STRINGSTRING
NRP1 NRP1 ISL1 ISL1 ENG ENG PARVA PARVA ENSCANP00000003738 ENSCANP00000003738 TGFBR2 TGFBR2 TBX2 TBX2 GATA6 GATA6 NKX2-5 NKX2-5 FGF8 FGF8 BMPR1A BMPR1A BMP4 BMP4 ROBO1 ROBO1 FGFR2 FGFR2 ZFPM2 ZFPM2 SEMA3C SEMA3C TGFB2 TGFB2 ROBO2 ROBO2 SMAD4 SMAD4 BMPR2 BMPR2 NRP2 NRP2 LRP2 LRP2 TBX20 TBX20
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ENGEndoglin. (658 aa)
PARVAParvin alpha. (411 aa)
ENSCANP00000003738Uncharacterized protein. (247 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
TBX2T-box transcription factor 2. (590 aa)
GATA6GATA binding protein 6. (462 aa)
NKX2-5NK2 homeobox 5. (324 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ROBO1Roundabout guidance receptor 1. (1598 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1137 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (750 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMPR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1030 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
LRP2LDL receptor related protein 2. (4655 aa)
TBX20T-box transcription factor 20. (447 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.