STRINGSTRING
DIRAS2 DIRAS2 RAC1 RAC1 MYO1F MYO1F PKN2 PKN2 RHOB RHOB CDC42EP3 CDC42EP3 WFDC3 WFDC3 LOC105505188 LOC105505188 ACTL7A ACTL7A GPBAR1 GPBAR1 IQGAP2 IQGAP2 ARPC2 ARPC2 ARHGAP10 ARHGAP10 CYFIP2 CYFIP2 ARHGDIA ARHGDIA ARPC3 ARPC3 RHOG RHOG ARHGEF19 ARHGEF19 ENSCANP00000003895 ENSCANP00000003895 LIMK1 LIMK1 LOC105518569 LOC105518569 ZYX ZYX ENSCANP00000004293 ENSCANP00000004293 FEV FEV VASP VASP WAS WAS PREX2 PREX2 PFN3 PFN3 BAIAP2 BAIAP2 ARHGEF16 ARHGEF16 ENSCANP00000005072 ENSCANP00000005072 RHOF RHOF LOC105501165 LOC105501165 ENSCANP00000005438 ENSCANP00000005438 RHOH RHOH WIPF3 WIPF3 DOCK3 DOCK3 ARHGEF11 ARHGEF11 PAK1 PAK1 TIAM2 TIAM2 ARHGDIB ARHGDIB ABR ABR ARHGEF7 ARHGEF7 RHOA RHOA RHOV RHOV NCKIPSD NCKIPSD PLEKHG5 PLEKHG5 PAK4 PAK4 NAA80 NAA80 VAV2 VAV2 RAPGEF1 RAPGEF1 ACTR2 ACTR2 TES TES ENSCANP00000008814 ENSCANP00000008814 ARHGAP26 ARHGAP26 FMNL2 FMNL2 RHOC RHOC ENSCANP00000009347 ENSCANP00000009347 ARHGEF25 ARHGEF25 AKAP13 AKAP13 DOCK11 DOCK11 PFN2 PFN2 ENSCANP00000011047 ENSCANP00000011047 ENSCANP00000011118 ENSCANP00000011118 TIAM1 TIAM1 LIMK2 LIMK2 FNBP1 FNBP1 ARPC5 ARPC5 RHOQ RHOQ NCK2 NCK2 ENAH ENAH PHLPP2 PHLPP2 ENSCANP00000013076 ENSCANP00000013076 IQGAP3 IQGAP3 CHN1 CHN1 C2CD2 C2CD2 WIPF2 WIPF2 SSH2 SSH2 ARPC4 ARPC4 LOC105521593 LOC105521593 WASL WASL DIAPH2 DIAPH2 WDR1 WDR1 ELMO1 ELMO1 RAC2 RAC2 ARHGEF1 ARHGEF1 ROCK1 ROCK1 ELMO3 ELMO3 NCKAP1 NCKAP1 ARHGAP5 ARHGAP5 ARHGAP12 ARHGAP12 PHLPP1 PHLPP1 DOCK9 DOCK9 DOCK5 DOCK5 SSH1 SSH1 PREX1 PREX1 DOCK1 DOCK1 ARHGEF39 ARHGEF39 ENSCANP00000016772 ENSCANP00000016772 ENSCANP00000016972 ENSCANP00000016972 GMFB GMFB NCKAP1L NCKAP1L PFN4 PFN4 ENSCANP00000017857 ENSCANP00000017857 DIAPH1 DIAPH1 TRIP10 TRIP10 ENSCANP00000018854 ENSCANP00000018854 PKN1 PKN1 ENSCANP00000019082 ENSCANP00000019082 DOCK2 DOCK2 FAM170B FAM170B LOC105524240 LOC105524240 WASF1 WASF1 CFL2 CFL2 WASF2 WASF2 IQGAP1 IQGAP1 CYFIP1 CYFIP1 LOC105505661 LOC105505661 MYO9A MYO9A MYO9B MYO9B GNA12 GNA12 EVL EVL GMIP GMIP GIT1 GIT1 DOCK4 DOCK4 ABI3 ABI3 GIT2 GIT2 WIPF1 WIPF1 ABI1 ABI1 FNBP1L FNBP1L ARHGAP15 ARHGAP15 PAK5 PAK5 ENSCANP00000024873 ENSCANP00000024873 ARHGEF3 ARHGEF3 ACTL8 ACTL8 PAK3 PAK3 LOC105521231 LOC105521231 PFN1 PFN1 RHOJ RHOJ BRK1 BRK1 ARHGDIG ARHGDIG ENSCANP00000027709 ENSCANP00000027709 ABI2 ABI2 ENSCANP00000028906 ENSCANP00000028906 FMNL3 FMNL3 RHOU RHOU ARHGEF28 ARHGEF28 RND2 RND2 CD44 CD44 ENSCANP00000030491 ENSCANP00000030491 KALRN KALRN PAK2 PAK2 RASL11A RASL11A RAPH1 RAPH1 INKA1 INKA1 ARHGEF9 ARHGEF9 CAP2 CAP2 LOC105514391 LOC105514391 DSTN DSTN ARHGEF6 ARHGEF6 TRIO TRIO ROCK2 ROCK2 ACTR3B ACTR3B NET1 NET1 NCK1 NCK1 ENSCANP00000033503 ENSCANP00000033503 ARL9 ARL9 SYDE2 SYDE2 RND3 RND3 ARPC5L ARPC5L BNIP2 BNIP2 ENSCANP00000035343 ENSCANP00000035343 DBNL DBNL GNA13 GNA13 ENSCANP00000036972 ENSCANP00000036972 CAP1 CAP1 ARPC1A ARPC1A ARPC1B ARPC1B DOCK10 DOCK10 ACTR3 ACTR3 CDC42 CDC42 ARHGAP1 ARHGAP1 FHDC1 FHDC1 ENSCANP00000038855 ENSCANP00000038855 PAK6 PAK6 ENSCANP00000038913 ENSCANP00000038913 WASF3 WASF3 ARHGEF12 ARHGEF12 PKN3 PKN3 ELMO2 ELMO2 SCRN2 SCRN2 CFL1 CFL1 ENSCANP00000039977 ENSCANP00000039977 ENSCANP00000040288 ENSCANP00000040288 SSH3 SSH3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DIRAS2DIRAS family GTPase 2. (199 aa)
RAC1Uncharacterized protein. (205 aa)
MYO1FMyosin IF; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1103 aa)
PKN2Protein kinase N2. (983 aa)
