STRINGSTRING
NEUROD1 NEUROD1 RFX3 RFX3 MEN1 MEN1 NKX6-1 NKX6-1 GDF11 GDF11 FOXA1 FOXA1 LHX3 LHX3 GATA6 GATA6 SMO SMO RBM4B RBM4B KLF4 KLF4 CLCN2 CLCN2 BMP5 BMP5 PDX1 PDX1 CAV1 CAV1 FGF8 FGF8 SPDEF SPDEF BMP6 BMP6 HOXA5 HOXA5 SIDT2 SIDT2 ENSCANP00000010884 ENSCANP00000010884 HNF4A HNF4A CTNNB1 CTNNB1 BMP2 BMP2 BMP4 BMP4 WDR77 WDR77 SLC9A4 SLC9A4 YAP1 YAP1 RARA RARA FGFR2 FGFR2 NR5A2 NR5A2 PDPK1 PDPK1 EXT1 EXT1 NKX2-2 NKX2-2 ASCL1 ASCL1 DLL1 DLL1 WNT4 WNT4 NOTCH1 NOTCH1 RARB RARB PAX6 PAX6 HIF1A HIF1A FZD5 FZD5 BHLHA15 BHLHA15 CDH2 CDH2 GATA2 GATA2 PROX1 PROX1 RFX6 RFX6 AGR2 AGR2 WNT5A WNT5A NFIB NFIB CDK6 CDK6 NKX6-3 NKX6-3 TP63 TP63 PAX4 PAX4 IL31RA IL31RA RARG RARG FASN FASN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NEUROD1Neurogenic differentiation factor. (356 aa)
RFX3Regulatory factor X3. (777 aa)
MEN1Menin 1. (610 aa)
NKX6-1NK6 homeobox 1. (366 aa)
GDF11Growth differentiation factor 11. (345 aa)
FOXA1Forkhead box A1. (447 aa)
LHX3LIM homeobox 3. (332 aa)
GATA6GATA binding protein 6. (462 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (768 aa)
RBM4BRNA binding motif protein 4B. (359 aa)
KLF4Kruppel like factor 4. (479 aa)
CLCN2Chloride channel protein. (898 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (179 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
BMP6Bone morphogenetic protein 6. (331 aa)
HOXA5Homeobox A5. (270 aa)
SIDT2SID1 transmembrane family member 2. (855 aa)
ENSCANP00000010884Uncharacterized protein. (338 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (464 aa)
CTNNB1Catenin beta 1. (781 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
WDR77WD repeat domain 77. (342 aa)
SLC9A4Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (798 aa)
YAP1Yes associated protein 1. (479 aa)
RARARetinoic acid receptor alpha. (478 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (541 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (406 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
NKX2-2NK2 homeobox 2. (273 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (231 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
NOTCH1Notch receptor 1. (2559 aa)
RARBRetinoic acid receptor beta. (448 aa)
PAX6Paired box 6. (478 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (827 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (585 aa)
BHLHA15Basic helix-loop-helix family member a15. (194 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (890 aa)
GATA2GATA binding protein 2. (480 aa)
PROX1Prospero homeobox 1. (737 aa)
RFX6Regulatory factor X6. (928 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (188 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
NKX6-3Homeobox domain-containing protein. (265 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (654 aa)
PAX4Paired box 4. (351 aa)
IL31RAInterleukin 31 receptor A. (750 aa)
RARGRetinoic acid receptor gamma. (461 aa)
FASNFatty acid synthase. (2510 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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