(25 nodes) DNA integrity checkpoint signaling network (Zymoseptoria tritici IPO323)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	F9X8T4_ZYMTI	Uncharacterized protein. (330 aa)
	MAD2	MAD2-like protein. (230 aa)
	F9WXD5_ZYMTI	Protein kinase domain-containing protein. (144 aa)
	F9WYA6_ZYMTI	Uncharacterized protein. (1022 aa)
	F9X066_ZYMTI	Uncharacterized protein. (696 aa)
	TOR2	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2868 aa)
	F9X2W7_ZYMTI	Uncharacterized protein. (487 aa)
	F9X3P1_ZYMTI	Uncharacterized protein. (1181 aa)
	F9X443_ZYMTI	DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. (464 aa)
	F9X6Y6_ZYMTI	Uncharacterized protein. (128 aa)
	F9X8T5_ZYMTI	Uncharacterized protein. (80 aa)
	CDC7	Protein kinase domain-containing protein. (427 aa)
	F9XF55_ZYMTI	Protein kinase domain-containing protein. (198 aa)
	F9XF56_ZYMTI	Protein kinase domain-containing protein. (168 aa)
	F9XF57_ZYMTI	Protein kinase domain-containing protein. (207 aa)
	F9XG05_ZYMTI	Uncharacterized protein. (670 aa)
	F9XG39_ZYMTI	AAA domain-containing protein. (511 aa)
	F9XHD2_ZYMTI	BRCT domain-containing protein. (1649 aa)
	F9XIN2_ZYMTI	Uncharacterized protein. (1550 aa)
	F9XJB9_ZYMTI	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (757 aa)
	DOT2401	Nucleosomal histone H3-Lys79 methylase. (401 aa)
	F9XLU8_ZYMTI	Checkpoint protein; Belongs to the HUS1 family. (357 aa)
	F9XNN0_ZYMTI	Protein kinase domain-containing protein. (556 aa)
	F9XQP9_ZYMTI	FHA domain-containing protein. (129 aa)
	F9XS64_ZYMTI	Uncharacterized protein. (137 aa)

Your Current Organism:

Zymoseptoria tritici IPO323

NCBI taxonomy Id: 336722
Other names: Mycosphaerella graminicola IPO323, Z. tritici IPO323

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC7	F9WXD5_ZYMTI	F9XDT1	F9WXD5	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.454
CDC7	F9WYA6_ZYMTI	F9XDT1	F9WYA6	Protein kinase domain-containing protein.	Uncharacterized protein.	0.859
CDC7	F9X2W7_ZYMTI	F9XDT1	F9X2W7	Protein kinase domain-containing protein.	Uncharacterized protein.	0.493
CDC7	F9X3P1_ZYMTI	F9XDT1	F9X3P1	Protein kinase domain-containing protein.	Uncharacterized protein.	0.498
CDC7	F9X6Y6_ZYMTI	F9XDT1	F9X6Y6	Protein kinase domain-containing protein.	Uncharacterized protein.	0.410
CDC7	F9XF55_ZYMTI	F9XDT1	F9XF55	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.454
CDC7	F9XF56_ZYMTI	F9XDT1	F9XF56	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.454
CDC7	F9XF57_ZYMTI	F9XDT1	F9XF57	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.454
CDC7	F9XG05_ZYMTI	F9XDT1	F9XG05	Protein kinase domain-containing protein.	Uncharacterized protein.	0.465
CDC7	F9XG39_ZYMTI	F9XDT1	F9XG39	Protein kinase domain-containing protein.	AAA domain-containing protein.	0.767
CDC7	F9XNN0_ZYMTI	F9XDT1	F9XNN0	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.641
CDC7	F9XQP9_ZYMTI	F9XDT1	F9XQP9	Protein kinase domain-containing protein.	FHA domain-containing protein.	0.465
F9WXD5_ZYMTI	CDC7	F9WXD5	F9XDT1	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.454
F9WXD5_ZYMTI	F9XHD2_ZYMTI	F9WXD5	F9XHD2	Protein kinase domain-containing protein.	BRCT domain-containing protein.	0.628
F9WXD5_ZYMTI	F9XNN0_ZYMTI	F9WXD5	F9XNN0	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.410
F9WXD5_ZYMTI	F9XS64_ZYMTI	F9WXD5	F9XS64	Protein kinase domain-containing protein.	Uncharacterized protein.	0.454
F9WXD5_ZYMTI	TOR2	F9WXD5	F9X2W0	Protein kinase domain-containing protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.607
F9WYA6_ZYMTI	CDC7	F9WYA6	F9XDT1	Uncharacterized protein.	Protein kinase domain-containing protein.	0.859
F9WYA6_ZYMTI	F9X066_ZYMTI	F9WYA6	F9X066	Uncharacterized protein.	Uncharacterized protein.	0.680
F9WYA6_ZYMTI	F9X2W7_ZYMTI	F9WYA6	F9X2W7	Uncharacterized protein.	Uncharacterized protein.	0.486