115 items (Colobus angolensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSCANP00000026116	Uncharacterized protein. (130 aa)
	DIS3L2	DIS3 like 3'-5' exoribonuclease 2; Belongs to the RNR ribonuclease family. (831 aa)
	IGF2BP3	Insulin like growth factor 2 mRNA binding protein 3. (579 aa)
	ENSCANP00000023614	Sm domain-containing protein. (71 aa)
	AICDA	Activation induced cytidine deaminase. (199 aa)
	CSDE1	Uncharacterized protein. (844 aa)
	RBPMS	RNA binding protein, mRNA processing factor. (202 aa)
	NANOS3	Nanos C2HC-type zinc finger 3; Belongs to the nanos family. (191 aa)
	MEX3B	Mex-3 RNA binding family member B. (727 aa)
	C9orf72	C9orf72-SMCR8 complex subunit. (481 aa)
	LSM3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
	SHFL	Shiftless antiviral inhibitor of ribosomal frameshifting. (291 aa)
	AGO3	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
	LOC105500770	Uncharacterized protein. (363 aa)
	PAN3	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (855 aa)
	PSMC3	AAA domain-containing protein; Belongs to the AAA ATPase family. (439 aa)
	LSM3-3	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
	ENSCANP00000005801	Uncharacterized protein. (314 aa)
	CNOT9	CCR4-NOT transcription complex subunit 9. (318 aa)
	PSMA6	Proteasome subunit alpha type. (252 aa)
	SYNE1	Spectrin repeat containing nuclear envelope protein 1. (8767 aa)
	C19orf54	Chromosome 19 open reading frame 54. (351 aa)
	CARHSP1	Calcium regulated heat stable protein 1. (94 aa)
	TRIM5	Uncharacterized protein. (495 aa)
	EDC3	Enhancer of mRNA decapping 3. (508 aa)
	ZC3H12D	Zinc finger CCCH-type containing 12D. (526 aa)
	LSM14A	Uncharacterized protein. (471 aa)
	ENSCANP00000010775	ATPase_AAA_core domain-containing protein. (385 aa)
	YTHDF1	YTH N6-methyladenosine RNA binding protein 1. (561 aa)
	TRIM21	Tripartite motif containing 21. (475 aa)
	EIF4ENIF1	Eukaryotic translation initiation factor 4E nuclear import factor 1. (973 aa)
	KIAA0355	KIAA0355. (937 aa)
	ENSCANP00000012626	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (109 aa)
	LIN28A	Lin-28 homolog A. (209 aa)
	UPF1	UPF1 RNA helicase and ATPase. (1079 aa)
	APOBEC3F	Uncharacterized protein. (373 aa)
	LOC105512634	Uncharacterized protein. (231 aa)
	CAPRIN1	Cell cycle associated protein 1. (717 aa)
	YTHDF3	YTH N6-methyladenosine RNA binding protein 3. (588 aa)
	IGF2BP1	Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
	LOC105514134	Uncharacterized protein. (457 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1134 aa)
	ENSCANP00000017240	Uncharacterized protein. (91 aa)
	NOCT	Endo/exonuclease/phosphatase domain-containing protein. (431 aa)
	APOBEC3D	Uncharacterized protein. (395 aa)
	DCPS	Decapping enzyme, scavenger. (339 aa)
	CPEB1	Cytoplasmic polyadenylation element binding protein 1. (613 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (875 aa)
	LOC105504658	Uncharacterized protein. (571 aa)
	TNRC6B	Trinucleotide repeat containing adaptor 6B. (1832 aa)
	LOC105518935	AAA domain-containing protein; Belongs to the AAA ATPase family. (426 aa)
	ENSCANP00000014256	Uncharacterized protein. (514 aa)
	BTBD1	BTB domain containing 1. (368 aa)
	LOC105527772	CMP/dCMP-type deaminase domain-containing protein. (199 aa)
	DCP2	Decapping mRNA 2. (420 aa)
	LOC105527837	CMP/dCMP-type deaminase domain-containing protein. (326 aa)
	PSMA4	Proteasome subunit alpha type. (261 aa)
	EDC4	Enhancer of mRNA decapping 4. (1398 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (601 aa)
	TNRC6A	Trinucleotide repeat containing adaptor 6A. (1958 aa)
	LSM6	LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (80 aa)
	CNOT1	CCR4-NOT transcription complex subunit 1. (2382 aa)
	HAX1	HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (279 aa)
	TOP1	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (767 aa)
	POLR2G	RNA polymerase II subunit G. (231 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1191 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7. (285 aa)
	CNOT8	CCR4-NOT transcription complex subunit 8. (292 aa)
	POLR2D	RNA polymerase II subunit D. (142 aa)
	LSM4	U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (139 aa)
	LOC105503388	HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (266 aa)
	TNRC6C	Trinucleotide repeat containing adaptor 6C. (1940 aa)
	ELAVL1	ELAV-like protein; Belongs to the RRM elav family. (326 aa)
	AJUBA	Ajuba LIM protein. (538 aa)
	EIF4E2	Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
	PUM1	Pumilio RNA binding family member 1. (1224 aa)
	DDX6	DEAD-box helicase 6; Belongs to the DEAD box helicase family. (434 aa)
	SQSTM1	Sequestosome 1. (440 aa)
	PSMC2	AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
	AGO1	Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
	ENSCANP00000032068	Uncharacterized protein. (186 aa)
