(122 nodes) Mitophagy - animal network (Gambusia affinis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCH79_00007813	Protein kinase domain-containing protein. (1084 aa)
	SRC	SRC proto-oncogene, non-receptor tyrosine kinase. (550 aa)
	CCH79_00016422	Uncharacterized protein. (1405 aa)
	CCH79_00016436	BH4_2 domain-containing protein. (227 aa)
	CCH79_00016792	Uncharacterized protein. (234 aa)
	ENSGAFP00000003292	Forkhead box O6 b. (399 aa)
	ENSGAFP00000003319	annotation not available (205 aa)
	CCH79_00016794	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (354 aa)
	CCH79_00008632	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
	CCH79_00019631	WD_REPEATS_REGION domain-containing protein. (1437 aa)
	CCH79_00003044	APG6 domain-containing protein. (448 aa)
	REL	RHD domain-containing protein. (638 aa)
	CCH79_00000683	Uncharacterized protein. (221 aa)
	CCH79_00014532	RHD domain-containing protein. (629 aa)
	CCH79_00007571	Rab-GAP TBC domain-containing protein. (462 aa)
	CCH79_00017422	Uncharacterized protein. (723 aa)
	CCH79_00012908	Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (154 aa)
	CCH79_00004401	Uncharacterized protein. (702 aa)
	CCH79_00013162	Uncharacterized protein. (197 aa)
	CCH79_00019162	Uncharacterized protein. (649 aa)
	MITF	BHLH domain-containing protein. (515 aa)
	CCH79_00013574	Uncharacterized protein. (187 aa)
	CCH79_00009785	Protein kinase domain-containing protein. (892 aa)
	CCH79_00003684	Arf-GAP domain-containing protein. (593 aa)
	CCH79_00007591	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (408 aa)
	CCH79_00007597	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (217 aa)
	ENSGAFP00000006885	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	ENSGAFP00000007307	Transcription factor EB. (508 aa)
	CCH79_00019865	RBR-type E3 ubiquitin transferase. (171 aa)
	ENSGAFP00000007394	annotation not available (185 aa)
	CSDE1	Uncharacterized protein. (689 aa)
	CCH79_00007620	Uncharacterized protein. (838 aa)
	CCH79_00012961	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (343 aa)
	CCH79_00012966	Uncharacterized protein. (122 aa)
	CCH79_00000756	Protein kinase domain-containing protein. (963 aa)
	CCH79_00004921	USP domain-containing protein; Belongs to the peptidase C19 family. (1076 aa)
	FUNDC1	Uncharacterized protein. (158 aa)
	ENSGAFP00000009397	annotation not available (214 aa)
	CCH79_00009852	Uncharacterized protein. (299 aa)
	ENSGAFP00000009781	Jun proto-oncogene, AP-1 transcription factor subunit. (276 aa)
	NPAS3	Neuronal PAS domain protein 3. (984 aa)
	CCH79_00017762	BZIP domain-containing protein. (388 aa)
	CCH79_00007698	Uncharacterized protein. (306 aa)
	CCH79_00016361	Mitogen-activated protein kinase. (384 aa)
	ENSGAFP00000012094	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4b. (204 aa)
	ENSGAFP00000012246	Casein kinase 2, alpha 4 polypeptide. (390 aa)
	CCH79_00006043	Mitogen-activated protein kinase. (425 aa)
	ENSGAFP00000012944	Melanocyte inducing transcription factor a. (402 aa)
	CCH79_00003163	Uncharacterized protein. (368 aa)
	CCH79_00001612	Mitogen-activated protein kinase. (457 aa)
	CCH79_00012477	Uncharacterized protein. (677 aa)
	ENSGAFP00000014831	Ubiquitin specific peptidase 43a. (1229 aa)
	CCH79_00015778	Uncharacterized protein. (198 aa)
	CCH79_00006897	Uncharacterized protein. (235 aa)
	ENSGAFP00000016072	Transcription factor binding to IGHM enhancer 3b. (441 aa)
	CCH79_00008074	Rab-GAP TBC domain-containing protein. (625 aa)