RHOBRas homolog family member B. (196 aa)
CDC42EP3CDC42 effector protein 3. (254 aa)
WFDC3WAP four-disulfide core domain 3. (231 aa)
LOC105505188Uncharacterized protein. (569 aa)
ACTL7AActin like 7A; Belongs to the actin family. (435 aa)
GPBAR1G protein-coupled bile acid receptor 1. (330 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1479 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (306 aa)
ARHGAP10Rho GTPase activating protein 10. (786 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
ARHGDIARho GDP dissociation inhibitor alpha. (235 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (173 aa)
RHOGUncharacterized protein. (191 aa)
ARHGEF19Rho guanine nucleotide exchange factor 19. (802 aa)
ENSCANP00000003895Glia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (132 aa)
LIMK1LIM domain kinase 1. (677 aa)
LOC105518569Uncharacterized protein. (191 aa)
ZYXUncharacterized protein. (569 aa)
ENSCANP00000004293ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (153 aa)
FEVFEV transcription factor, ETS family member. (175 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
WASWASP actin nucleation promoting factor. (504 aa)
PREX2Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1606 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
BAIAP2BAI1 associated protein 2. (534 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (712 aa)
ENSCANP00000005072Uncharacterized protein. (168 aa)
RHOFRas homolog family member F, filopodia associated. (211 aa)
LOC105501165Uncharacterized protein. (197 aa)
ENSCANP00000005438Profilin; Belongs to the profilin family. (140 aa)
RHOHRas homolog family member H. (191 aa)
WIPF3WAS/WASL interacting protein family member 3. (339 aa)
DOCK3Dedicator of cytokinesis 3; Belongs to the DOCK family. (2012 aa)
ARHGEF11Rho guanine nucleotide exchange factor 11. (1561 aa)
PAK1Non-specific serine/threonine protein kinase. (555 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1725 aa)
ARHGDIBRho GDP dissociation inhibitor beta. (201 aa)
ABRABR activator of RhoGEF and GTPase. (728 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (748 aa)
RHOARas homolog family member A. (193 aa)
RHOVRas homolog family member V. (157 aa)
NCKIPSDNCK interacting protein with SH3 domain. (722 aa)
PLEKHG5Pleckstrin homology and RhoGEF domain containing G5. (1071 aa)
PAK4Non-specific serine/threonine protein kinase. (597 aa)
NAA80N(alpha)-acetyltransferase 80, NatH catalytic subunit. (308 aa)
VAV2Vav guanine nucleotide exchange factor 2. (810 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1095 aa)
ACTR2Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (350 aa)
TESTestin LIM domain protein. (418 aa)
ENSCANP00000008814Uncharacterized protein. (323 aa)
ARHGAP26Rho GTPase activating protein 26. (814 aa)
FMNL2Formin like 2. (1042 aa)
RHOCRas homolog family member C. (193 aa)
ENSCANP00000009347Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (141 aa)
ARHGEF25DH domain-containing protein. (619 aa)
AKAP13A-kinase anchoring protein 13. (2812 aa)
DOCK11Dedicator of cytokinesis 11; Belongs to the DOCK family. (2037 aa)
PFN2Profilin; Belongs to the profilin family. (91 aa)
ENSCANP00000011047ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (97 aa)
ENSCANP00000011118Uncharacterized protein. (176 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
LIMK2LIM domain kinase 2. (643 aa)
