STRINGSTRING
IFI16 IFI16 IFNG IFNG ENSCANP00000015049 ENSCANP00000015049 MITF MITF THOC5 THOC5 TNFRSF11A TNFRSF11A RUNX1 RUNX1 CSF1R CSF1R CCL19 CCL19 SH3PXD2A SH3PXD2A TRAF6 TRAF6 LRRK1 LRRK1 FAM20C FAM20C ITGB8 ITGB8 SFRP1 SFRP1 LEF1 LEF1 EFNA2 EFNA2 BAP1 BAP1 FOS FOS NKX2-3 NKX2-3 CITED2 CITED2 ANXA2 ANXA2 DHRS7B DHRS7B KITLG KITLG PIK3R1 PIK3R1 TCTA TCTA SP3 SP3 IL4 IL4 IRF4 IRF4 GATA3 GATA3 ENSCANP00000023654 ENSCANP00000023654 NRROS NRROS PSEN1 PSEN1 PDE1B PDE1B SBNO2 SBNO2 SNX10 SNX10 GATA2 GATA2 DHRS2 DHRS2 CSF3 CSF3 TSPAN2 TSPAN2 ENSCANP00000031335 ENSCANP00000031335 JUN JUN APP APP JAGN1 JAGN1 CEBPE CEBPE MMP9 MMP9 GAB3 GAB3 EPHA2 EPHA2 BATF3 BATF3 PARP1 PARP1 ZBTB46 ZBTB46 CD109 CD109 CCN4 CCN4 KIT KIT ENSCANP00000036326 ENSCANP00000036326 IL15 IL15 PIK3CD PIK3CD BATF2 BATF2 CD4 CD4 LTBR LTBR IL31RA IL31RA IL25 IL25 FASN FASN IAPP IAPP MAPK14 MAPK14 TCIRG1 TCIRG1 SRC SRC CAMK4 CAMK4 MED1 MED1 JUNB JUNB IL20 IL20 PIR PIR LIF LIF PDE2A PDE2A AP3B1 AP3B1 TREM2 TREM2 TAL1 TAL1 CCR7 CCR7 TGFBR2 TGFBR2 GPR183 GPR183 FARP2 FARP2 GPR68 GPR68 UBD UBD MYH9 MYH9 SIRT1 SIRT1 L3MBTL3 L3MBTL3 TFRC TFRC NOTCH2 NOTCH2 TGFB1 TGFB1 FOXP1 FOXP1 ENSCANP00000009344 ENSCANP00000009344 OCSTAMP OCSTAMP TF TF ENSCANP00000009431 ENSCANP00000009431 GATA1 GATA1 ITGB6 ITGB6 SRP54 SRP54 LBR LBR CTNNB1 CTNNB1 CALCR CALCR RELB RELB IREB2 IREB2 CSF2 CSF2 CD81 CD81 CASP8 CASP8 ENSCANP00000012498 ENSCANP00000012498 CSF1 CSF1 LOC105511316 LOC105511316 CREB1 CREB1 CBFA2T3 CBFA2T3 IL17C IL17C BMP4 BMP4 ATP6AP1 ATP6AP1 DCSTAMP DCSTAMP TNFSF11 TNFSF11 BATF BATF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFI16Interferon gamma inducible protein 16. (729 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
ENSCANP00000015049Uncharacterized protein. (278 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
THOC5THO complex 5. (663 aa)
TNFRSF11ATNF receptor superfamily member 11a. (712 aa)
RUNX1Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (455 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa)
CCL19C-C motif chemokine. (104 aa)
SH3PXD2ASH3 and PX domains 2A. (1133 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
LRRK1Leucine rich repeat kinase 1. (2015 aa)
FAM20CFAM20C golgi associated secretory pathway kinase. (365 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (769 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (227 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (729 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
NKX2-3NK2 homeobox 3. (240 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
ANXA2Annexin. (357 aa)
DHRS7BDehydrogenase/reductase 7B; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (325 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TCTAT-cell leukemia translocation-altered gene protein homolog; May be required for cellular fusion during osteoclastogenesis; Belongs to the TCTA family. (106 aa)
SP3Sp3 transcription factor. (714 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
IRF4Interferon regulatory factor 4. (450 aa)
GATA3GATA binding protein 3. (444 aa)
ENSCANP00000023654Uncharacterized protein. (281 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
PDE1BPhosphodiesterase. (536 aa)
SBNO2Strawberry notch homolog 2. (1210 aa)
SNX10Sorting nexin 10. (201 aa)
GATA2GATA binding protein 2. (480 aa)
DHRS2Dehydrogenase/reductase 2. (280 aa)
CSF3Colony stimulating factor 3. (207 aa)
TSPAN2Tetraspanin. (243 aa)
ENSCANP00000031335Uncharacterized protein. (325 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
APPAmyloid beta precursor protein. (770 aa)
JAGN1Jagunal homolog 1. (183 aa)
CEBPECCAAT/enhancer-binding protein. (281 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
GAB3GRB2 associated binding protein 3. (563 aa)
EPHA2EPH receptor A2. (976 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (131 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
ZBTB46Zinc finger and BTB domain containing 46. (589 aa)
CD109CD109 molecule. (1428 aa)
CCN4Cellular communication network factor 4. (367 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
ENSCANP00000036326Uncharacterized protein. (144 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (162 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
BATF2Basic leucine zipper ATF-like transcription factor 2. (273 aa)
CD4CD4 molecule. (458 aa)
LTBRLymphotoxin beta receptor. (435 aa)
IL31RAInterleukin 31 receptor A. (750 aa)
IL25Interleukin 25. (177 aa)
FASNFatty acid synthase. (2510 aa)
IAPPIslet amyloid polypeptide. (86 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
SRCTyrosine-protein kinase. (458 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (448 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1576 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
IL20Interleukin 20. (176 aa)
PIRPirin; Belongs to the pirin family. (290 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
PDE2APhosphodiesterase. (936 aa)
AP3B1AP-3 complex subunit beta; Belongs to the adaptor complexes large subunit family. (1045 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (242 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (378 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (359 aa)
FARP2FERM, ARH/RhoGEF and pleckstrin domain protein 2. (1055 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (375 aa)
UBDUbiquitin D. (164 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1960 aa)
SIRT1Sirtuin 1. (600 aa)
L3MBTL3L3MBTL histone methyl-lysine binding protein 3. (780 aa)
TFRCTransferrin receptor. (710 aa)
NOTCH2Notch receptor 2. (2471 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
FOXP1Forkhead box P1. (693 aa)
ENSCANP00000009344Uncharacterized protein. (627 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (555 aa)
TFTransferrin; Belongs to the transferrin family. (698 aa)
ENSCANP00000009431Uncharacterized protein. (233 aa)
GATA1GATA binding protein 1. (413 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (746 aa)
SRP54Signal recognition particle 54 kDa protein; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein). Belongs to the GTP-binding SRP family. SRP54 subfamily. (515 aa)
LBRLamin B receptor. (523 aa)
CTNNB1Catenin beta 1. (781 aa)
CALCRCalcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (492 aa)
RELBRELB proto-oncogene, NF-kB subunit. (467 aa)
IREB2Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (964 aa)
CSF2Colony stimulating factor 2. (144 aa)
CD81Tetraspanin. (274 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
ENSCANP00000012498Ig-like domain-containing protein. (212 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (551 aa)
LOC105511316AIG1-type G domain-containing protein. (307 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (586 aa)
IL17CInterleukin 17C. (197 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (468 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (317 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
Server load: low (20%) [HD]