STRINGSTRING
SPEM2 SPEM2 CLCF1 CLCF1 INHBC INHBC IL11 IL11 BMP1 BMP1 AREG AREG FGF18 FGF18 IL6 IL6 NRG3 NRG3 CSPG5 CSPG5 FGF3 FGF3 BTC BTC FAM71F2 FAM71F2 EPGN EPGN CXCL12 CXCL12 VEGFB VEGFB IL12A IL12A OSGIN1 OSGIN1 MANF MANF RABEP2 RABEP2 THBS4 THBS4 IL9 IL9 NODAL NODAL PDGFC PDGFC FGF2 FGF2 LOC105516700 LOC105516700 HGF HGF GDNF GDNF IL5 IL5 TDGF1 TDGF1 GRN GRN FGF14 FGF14 TGFB3 TGFB3 GDF3 GDF3 RABEP1 RABEP1 LOC105515982-2 LOC105515982-2 BMP8B BMP8B MACC1 MACC1 GMFG GMFG FGF7 FGF7 ENSCANP00000030604 ENSCANP00000030604 INHA INHA LOC105519388 LOC105519388 ENSCANP00000030238 ENSCANP00000030238 CSF3 CSF3 INHBE INHBE PTN PTN VEGFA VEGFA GFER GFER BMP10 BMP10 CCN3 CCN3 ENSCANP00000029034 ENSCANP00000029034 ARTN ARTN GDF1 GDF1 LOC105516701 LOC105516701 NRG1 NRG1 GKN1 GKN1 JAG1 JAG1 FGF11 FGF11 CNTF CNTF MDK MDK PROK1 PROK1 PGF PGF GDF15 GDF15 VEGFD VEGFD FBRS FBRS GDF5 GDF5 IL2 IL2 FGF13 FGF13 ENSCANP00000024374 ENSCANP00000024374 HDGF HDGF BMP3 BMP3 AMBN AMBN EFEMP1 EFEMP1 PDGFD PDGFD BMP7 BMP7 LOC105515980 LOC105515980 CCN2 CCN2 SPEM1 SPEM1 IL4 IL4 IL7 IL7 KITLG KITLG TGFB2 TGFB2 FGF12 FGF12 EREG EREG IGF1 IGF1 IL34 IL34 FGF19 FGF19 EGF EGF FGF9 FGF9 NRG4 NRG4 CD320 CD320 BMP15 BMP15 GMFB GMFB FAM71F1 FAM71F1 MSTN MSTN LACRT LACRT CDNF CDNF BDNF BDNF GDF2 GDF2 PDGFB PDGFB FGF16 FGF16 JAG2 JAG2 TIMP1 TIMP1 PSPN PSPN ENSCANP00000013830 ENSCANP00000013830 GDF6 GDF6 BMP4 BMP4 GDF7 GDF7 THPO THPO LOC105515982 LOC105515982 TFF1 TFF1 BMP2 BMP2 CSF1 CSF1 CSF2 CSF2 OSGIN2 OSGIN2 ENDOU ENDOU VEGFC VEGFC FGF17 FGF17 FGF6 FGF6 FGF5 FGF5 IL3 IL3 GDF9 GDF9 NRG2 NRG2 FGF20 FGF20 LOC105515984 LOC105515984 OSM OSM BMP6 BMP6 FGF8 FGF8 FGF22 FGF22 TGFB1 TGFB1 FGF10 FGF10 LOC105522005 LOC105522005 DKK1 DKK1 BMP5 BMP5 NGF NGF HDGFL3 HDGFL3 NTF3 NTF3 FGF23 FGF23 NTF4 NTF4 TGFA TGFA GDF10 GDF10 HBEGF HBEGF ENSCANP00000005566 ENSCANP00000005566 CLEC11A CLEC11A FGF21 FGF21 INHBA INHBA LOC105521177 LOC105521177 IGF2 IGF2 ENSCANP00000003895 ENSCANP00000003895 ANGPTL3 ANGPTL3 GDF11 GDF11 LIF LIF FGF1 FGF1 OGN OGN LOC105519161 LOC105519161 PPBP PPBP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPEM2SPEM family member 2. (502 aa)
CLCF1Cardiotrophin like cytokine factor 1. (223 aa)
INHBCInhibin subunit beta C. (352 aa)
IL11Interleukin 11. (199 aa)
BMP1Metalloendopeptidase. (980 aa)
AREGAmphiregulin. (275 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
IL6Interleukin 6. (214 aa)
NRG3Neuregulin 3. (627 aa)
CSPG5Chondroitin sulfate proteoglycan 5. (527 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (637 aa)
BTCBetacellulin. (178 aa)
FAM71F2Family with sequence similarity 71 member F2. (300 aa)
EPGNEpithelial mitogen. (154 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (197 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
OSGIN1Oxidative stress induced growth inhibitor 1. (556 aa)
MANFMesencephalic astrocyte derived neurotrophic factor. (150 aa)
RABEP2Rabaptin, RAB GTPase binding effector protein 2. (568 aa)
THBS4Thrombospondin 4. (961 aa)
IL9Interleukin 9. (145 aa)
NODALNodal growth differentiation factor. (347 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (345 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
LOC105516700TGF_BETA_2 domain-containing protein. (311 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (171 aa)
GRNGranulin precursor. (593 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
GDF3Growth differentiation factor 3. (364 aa)
RABEP1Rabaptin, RAB GTPase binding effector protein 1. (746 aa)
LOC105515982-2Uncharacterized protein. (139 aa)
BMP8BTGF_BETA_2 domain-containing protein. (336 aa)
MACC1MET transcriptional regulator MACC1. (852 aa)
GMFGGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (125 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ENSCANP00000030604Uncharacterized protein. (240 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (366 aa)
LOC105519388Uncharacterized protein. (118 aa)
ENSCANP00000030238Uncharacterized protein. (315 aa)
CSF3Colony stimulating factor 3. (207 aa)
INHBEInhibin subunit beta E. (351 aa)
PTNPleiotrophin. (172 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (412 aa)
GFERSulfhydryl oxidase. (130 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
CCN3Cellular communication network factor 3. (357 aa)
ENSCANP00000029034Uncharacterized protein. (145 aa)
ARTNArtemin. (158 aa)
GDF1TGF_BETA_2 domain-containing protein. (371 aa)
