(34 nodes) Mixed, incl. Protein neddylation, and Elongin complex network (Colobus angolensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SENP8	SUMO peptidase family member, NEDD8 specific. (212 aa)
	SPSB1	SplA/ryanodine receptor domain and SOCS box containing 1. (273 aa)
	RBX1	Ring-box 1. (108 aa)
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	LOC105514185	Ubiquitin-like domain-containing protein. (118 aa)
	ENSCANP00000006972	UBIQUITIN_CONJUGAT_2 domain-containing protein. (140 aa)
	ENSCANP00000007584	Ubiquitin-like domain-containing protein. (120 aa)
	ENSCANP00000010034	Uncharacterized protein. (122 aa)
	LOC105519864	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (187 aa)
	SPSB4	SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa)
	DCUN1D1	DCN1-like protein. (244 aa)
	NEDD8	NEDD8 ubiquitin like modifier. (82 aa)
	ELOC	Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (113 aa)
	LRR1	Leucine rich repeat protein 1. (414 aa)
	ENSCANP00000014295	DCN1-like protein. (248 aa)
	CUL5	Cullin 5; Belongs to the cullin family. (780 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (463 aa)
	CAND2	Cullin associated and neddylation dissociated 2 (putative). (1236 aa)
	CUL2	Cullin 2; Belongs to the cullin family. (758 aa)
	CISH	Cytokine inducible SH2 containing protein. (275 aa)
	NAE1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (527 aa)
	VHL	Von Hippel-Lindau tumor suppressor. (213 aa)
	DCUN1D5	DCN1-like protein. (237 aa)
	DCUN1D2	DCN1-like protein. (258 aa)
	DCUN1D3	DCN1-like protein. (304 aa)
	ENSCANP00000026960	UBIQUITIN_CONJUGAT_2 domain-containing protein. (148 aa)
	DCUN1D4	DCN1-like protein. (333 aa)
	UBE2M	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	SOCS7	Suppressor of cytokine signaling 7. (346 aa)
	UBE2F	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (185 aa)
	RNF7	Ring finger protein 7. (113 aa)
	ENSCANP00000034084	DCN1-like protein. (301 aa)
	ENSCANP00000037504	Uncharacterized protein. (122 aa)
	ENSCANP00000038075	Uncharacterized protein; Belongs to the SKP1 family. (107 aa)

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAND2	CISH	ENSCANP00000018556	ENSCANP00000020236	Cullin associated and neddylation dissociated 2 (putative).	Cytokine inducible SH2 containing protein.	0.489
CAND2	CUL2	ENSCANP00000018556	ENSCANP00000018719	Cullin associated and neddylation dissociated 2 (putative).	Cullin 2; Belongs to the cullin family.	0.917
CAND2	CUL5	ENSCANP00000018556	ENSCANP00000015818	Cullin associated and neddylation dissociated 2 (putative).	Cullin 5; Belongs to the cullin family.	0.839
CAND2	DCUN1D1	ENSCANP00000018556	ENSCANP00000012477	Cullin associated and neddylation dissociated 2 (putative).	DCN1-like protein.	0.566
CAND2	DCUN1D2	ENSCANP00000018556	ENSCANP00000024078	Cullin associated and neddylation dissociated 2 (putative).	DCN1-like protein.	0.566
CAND2	DCUN1D3	ENSCANP00000018556	ENSCANP00000025563	Cullin associated and neddylation dissociated 2 (putative).	DCN1-like protein.	0.531
CAND2	DCUN1D4	ENSCANP00000018556	ENSCANP00000029238	Cullin associated and neddylation dissociated 2 (putative).	DCN1-like protein.	0.485
CAND2	DCUN1D5	ENSCANP00000018556	ENSCANP00000022089	Cullin associated and neddylation dissociated 2 (putative).	DCN1-like protein.	0.504
CAND2	ELOC	ENSCANP00000018556	ENSCANP00000013609	Cullin associated and neddylation dissociated 2 (putative).	Skp1_POZ domain-containing protein; Belongs to the SKP1 family.	0.684
CAND2	ENSCANP00000006972	ENSCANP00000018556	ENSCANP00000006972	Cullin associated and neddylation dissociated 2 (putative).	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.521
CAND2	ENSCANP00000007584	ENSCANP00000018556	ENSCANP00000007584	Cullin associated and neddylation dissociated 2 (putative).	Ubiquitin-like domain-containing protein.	0.537
CAND2	ENSCANP00000010034	ENSCANP00000018556	ENSCANP00000010034	Cullin associated and neddylation dissociated 2 (putative).	Uncharacterized protein.	0.537
CAND2	ENSCANP00000014295	ENSCANP00000018556	ENSCANP00000014295	Cullin associated and neddylation dissociated 2 (putative).	DCN1-like protein.	0.566
CAND2	ENSCANP00000026960	ENSCANP00000018556	ENSCANP00000026960	Cullin associated and neddylation dissociated 2 (putative).	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.521
CAND2	ENSCANP00000034084	ENSCANP00000018556	ENSCANP00000034084	Cullin associated and neddylation dissociated 2 (putative).	DCN1-like protein.	0.531
CAND2	ENSCANP00000037504	ENSCANP00000018556	ENSCANP00000037504	Cullin associated and neddylation dissociated 2 (putative).	Uncharacterized protein.	0.537
CAND2	ENSCANP00000038075	ENSCANP00000018556	ENSCANP00000038075	Cullin associated and neddylation dissociated 2 (putative).	Uncharacterized protein; Belongs to the SKP1 family.	0.684
CAND2	LOC105514185	ENSCANP00000018556	ENSCANP00000006722	Cullin associated and neddylation dissociated 2 (putative).	Ubiquitin-like domain-containing protein.	0.537
CAND2	LOC105519864	ENSCANP00000018556	ENSCANP00000010533	Cullin associated and neddylation dissociated 2 (putative).	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.521
CAND2	LRR1	ENSCANP00000018556	ENSCANP00000014020	Cullin associated and neddylation dissociated 2 (putative).	Leucine rich repeat protein 1.	0.485