	CCH79_00011299	BZIP domain-containing protein. (237 aa)
	CCH79_00010791	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	CCH79_00001752	Uncharacterized protein. (191 aa)
	CCH79_00015081	BZIP domain-containing protein. (424 aa)
	CCH79_00003853	PAS domain-containing protein. (303 aa)
	ENSGAFP00000017927	Mitogen-activated protein kinase 10. (384 aa)
	CCH79_00005019	Uncharacterized protein. (309 aa)
	CCH79_00003314	PB1 domain-containing protein. (1070 aa)
	ENSGAFP00000018519	Forkhead box O3b. (664 aa)
	CCH79_00018324	Uncharacterized protein. (863 aa)
	CCH79_00001038	Uncharacterized protein. (183 aa)
	CCH79_00007002	Ubiquitin carboxyl-terminal hydrolase. (506 aa)
	CCH79_00003345	SKICH domain-containing protein. (600 aa)
	CCH79_00006257	Uncharacterized protein. (1078 aa)
	CCH79_00016942	Rab-GAP TBC domain-containing protein. (654 aa)
	ENSGAFP00000019712	Sp1 transcription factor. (457 aa)
	CCH79_00020103	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (421 aa)
	CCH79_00007087	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (756 aa)
	ENSGAFP00000020435	annotation not available (112 aa)
	CCH79_00010899	Uncharacterized protein. (125 aa)
	ENSGAFP00000021072	Ribosomal protein S27a. (156 aa)
	CCH79_00013018	Uncharacterized protein. (574 aa)
	CCH79_00005092	Uncharacterized protein. (211 aa)
	CCH79_00017907	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (758 aa)
	REM1	RRAD and GEM like GTPase 1. (307 aa)
	CCH79_00015586	USP domain-containing protein; Belongs to the peptidase C19 family. (1292 aa)
	CCH79_00016870	Uncharacterized protein. (3527 aa)
	CCH79_00015619	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (618 aa)
	CCH79_00005491	Uncharacterized protein. (97 aa)
	USP15	Uncharacterized protein; Belongs to the peptidase C19 family. (1001 aa)
	CCH79_00014735	USP domain-containing protein; Belongs to the peptidase C19 family. (1067 aa)
	CCH79_00015195	GSAP-16 domain-containing protein. (146 aa)
	CCH79_00015217	BHLH domain-containing protein. (461 aa)
	CCH79_00015234	Uncharacterized protein. (150 aa)
	CCH79_00018968	Uncharacterized protein; Belongs to the peptidase C19 family. (814 aa)
	CCH79_00008421	Uncharacterized protein. (942 aa)
	ENSGAFP00000026636	Ubiquitin specific peptidase 31. (1289 aa)
	CCH79_00017051	Arf-GAP domain-containing protein. (467 aa)
	CCH79_00002975	Uncharacterized protein. (208 aa)
	TOMM7	Translocase of outer mitochondrial membrane 7. (55 aa)
	FOXO3	Fork-head domain-containing protein. (603 aa)
	CCH79_00006360	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (409 aa)
	ENSGAFP00000028039	annotation not available (243 aa)
	CCH79_00020413	Fzo_mitofusin domain-containing protein. (406 aa)
	CCH79_00014580	Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (660 aa)
	CCH79_00011178	Uncharacterized protein. (247 aa)
	CCH79_00004775	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (853 aa)
	CCH79_00018796	Uncharacterized protein; Belongs to the peptidase C19 family. (1580 aa)
	CCH79_00016049	CCHC NOA-type domain-containing protein. (525 aa)
	ENSGAFP00000029540	V-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog. (536 aa)
	CCH79_00006422	Protein kinase domain-containing protein. (575 aa)
	ENSGAFP00000029794	annotation not available (503 aa)
	ENSGAFP00000029814	Si:dkey-13a21.4. (204 aa)
	ENSGAFP00000029824	annotation not available (219 aa)
	CCH79_00017966	E2F_TDP domain-containing protein. (456 aa)
	ENSGAFP00000030390	RAB7a, member RAS oncogene family. (207 aa)