FNBP1Formin binding protein 1. (566 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
RHOQUncharacterized protein. (183 aa)
NCK2Cytoplasmic protein. (380 aa)
ENAHENAH actin regulator. (790 aa)
PHLPP2PH domain and leucine rich repeat protein phosphatase 2. (1346 aa)
ENSCANP00000013076Uncharacterized protein. (164 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1632 aa)
CHN1Chimaerin; GTPase-activating protein for p21-rac. (459 aa)
C2CD2C2 calcium dependent domain containing 2. (696 aa)
WIPF2WAS/WASL interacting protein family member 2. (440 aa)
SSH2Slingshot protein phosphatase 2. (1450 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (189 aa)
LOC105521593Uncharacterized protein. (181 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
DIAPH2Diaphanous related formin 2. (1100 aa)
WDR1WD repeat domain 1. (560 aa)
ELMO1Engulfment and cell motility 1. (727 aa)
RAC2Rac family small GTPase 2. (192 aa)
ARHGEF1Rho guanine nucleotide exchange factor 1. (965 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
ELMO3Engulfment and cell motility 3. (775 aa)
NCKAP1NCK associated protein 1. (1111 aa)
ARHGAP5Rho GTPase activating protein 5. (1502 aa)
ARHGAP12Rho GTPase activating protein 12. (848 aa)
PHLPP1PH domain and leucine rich repeat protein phosphatase 1. (1340 aa)
DOCK9Dedicator of cytokinesis 9; Belongs to the DOCK family. (2100 aa)
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1845 aa)
SSH1Slingshot protein phosphatase 1. (1027 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1664 aa)
DOCK1Dedicator of cytokinesis 1; Belongs to the DOCK family. (1870 aa)
ARHGEF39Rho guanine nucleotide exchange factor 39. (335 aa)
ENSCANP00000016772Uncharacterized protein. (67 aa)
ENSCANP00000016972ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (209 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (150 aa)
NCKAP1LNCK associated protein 1 like. (1134 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
ENSCANP00000017857WD_REPEATS_REGION domain-containing protein. (267 aa)
DIAPH1Diaphanous related formin 1. (1236 aa)
TRIP10Thyroid hormone receptor interactor 10. (527 aa)
ENSCANP00000018854Uncharacterized protein; Belongs to the actin family. (349 aa)
PKN1Protein kinase N1. (898 aa)
ENSCANP00000019082Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (349 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1830 aa)
FAM170BFamily with sequence similarity 170 member B. (282 aa)
LOC105524240Uncharacterized protein. (370 aa)
WASF1WASP family member 1. (559 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (166 aa)
WASF2WASP family member 2. (498 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (1639 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1234 aa)
LOC105505661Profilin; Belongs to the profilin family. (188 aa)
MYO9AMyosin IXA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2548 aa)
MYO9BMyosin IXB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2109 aa)
GNA12G protein subunit alpha 12. (310 aa)
EVLEnah/Vasp-like. (472 aa)
GMIPGEM interacting protein. (974 aa)
GIT1GIT ArfGAP 1. (754 aa)
DOCK4Dedicator of cytokinesis 4; Belongs to the DOCK family. (1980 aa)
ABI3ABI family member 3. (366 aa)
GIT2GIT ArfGAP 2. (760 aa)
WIPF1WAS/WASL interacting protein family member 1. (510 aa)
ABI1Abl interactor 1. (508 aa)
FNBP1LFormin binding protein 1 like. (597 aa)
ARHGAP15Rho GTPase activating protein 15. (475 aa)