	LSM2	U6 snRNA-associated Sm-like protein LSm2; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (95 aa)
	MOV10	Mov10 RISC complex RNA helicase. (1003 aa)
	ENSCANP00000031207	Uncharacterized protein. (457 aa)
	PATL1	PAT1 homolog 1, processing body mRNA decay factor. (770 aa)
	APOBEC3C	Apolipoprotein B mRNA editing enzyme catalytic subunit 3C. (190 aa)
	ENSCANP00000030698	Endo/exonuclease/phosphatase domain-containing protein. (355 aa)
	BTBD2	BTB domain containing 2. (386 aa)
	PSMA2	Proteasome subunit alpha type. (234 aa)
	ENSCANP00000000468	ATPase_AAA_core domain-containing protein. (421 aa)
	DCP1A	Decapping mRNA 1A. (582 aa)
	NBDY	Negative regulator of P-body association. (68 aa)
	LOC105517174	Sm domain-containing protein. (80 aa)
	IGF2BP2	Insulin like growth factor 2 mRNA binding protein 2. (605 aa)
	ZFP36	ZFP36 ring finger protein. (332 aa)
	LOC105516879	Proteasome endopeptidase complex. (214 aa)
	NANOS2	Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
	MEX3A	Mex-3 RNA binding family member A. (474 aa)
	PATL2	PAT1 homolog 2. (538 aa)
	CNOT3	CCR4-NOT transcription complex subunit 3. (751 aa)
	LOC105523217	Uncharacterized protein. (458 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (587 aa)
	SAMD4B	Sterile alpha motif domain containing 4B. (694 aa)
	AGO4	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (855 aa)
	LSM3-2	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (87 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1187 aa)
	LSM3-4	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (102 aa)
	CNOT2	CCR4-NOT transcription complex subunit 2. (540 aa)
	XRN1	5'-3' exoribonuclease 1. (1706 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
	LIMD1	LIM domains containing 1. (677 aa)
	TRIM71	Tripartite motif containing 71. (654 aa)
	ENSCANP00000026188	AAA domain-containing protein; Belongs to the AAA ATPase family. (430 aa)

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO1	AGO2	ENSCANP00000032455	ENSCANP00000015251	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.981
AGO1	AGO3	ENSCANP00000032455	ENSCANP00000019769	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.857
AGO1	AGO4	ENSCANP00000032455	ENSCANP00000004887	Argonaute RISC component 1; Belongs to the argonaute family.	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.795
AGO1	DCP1A	ENSCANP00000032455	ENSCANP00000000541	Argonaute RISC component 1; Belongs to the argonaute family.	Decapping mRNA 1A.	0.471
AGO1	DCP2	ENSCANP00000032455	ENSCANP00000013677	Argonaute RISC component 1; Belongs to the argonaute family.	Decapping mRNA 2.	0.622
AGO1	DDX6	ENSCANP00000032455	ENSCANP00000037964	Argonaute RISC component 1; Belongs to the argonaute family.	DEAD-box helicase 6; Belongs to the DEAD box helicase family.	0.878
AGO1	EDC3	ENSCANP00000032455	ENSCANP00000010597	Argonaute RISC component 1; Belongs to the argonaute family.	Enhancer of mRNA decapping 3.	0.401
AGO1	LIMD1	ENSCANP00000032455	ENSCANP00000027852	Argonaute RISC component 1; Belongs to the argonaute family.	LIM domains containing 1.	0.401
AGO1	MEX3B	ENSCANP00000032455	ENSCANP00000022153	Argonaute RISC component 1; Belongs to the argonaute family.	Mex-3 RNA binding family member B.	0.438
AGO1	MOV10	ENSCANP00000032455	ENSCANP00000031445	Argonaute RISC component 1; Belongs to the argonaute family.	Mov10 RISC complex RNA helicase.	0.687
AGO1	POLR2D	ENSCANP00000032455	ENSCANP00000039979	Argonaute RISC component 1; Belongs to the argonaute family.	RNA polymerase II subunit D.	0.405
AGO1	TNRC6A	ENSCANP00000032455	ENSCANP00000035722	Argonaute RISC component 1; Belongs to the argonaute family.	Trinucleotide repeat containing adaptor 6A.	0.620
AGO1	TNRC6B	ENSCANP00000032455	ENSCANP00000014817	Argonaute RISC component 1; Belongs to the argonaute family.	Trinucleotide repeat containing adaptor 6B.	0.913
AGO1	TNRC6C	ENSCANP00000032455	ENSCANP00000036164	Argonaute RISC component 1; Belongs to the argonaute family.	Trinucleotide repeat containing adaptor 6C.	0.431
AGO1	UPF1	ENSCANP00000032455	ENSCANP00000013001	Argonaute RISC component 1; Belongs to the argonaute family.	UPF1 RNA helicase and ATPase.	0.424
AGO1	XRN1	ENSCANP00000032455	ENSCANP00000028346	Argonaute RISC component 1; Belongs to the argonaute family.	5'-3' exoribonuclease 1.	0.446
AGO2	AGO1	ENSCANP00000015251	ENSCANP00000032455	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Argonaute RISC component 1; Belongs to the argonaute family.	0.981
AGO2	AGO3	ENSCANP00000015251	ENSCANP00000019769	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.972
AGO2	AGO4	ENSCANP00000015251	ENSCANP00000004887	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs.	0.938
AGO2	CNOT1	ENSCANP00000015251	ENSCANP00000034710	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	CCR4-NOT transcription complex subunit 1.	0.540