa)
	CCH79_00001476	Uncharacterized protein. (410 aa)
	CCH79_00012986	Uncharacterized protein. (285 aa)
	CCH79_00015738	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
	ENSGAFP00000029199	Si:dkey-40g16.6. (269 aa)
	CCH79_00018497	RRN7-type domain-containing protein. (493 aa)
	ENSGAFP00000028700	annotation not available (126 aa)
	CCH79_00011199	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (463 aa)
	CCH79_00010623	ATP-grasp domain-containing protein. (438 aa)
	CCH79_00019172	Uncharacterized protein; Belongs to the aldehyde dehydrogenase family. (556 aa)
	ENSGAFP00000027310	Glutamate decarboxylase 2. (252 aa)
	ENSGAFP00000027304	Glutamate decarboxylase 2. (243 aa)
	CCH79_00007928	DAO domain-containing protein. (187 aa)
	ENSGAFP00000027257	Zgc:172341. (154 aa)
	CCH79_00009274	Gln-synt_C domain-containing protein; Belongs to the glutamine synthetase family. (710 aa)
	CCH79_00011133	CN hydrolase domain-containing protein. (286 aa)
	ADSSL1	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
	ENSGAFP00000025967	annotation not available (574 aa)
	CCH79_00011078	Uncharacterized protein. (391 aa)
	CCH79_00009030	Uncharacterized protein. (669 aa)
	CCH79_00011042	Glutamine synthetase. (373 aa)
	CCH79_00013515	Uncharacterized protein. (479 aa)
	ENSGAFP00000000816	Adenylosuccinate synthase 2. (522 aa)
	CCH79_00002699	Uncharacterized protein. (414 aa)
	CCH79_00010451	Aspartate aminotransferase. (428 aa)
	CCH79_00016937	ANK_REP_REGION domain-containing protein. (540 aa)
	ENSGAFP00000021725	annotation not available (475 aa)
	ENSGAFP00000021695	annotation not available (473 aa)
	ENSGAFP00000021505	Glutaminase 2b (liver, mitochondrial). (473 aa)
	CCH79_00017680	ELFV_dehydrog domain-containing protein. (521 aa)
	CCH79_00002152	Uncharacterized protein. (318 aa)
	CCH79_00002123	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (473 aa)
	CCH79_00020749	Amine oxidase. (532 aa)
	CCH79_00006587	ANK_REP_REGION domain-containing protein. (601 aa)
	CCH79_00000992	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (490 aa)
	CCH79_00011361	Uncharacterized protein. (555 aa)
	CCH79_00002906	Uncharacterized protein. (1506 aa)
	CCH79_00000380	MFS domain-containing protein. (577 aa)
	CCH79_00005299	Aminotran_5 domain-containing protein. (429 aa)
	CCH79_00013796	Uncharacterized protein. (153 aa)
	ASS1	Uncharacterized protein. (443 aa)
	CCH79_00013790	ANK_REP_REGION domain-containing protein. (627 aa)
	CCH79_00013673	Uncharacterized protein; Belongs to the complex I LYR family. (1577 aa)
	CCH79_00013667	Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (481 aa)
	CCH79_00006867	Nfu_N domain-containing protein. (254 aa)
	CCH79_00006866	Uncharacterized protein. (682 aa)
	ENSGAFP00000013987	Zgc:110319. (256 aa)
	CCH79_00001642	Aspartate aminotransferase. (410 aa)
	CCH79_00004275	Aminotran_1_2 domain-containing protein. (513 aa)
	CCH79_00003162	ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (570 aa)
	CCH79_00003726	Uncharacterized protein. (739 aa)
	CCH79_00006044	Uncharacterized protein. (685 aa)
	CCH79_00001553	Uncharacterized protein. (311 aa)
	CCH79_00019790	Uncharacterized protein. (333 aa)
	CCH79_00000619	Uncharacterized protein. (969 aa)
	CCH79_00009841	AAA domain-containing protein; Belongs to the AAA ATPase family. (381 aa)
	CCH79_00005435	Aminotran_1_2 domain-containing protein. (516 aa)
	CCH79_00005371	Aminotran_1_2 domain-containing protein. (545 aa)
	ENSGAFP00000031719	Glutamate-ammonia ligase (glutamine synthase) a. (389 aa)

Your Current Organism:

Gambusia affinis

NCBI taxonomy Id: 33528
Other names: G. affinis, western mosquitofish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADSSL1	ASS1	ENSGAFP00000025973	ENSGAFP00000016077	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.948
ADSSL1	CCH79_00000619	ENSGAFP00000025973	ENSGAFP00000009377	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.944
ADSSL1	CCH79_00001417	ENSGAFP00000025973	ENSGAFP00000005197	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.955
ADSSL1	CCH79_00001476	ENSGAFP00000025973	ENSGAFP00000008686	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.540
ADSSL1	CCH79_00001553	ENSGAFP00000025973	ENSGAFP00000011243	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.952
ADSSL1	CCH79_00001642	ENSGAFP00000025973	ENSGAFP00000013842	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Aspartate aminotransferase.	0.927
ADSSL1	CCH79_00002123	ENSGAFP00000025973	ENSGAFP00000019687	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.951
ADSSL1	CCH79_00002381	ENSGAFP00000025973	ENSGAFP00000003348	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.773
ADSSL1	CCH79_00002699	ENSGAFP00000025973	ENSGAFP00000000420	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.728
ADSSL1	CCH79_00002754	ENSGAFP00000025973	ENSGAFP00000004633	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.884
ADSSL1	CCH79_00002906	ENSGAFP00000025973	ENSGAFP00000017197	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.776
ADSSL1	CCH79_00004275	ENSGAFP00000025973	ENSGAFP00000013819	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Aminotran_1_2 domain-containing protein.	0.523
ADSSL1	CCH79_00005371	ENSGAFP00000025973	ENSGAFP00000031799	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Aminotran_1_2 domain-containing protein.	0.523
ADSSL1	CCH79_00005435	ENSGAFP00000025973	ENSGAFP00000031918	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Aminotran_1_2 domain-containing protein.	0.523
ADSSL1	CCH79_00006044	ENSGAFP00000025973	ENSGAFP00000012486	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.724
ADSSL1	CCH79_00006866	ENSGAFP00000025973	ENSGAFP00000014854	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.724
ADSSL1	CCH79_00010451	ENSGAFP00000025973	ENSGAFP00000000440	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Aspartate aminotransferase.	0.966
ADSSL1	CCH79_00011133	ENSGAFP00000025973	ENSGAFP00000026882	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	CN hydrolase domain-containing protein.	0.541
ADSSL1	CCH79_00011199	ENSGAFP00000025973	ENSGAFP00000028699	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Amidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.840
ADSSL1	CCH79_00011361	ENSGAFP00000025973	ENSGAFP00000017641	Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Uncharacterized protein.	0.884