LOC105516701TGF_BETA_2 domain-containing protein. (283 aa)
NRG1Neuregulin 1. (645 aa)
GKN1Gastrokine 1. (199 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1089 aa)
FGF11Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (199 aa)
CNTFCiliary neurotrophic factor. (200 aa)
MDKUncharacterized protein. (164 aa)
PROK1Prokineticin 1. (105 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (200 aa)
GDF15Growth differentiation factor 15. (308 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
FBRSFibrosin. (841 aa)
GDF5Growth differentiation factor 5. (499 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
ENSCANP00000024374Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (166 aa)
HDGFUncharacterized protein. (211 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (472 aa)
AMBNAmeloblastin. (446 aa)
EFEMP1EGF containing fibulin extracellular matrix protein 1. (493 aa)
PDGFDPlatelet derived growth factor D. (370 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
LOC105515980Uncharacterized protein. (233 aa)
CCN2Cellular communication network factor 2. (301 aa)
SPEM1Spermatid maturation 1. (309 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (153 aa)
IL7Interleukin 7. (178 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
EREGEpiregulin. (169 aa)
IGF1Insulin like growth factor 1. (208 aa)
IL34Interleukin 34. (242 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (173 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NRG4Neuregulin 4. (115 aa)
CD320CD320 molecule. (264 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (150 aa)
FAM71F1Family with sequence similarity 71 member F1. (343 aa)
MSTNMyostatin. (376 aa)
LACRTLacritin. (137 aa)
CDNFCerebral dopamine neurotrophic factor. (187 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
GDF2Growth differentiation factor 2. (429 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (220 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1099 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
PSPNPersephin. (156 aa)
ENSCANP00000013830Uncharacterized protein. (148 aa)
GDF6Growth differentiation factor 6. (455 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GDF7Growth differentiation factor 7. (366 aa)
THPOThrombopoietin. (308 aa)
LOC105515982Uncharacterized protein. (217 aa)
TFF1Trefoil factor 1. (83 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (551 aa)
CSF2Colony stimulating factor 2. (144 aa)
OSGIN2Oxidative stress induced growth inhibitor family member 2. (547 aa)
ENDOUEndonuclease, poly(U) specific. (411 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (459 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (268 aa)
IL3Interleukin-3; Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. Belongs to the IL-3 family. (143 aa)
GDF9Growth differentiation factor 9. (366 aa)
NRG2Neuregulin 2. (671 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
LOC105515984Uncharacterized protein. (217 aa)
OSMOncostatin M. (252 aa)
BMP6Bone morphogenetic protein 6. (331 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (131 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC105522005Uncharacterized protein. (138 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (266 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (123 aa)
HDGFL3HDGF like 3. (196 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (278 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (251 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
TGFATransforming growth factor alpha. (166 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (474 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
ENSCANP00000005566Uncharacterized protein. (204 aa)
CLEC11AC-type lectin domain containing 11A. (260 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
INHBAInhibin subunit beta A. (426 aa)
LOC105521177TGF_BETA_2 domain-containing protein. (238 aa)
IGF2Insulin like growth factor 2. (236 aa)
ENSCANP00000003895Glia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (132 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
GDF11Growth differentiation factor 11. (345 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
OGNOsteoglycin. (253 aa)
LOC105519161CFC domain-containing protein. (170 aa)
PPBPC-X-C motif chemokine. (128 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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