STRINGSTRING
GZF1 GZF1 WNT6 WNT6 SLIT2 SLIT2 FGFR2 FGFR2 SMAD1 SMAD1 LZTS2 LZTS2 EYA1 EYA1 RARA RARA PAX2 PAX2 SMAD5 SMAD5 GLI3 GLI3 KIF26B KIF26B HS2ST1 HS2ST1 BMPER BMPER BMP4 BMP4 FOXJ1 FOXJ1 BMP2 BMP2 LAMA5 LAMA5 WNT11 WNT11 CTNNB1 CTNNB1 PTCH1 PTCH1 PBX1 PBX1 ADAMTS16 ADAMTS16 TMEM59L TMEM59L DSPP DSPP WNT1 WNT1 FGF8 FGF8 TGFB1 TGFB1 RET RET DCHS1 DCHS1 FMN1 FMN1 GREB1L GREB1L SDC1 SDC1 HOXA11 HOXA11 SMAD7 SMAD7 SIM1 SIM1 TACSTD2 TACSTD2 BCL2 BCL2 NOG NOG GDF11 GDF11 TCF21 TCF21 FGF1 FGF1 WNT9B WNT9B PKD2 PKD2 SPRY1 SPRY1 SMAD3 SMAD3 SFRP1 SFRP1 CITED1 CITED1 HS3ST3B1 HS3ST3B1 GREB1 GREB1 BMP7 BMP7 GATA3 GATA3 ROBO2 ROBO2 HS3ST3A1 HS3ST3A1 PGF PGF CER1 CER1 SALL1 SALL1 WNT4 WNT4 RARB RARB CRLF1 CRLF1 WT1 WT1 CTNNBIP1 CTNNBIP1 SMAD4 SMAD4 ENSCANP00000030255 ENSCANP00000030255 SHH SHH GDNF GDNF SDC4 SDC4 EPCAM EPCAM ENSCANP00000033948 ENSCANP00000033948 FGF2 FGF2 CALB1 CALB1 DLG1 DLG1 SIX1 SIX1 SMAD2 SMAD2 ARG2 ARG2 ENSCANP00000038657 ENSCANP00000038657 OSR1 OSR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GZF1GDNF inducible zinc finger protein 1. (711 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
RARARetinoic acid receptor alpha. (478 aa)
PAX2Paired box 2. (388 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
GLI3GLI family zinc finger 3. (1580 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2023 aa)
HS2ST1Heparan sulfate 2-O-sulfotransferase 1. (356 aa)
BMPERBMP binding endothelial regulator. (685 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
FOXJ1Forkhead box J1. (389 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
LAMA5Laminin subunit alpha 5. (3457 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
CTNNB1Catenin beta 1. (781 aa)
PTCH1Patched 1. (1449 aa)
PBX1PBX homeobox 1. (430 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1200 aa)
TMEM59LTransmembrane protein 59 like. (286 aa)
DSPPDentin sialophosphoprotein. (1113 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1089 aa)
DCHS1Dachsous cadherin-related 1. (3302 aa)
FMN1Formin 1. (1415 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1924 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (288 aa)
HOXA11Homeobox A11. (312 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
SIM1SIM bHLH transcription factor 1. (766 aa)
TACSTD2Tumor associated calcium signal transducer 2. (325 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
GDF11Growth differentiation factor 11. (345 aa)
TCF21Transcription factor 21. (179 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (780 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (391 aa)
GREB1Growth regulating estrogen receptor binding 1. (1949 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
GATA3GATA binding protein 3. (444 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (235 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (200 aa)
CER1Cerberus 1, DAN family BMP antagonist. (267 aa)
SALL1Spalt like transcription factor 1. (1318 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
RARBRetinoic acid receptor beta. (448 aa)
CRLF1Cytokine receptor like factor 1. (377 aa)
WT1WT1 transcription factor. (517 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ENSCANP00000030255Fork-head domain-containing protein. (189 aa)
SHHSonic hedgehog signaling molecule. (390 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (198 aa)
EPCAMEpithelial cell adhesion molecule. (302 aa)
ENSCANP00000033948Homeobox domain-containing protein. (141 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
CALB1Calbindin 1. (261 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
SIX1SIX homeobox 1. (284 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ARG2Arginase. (354 aa)
ENSCANP00000038657Fork-head domain-containing protein. (200 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.