STRINGSTRING
Swol_1028 Swol_1028 Swol_1024 Swol_1024 Swol_1020 Swol_1020 Swol_1018 Swol_1018 Swol_1017 Swol_1017 Swol_1012 Swol_1012 miaB miaB nth nth ispG ispG Swol_0800 Swol_0800 Swol_0799 Swol_0799 Swol_0786 Swol_0786 Swol_0785 Swol_0785 Swol_0784 Swol_0784 Swol_0774 Swol_0774 Swol_0698 Swol_0698 Swol_0658 Swol_0658 Swol_0657 Swol_0657 thiC thiC Swol_0427 Swol_0427 Swol_0412 Swol_0412 Swol_0410 Swol_0410 Swol_0408 Swol_0408 Swol_0400 Swol_0400 Swol_0185 Swol_0185 nadA nadA leuC leuC Swol_2293 Swol_2293 Swol_2236 Swol_2236 Swol_2225 Swol_2225 Swol_1828 Swol_1828 hcp hcp leuC-2 leuC-2 Swol_2105 Swol_2105 Swol_1870 Swol_1870 moaA moaA Swol_1835 Swol_1835 Swol_1831 Swol_1831 Swol_1830 Swol_1830 Swol_2473 Swol_2473 Swol_2436 Swol_2436 Swol_1826 Swol_1826 Swol_1825 Swol_1825 purF purF Swol_1703 Swol_1703 Swol_1701 Swol_1701 Swol_1700 Swol_1700 Swol_1674 Swol_1674 Swol_1629 Swol_1629 Swol_1582 Swol_1582 Swol_1574 Swol_1574 Swol_1526 Swol_1526 Swol_1440 Swol_1440 queH queH Swol_1376 Swol_1376 ispH ispH rimO rimO Swol_1245 Swol_1245 rlmN rlmN Swol_1196 Swol_1196 mqnC mqnC mqnE mqnE addB addB Swol_1121 Swol_1121 Swol_1049 Swol_1049 Swol_1040 Swol_1040 Swol_1029 Swol_1029
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
Swol_1028KEGG: dsy:DSY3968 putative formate dehydrogenase alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (536 aa)
Swol_1024NADH dehydrogenase (quinone); KEGG: tte:TTE0893 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit. (407 aa)
Swol_1020KEGG: tte:TTE1073 Biotin synthase and related enzymes. (311 aa)
Swol_1018NADH dehydrogenase (quinone); KEGG: chy:CHY_0732 Fe-hydrogenase, beta subunit. (407 aa)
Swol_1017KEGG: mta:Moth_1717 iron hydrogenase, small subunit. (574 aa)
Swol_1012KEGG: gsu:GSU1624 glycolate oxidase iron-sulfur subunit, putative. (430 aa)
miaBtRNA-i(6)A37 thiotransferase enzyme MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (445 aa)
nthDNA-(apurinic or apyrimidinic site) lyase / endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (207 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (351 aa)
Swol_0800KEGG: chy:CHY_0793 formate dehydrogenase-O, major subunit, selenocysteine-containing. (232 aa)
Swol_0799KEGG: chy:CHY_0793 formate dehydrogenase-O, major subunit, selenocysteine-containing; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (851 aa)
Swol_0786KEGG: sth:STH3295 formate dehydrogenase alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (529 aa)
Swol_0785KEGG: dsy:DSY3969 NADH dehydrogenase I chain G. (353 aa)
Swol_0784NADH dehydrogenase (quinone); KEGG: chy:CHY_0732 Fe-hydrogenase, beta subunit. (408 aa)
Swol_0774KEGG: tte:TTE1468 ELP3 component of the RNA polymerase II complex, consists of an N-terminal BioB/LipA-like domain and a C-terminal histone acetyltransferase domain (only BioB/LipA-like domain in Thermotoga). (362 aa)
Swol_0698Putative iron-sulfur-binding reductase; Oxidoreductase involved in syntrophic growth of S.wolfei with butyrate. Is presumed to link the electron flow from butyryl-CoA dehydrogenases to the membrane, in conjunction with the electron transfer flavoprotein EtfAB. May transfer electrons to the menaquinone pool of the membrane. (714 aa)
Swol_0658KEGG: tko:TK1612 glutamate synthase beta chain-related oxidoreductase, containing 2Fe-2S and 4Fe-4S clusters. (688 aa)
Swol_0657NADH dehydrogenase (quinone); KEGG: tko:TK1613 NADH:ubiquinone oxidoreductase, NADH-binding subunit F. (590 aa)
thiCThiamine biosynthesis protein thiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (424 aa)
Swol_0427KEGG: tde:TDE0392 (R)-2-hydroxyglutaryl-CoA dehydratase, beta subunit, putative. (382 aa)
Swol_0412KEGG: tde:TDE0389 (R)-2-hydroxyglutaryl-CoA dehydratase, beta subunit, putative. (424 aa)
Swol_0410KEGG: gsu:GSU2519 (R)-2-hydroxyglutaryl-CoA dehydratase beta-subunit, putative. (378 aa)
Swol_0408KEGG: dsy:DSY3569 nitrogenase subunit NifH; Belongs to the NifH/BchL/ChlL family. (254 aa)
Swol_0400KEGG: mta:Moth_0814 4Fe-4S ferredoxin, iron-sulfur binding. (300 aa)
Swol_0185KEGG: mta:Moth_0974 histidine kinase. (395 aa)