	CCH79_00009706	Uncharacterized protein. (464 aa)
	CCH79_00005403	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (809 aa)
	ENSGAFP00000032048	Si:ch1073-335m2.2. (3140 aa)
	ENSGAFP00000032185	Ubiquitin specific peptidase 4 (proto-oncogene). (1002 aa)
	ENSGAFP00000032211	annotation not available (207 aa)
	KRAS	Uncharacterized protein. (189 aa)
	CCH79_00010032	Uncharacterized protein. (189 aa)
	CSNK2A2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (350 aa)
	ENSGAFP00000032599	GABA(A) receptor-associated protein like 2. (116 aa)
	CCH79_00017131	Uncharacterized protein. (153 aa)

Your Current Organism:

Gambusia affinis

NCBI taxonomy Id: 33528
Other names: G. affinis, western mosquitofish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCH79_00000683	CCH79_00001038	ENSGAFP00000004864	ENSGAFP00000018861	Uncharacterized protein.	Uncharacterized protein.	0.714
CCH79_00000683	CCH79_00001752	ENSGAFP00000004864	ENSGAFP00000017159	Uncharacterized protein.	Uncharacterized protein.	0.804
CCH79_00000683	CCH79_00003314	ENSGAFP00000004864	ENSGAFP00000018379	Uncharacterized protein.	PB1 domain-containing protein.	0.443
CCH79_00000683	CCH79_00005491	ENSGAFP00000004864	ENSGAFP00000024348	Uncharacterized protein.	Uncharacterized protein.	0.466
CCH79_00000683	CCH79_00006422	ENSGAFP00000004864	ENSGAFP00000029603	Uncharacterized protein.	Protein kinase domain-containing protein.	0.487
CCH79_00000683	CCH79_00006897	ENSGAFP00000004864	ENSGAFP00000015795	Uncharacterized protein.	Uncharacterized protein.	0.891
CCH79_00000683	CCH79_00010899	ENSGAFP00000004864	ENSGAFP00000020585	Uncharacterized protein.	Uncharacterized protein.	0.926
CCH79_00000683	CCH79_00012961	ENSGAFP00000004864	ENSGAFP00000008062	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.516
CCH79_00000683	CCH79_00012966	ENSGAFP00000004864	ENSGAFP00000008174	Uncharacterized protein.	Uncharacterized protein.	0.970
CCH79_00000683	CCH79_00016436	ENSGAFP00000004864	ENSGAFP00000002211	Uncharacterized protein.	BH4_2 domain-containing protein.	0.743
CCH79_00000683	CCH79_00017131	ENSGAFP00000004864	ENSGAFP00000032731	Uncharacterized protein.	Uncharacterized protein.	0.479
CCH79_00000683	ENSGAFP00000029824	ENSGAFP00000004864	ENSGAFP00000029824	Uncharacterized protein.	annotation not available	0.743
CCH79_00000683	ENSGAFP00000032599	ENSGAFP00000004864	ENSGAFP00000032599	Uncharacterized protein.	GABA(A) receptor-associated protein like 2.	0.970
CCH79_00000756	CCH79_00003044	ENSGAFP00000009137	ENSGAFP00000004670	Protein kinase domain-containing protein.	APG6 domain-containing protein.	0.992
CCH79_00000756	CCH79_00003314	ENSGAFP00000009137	ENSGAFP00000018379	Protein kinase domain-containing protein.	PB1 domain-containing protein.	0.628
CCH79_00000756	CCH79_00004775	ENSGAFP00000009137	ENSGAFP00000029225	Protein kinase domain-containing protein.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.929
CCH79_00000756	CCH79_00005403	ENSGAFP00000009137	ENSGAFP00000031857	Protein kinase domain-containing protein.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.929
CCH79_00000756	CCH79_00005491	ENSGAFP00000009137	ENSGAFP00000024348	Protein kinase domain-containing protein.	Uncharacterized protein.	0.674
CCH79_00000756	CCH79_00006422	ENSGAFP00000009137	ENSGAFP00000029603	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.446
CCH79_00000756	CCH79_00009785	ENSGAFP00000009137	ENSGAFP00000006620	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.898