PAK5Non-specific serine/threonine protein kinase. (719 aa)
ENSCANP00000024873Uncharacterized protein. (210 aa)
ARHGEF3Rho guanine nucleotide exchange factor 3. (558 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
LOC105521231Uncharacterized protein; Belongs to the actin family. (376 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
RHOJRas homolog family member J. (214 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
ARHGDIGRho GDP dissociation inhibitor gamma. (217 aa)
ENSCANP00000027709Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (135 aa)
ABI2Abl interactor 2. (507 aa)
ENSCANP00000028906ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (166 aa)
FMNL3Formin like 3. (1028 aa)
RHOURas homolog family member U. (215 aa)
ARHGEF28Rho guanine nucleotide exchange factor 28. (1731 aa)
RND2Rho family GTPase 2. (227 aa)
CD44CD44 molecule (Indian blood group). (742 aa)
ENSCANP00000030491WH1 domain-containing protein. (137 aa)
KALRNKalirin RhoGEF kinase. (2986 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
RASL11ARAS like family 11 member A. (242 aa)
RAPH1Ras association (RalGDS/AF-6) and pleckstrin homology domains 1. (1226 aa)
INKA1Inka box actin regulator 1. (287 aa)
ARHGEF9Cdc42 guanine nucleotide exchange factor 9. (555 aa)
CAP2Adenylyl cyclase-associated protein; Belongs to the CAP family. (477 aa)
LOC105514391Uncharacterized protein. (190 aa)
DSTNDestrin, actin depolymerizing factor; Belongs to the actin-binding proteins ADF family. (159 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (2689 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
ACTR3BActin related protein 3B; Belongs to the actin family. (423 aa)
NET1Neuroepithelial cell transforming 1. (595 aa)
NCK1Cytoplasmic protein. (377 aa)
ENSCANP00000033503Uncharacterized protein. (422 aa)
ARL9Uncharacterized protein. (183 aa)
SYDE2Synapse defective Rho GTPase homolog 2. (1194 aa)
RND3Rho family GTPase 3. (244 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (159 aa)
BNIP2BCL2 interacting protein 2. (431 aa)
ENSCANP00000035343Uncharacterized protein. (172 aa)
DBNLDrebrin like. (438 aa)
GNA13G protein subunit alpha 13. (282 aa)
ENSCANP00000036972Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (154 aa)
CAP1Adenylyl cyclase-associated protein; Belongs to the CAP family. (475 aa)
ARPC1AActin related protein 2/3 complex subunit 1A. (320 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
DOCK10Dedicator of cytokinesis 10; Belongs to the DOCK family. (2099 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
CDC42Cell division cycle 42. (191 aa)
ARHGAP1Rho GTPase activating protein 1. (439 aa)
FHDC1FH2 domain containing 1. (1141 aa)
ENSCANP00000038855Uncharacterized protein. (211 aa)
PAK6Non-specific serine/threonine protein kinase. (681 aa)
ENSCANP00000038913WD_REPEATS_REGION domain-containing protein. (238 aa)
WASF3WASP family member 3. (502 aa)
ARHGEF12Rho guanine nucleotide exchange factor 12. (1471 aa)
PKN3Protein kinase N3. (881 aa)
ELMO2Engulfment and cell motility 2. (726 aa)
SCRN2Secernin 2. (425 aa)
CFL1ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (166 aa)
ENSCANP00000039977Profilin; Belongs to the profilin family. (188 aa)
ENSCANP00000040288Uncharacterized protein. (160 aa)
SSH3Slingshot protein phosphatase 3. (657 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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