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WNT5A WNT5A NRP2 NRP2 LRP2 LRP2 TBX20 TBX20 DHRS3 DHRS3 NRP1 NRP1 ENSCANP00000035495 ENSCANP00000035495 SOX17 SOX17 ENSCANP00000036326 ENSCANP00000036326 ISL1 ISL1 ENSCANP00000038657 ENSCANP00000038657 PLXND1 PLXND1 SOX11 SOX11 ROBO2 ROBO2 EDNRA EDNRA HEY2 HEY2 TGFB2 TGFB2 SEMA3C SEMA3C CITED2 CITED2 SEC24B SEC24B ZFPM2 ZFPM2 FGFR2 FGFR2 NIPBL NIPBL ROBO1 ROBO1 SFRP2 SFRP2 EYA1 EYA1 TGFBR3 TGFBR3 PITX2 PITX2 TBX3 TBX3 BMP4 BMP4 BMPR1A BMPR1A FOXH1 FOXH1 WNT11 WNT11 NPY1R NPY1R FGF8 FGF8 NKX2-5 NKX2-5 MEF2C MEF2C GATA6 GATA6 TBX2 TBX2 ATF2 ATF2 NPY2R NPY2R TGFBR2 TGFBR2 NOG NOG ENSCANP00000003738 ENSCANP00000003738 NPY5R NPY5R PARVA PARVA FOLR1 FOLR1 ENG ENG GJA5 GJA5 EDN1 EDN1 RYR1 RYR1 JAG1 JAG1 HAND2 HAND2 FZD2 FZD2 NOTCH1 NOTCH1 DVL2 DVL2 HIF1A HIF1A SMAD4 SMAD4 ENSCANP00000030255 ENSCANP00000030255 CRKL CRKL JUN JUN BMPR2 BMPR2 HEYL HEYL ELN ELN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
LRP2LDL receptor related protein 2. (4655 aa)
TBX20T-box transcription factor 20. (447 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ENSCANP00000035495G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (375 aa)
SOX17SRY-box transcription factor 17. (412 aa)
ENSCANP00000036326Uncharacterized protein. (144 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ENSCANP00000038657Fork-head domain-containing protein. (200 aa)
PLXND1Plexin D1. (1736 aa)
SOX11Transcription factor SOX. (372 aa)
ROBO2Roundabout guidance receptor 2. (1439 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (750 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1250 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1137 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
NIPBLNipped-B protein. (2804 aa)
ROBO1Roundabout guidance receptor 1. (1598 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
PITX2Homeobox protein. (325 aa)
TBX3T-box transcription factor 3. (743 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FOXH1Forkhead box H1. (366 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
NPY1RNeuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (383 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
NKX2-5NK2 homeobox 5. (324 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
GATA6GATA binding protein 6. (462 aa)
TBX2T-box transcription factor 2. (590 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
NPY2RNeuropeptide Y receptor Y2; Belongs to the G-protein coupled receptor 1 family. (381 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ENSCANP00000003738Uncharacterized protein. (247 aa)
NPY5RNeuropeptide Y receptor Y5. (445 aa)
PARVAParvin alpha. (411 aa)
FOLR1Folate receptor alpha. (257 aa)
ENGEndoglin. (658 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
EDN1Endothelin 1. (211 aa)
RYR1Ryanodine receptor 1. (4758 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1089 aa)
HAND2Uncharacterized protein. (66 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (543 aa)
NOTCH1Notch receptor 1. (2559 aa)
DVL2Dishevelled segment polarity protein 2. (736 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (827 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ENSCANP00000030255Fork-head domain-containing protein. (189 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
BMPR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1030 aa)
HEYLHes related family bHLH transcription factor with YRPW motif like. (328 aa)
ELNElastin. (703 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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