nadAQuinolinate synthetase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (303 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (416 aa)
Swol_2293KEGG: tte:TTE1955 pyruvate-formate lyase-activating enzyme. (336 aa)
Swol_2236KEGG: sai:Saci_2251 pyruvate synthase delta chain. (85 aa)
Swol_2225KEGG: ctc:CTC02481 tRNA (uracil-5-) -methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (419 aa)
Swol_1828NADH dehydrogenase (quinone); KEGG: chy:CHY_0732 Fe-hydrogenase, beta subunit. (407 aa)
hcpHybrid cluster protein; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O. (526 aa)
leuC-23-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (419 aa)
Swol_2105Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (58 aa)
Swol_1870Uracil-DNA glycosylase-like protein; KEGG: chy:CHY_0179 uracil-DNA glycosylase, family 4. (233 aa)
moaAGTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (326 aa)
Swol_1835KEGG: chy:CHY_1712 aldehyde ferredoxin oxidoreductase, tungsten-containing. (629 aa)
Swol_1831KEGG: dsy:DSY3969 NADH dehydrogenase I chain G. (363 aa)
Swol_1830KEGG: dsy:DSY3968 putative formate dehydrogenase alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (536 aa)
Swol_2473KEGG: chy:CHY_2627 radical SAM domain protein. (458 aa)
Swol_2436KEGG: det:DET0147 [Fe] hydrogenase, large subunit HymC, putative. (563 aa)
Swol_1826KEGG: dsy:DSY3101 formate dehydrogenase alpha subunit. (196 aa)
Swol_1825KEGG: dsy:DSY3101 formate dehydrogenase alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (808 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (475 aa)
Swol_1703KEGG: mta:Moth_0722 aldehyde ferredoxin oxidoreductase. (597 aa)
Swol_1701NADH dehydrogenase (quinone); KEGG: det:DET0729 [Fe] hydrogenase, HymB subunit, putative. (604 aa)
Swol_1700KEGG: sat:SYN_00151 2Fe-2S iron-sulfur cluster domain with dehydrogenase. (247 aa)
Swol_1674KEGG: dsy:DSY3831 hypothetical protein. (343 aa)
Swol_1629KEGG: mag:amb3179 tartrate dehydratase alpha subunit/fumarate hydratase class I, N-terminal domain. (311 aa)
Swol_1582Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (381 aa)
Swol_1574KEGG: chy:CHY_0419 MiaB-like tRNA modifying enzyme. (456 aa)
Swol_1526KEGG: dsy:DSY3492 hypothetical protein. (84 aa)
Swol_1440Ferridoxin; KEGG: sat:SYN_00800 ferridoxin. (140 aa)
queHConserved hypothetical cytosolic protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (186 aa)
Swol_1376Pyruvate ferredoxin oxidoreductase, delta subunit; KEGG: ctc:CTC02527 pyruvate synthase subunit porD. (102 aa)
ispHHydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (687 aa)
rimO2-methylthioadenine synthetase; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (439 aa)
Swol_1245Hypothetical protein. (219 aa)
rlmNConserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (357 aa)
Swol_1196Thiamine pyrophosphate enzyme; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (580 aa)
mqnCConserved hypothetical protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (356 aa)
mqnERadical SAM domain protein; Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. (359 aa)
addBDNA helicase/exodeoxyribonuclease V, subunit B; ATP-dependent DNA helicase; Belongs to the helicase family. AddB/RexB type 1 subfamily. (1124 aa)
Swol_1121KEGG: tte:TTE1204 Lysine 2,3-aminomutase. (422 aa)
Swol_1049Pyruvate formate lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (246 aa)
Swol_1040Signal transduction histidine kinase regulating C4-dicarboxylate transport system-like protein; KEGG: wsu:WS1436 putative two-component sensor. (696 aa)
Swol_1029KEGG: dsy:DSY3969 NADH dehydrogenase I chain G. (358 aa)
Your Current Organism:
Syntrophomonas wolfei Goettingen
NCBI taxonomy Id: 335541
Other names: S. wolfei subsp. wolfei str. Goettingen G311, Syntrophomonas wolfei str. Goettingen, Syntrophomonas wolfei subsp. wolfei Goettingen, Syntrophomonas wolfei subsp. wolfei str. Goettingen, Syntrophomonas wolfei subsp. wolfei str. Goettingen G311, Syntrophomonas wolfei subsp. wolfei str. Gottingen, Syntrophomonas wolfei subsp. wolfei strain Goettingen
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