STRINGSTRING
TTC21B TTC21B SHOX2 SHOX2 CREBBP CREBBP SHH SHH KCTD6 KCTD6 TXNDC15 TXNDC15 SERPINE2 SERPINE2 HHIP HHIP ENSCANP00000028625 ENSCANP00000028625 FUZ FUZ IFT140 IFT140 ARMC9 ARMC9 UCHL5 UCHL5 MGRN1 MGRN1 TCTN1 TCTN1 FBXL17 FBXL17 LOC105527362 LOC105527362 GPR37L1 GPR37L1 GPC3 GPC3 ZIC1 ZIC1 MKS1 MKS1 RUNX2 RUNX2 WDR11 WDR11 IFT81 IFT81 SFRP1 SFRP1 DHH DHH MEGF8 MEGF8 ENSCANP00000025951 ENSCANP00000025951 RFX4 RFX4 GPR161 GPR161 IHH IHH FOXA1 FOXA1 TUBD1 TUBD1 LOC105509618 LOC105509618 C2CD3 C2CD3 DLG5 DLG5 KCTD21 KCTD21 DYNC2H1 DYNC2H1 ENPP1 ENPP1 SMO SMO PRKACB PRKACB TTC23 TTC23 FGF10 FGF10 OTX2 OTX2 FAM92A FAM92A CPLANE2 CPLANE2 INTU INTU TULP3 TULP3 BTRC BTRC IFT122 IFT122 PTCH1 PTCH1 RAB34 RAB34 GLIS2 GLIS2 PTCH2 PTCH2 FGFR2 FGFR2 FGF9 FGF9 HERC4 HERC4 TEDC2 TEDC2 RACK1 RACK1 GLI3 GLI3 SUFU SUFU STK36 STK36 RPGRIP1L RPGRIP1L CHSY1 CHSY1 GAS8 GAS8 LOC105505011 LOC105505011 PRRX1 PRRX1 ENSCANP00000012904 ENSCANP00000012904 ULK3 ULK3 SCUBE1 SCUBE1 SCUBE2 SCUBE2 NDST1 NDST1 RORA RORA GLI1 GLI1 VCP VCP CD3E CD3E POR POR EVC EVC PDCL PDCL CTNNA1 CTNNA1 DCDC2 DCDC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TTC21BTetratricopeptide repeat domain 21B. (1316 aa)
SHOX2Short stature homeobox 2. (221 aa)
CREBBPCREB binding protein. (2117 aa)
SHHSonic hedgehog signaling molecule. (390 aa)
KCTD6Potassium channel tetramerization domain containing 6. (235 aa)
TXNDC15Thioredoxin domain containing 15. (360 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
HHIPHedgehog interacting protein. (700 aa)
ENSCANP00000028625Uncharacterized protein. (291 aa)
FUZFuzzy planar cell polarity protein. (418 aa)
IFT140Intraflagellar transport 140. (1470 aa)
ARMC9Armadillo repeat containing 9. (818 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (368 aa)
MGRN1Mahogunin ring finger 1. (492 aa)
TCTN1Tectonic family member 1. (587 aa)
FBXL17F-box and leucine rich repeat protein 17. (445 aa)
LOC105527362Uncharacterized protein. (835 aa)
GPR37L1G protein-coupled receptor 37 like 1. (481 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (603 aa)
ZIC1Zic family member 1. (373 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
RUNX2RUNX family transcription factor 2. (475 aa)
WDR11WD repeat domain 11. (1228 aa)
IFT81Intraflagellar transport 81. (676 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
MEGF8Multiple EGF like domains 8. (2837 aa)
ENSCANP00000025951Uncharacterized protein. (145 aa)
RFX4Regulatory factor X4. (675 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (549 aa)
IHHIndian hedgehog signaling molecule. (373 aa)
FOXA1Forkhead box A1. (447 aa)
TUBD1Tubulin delta 1; Belongs to the tubulin family. (453 aa)
LOC105509618BTB domain-containing protein. (260 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2353 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1896 aa)
KCTD21Potassium channel tetramerization domain containing 21. (260 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4248 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (868 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (768 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (398 aa)
TTC23Tetratricopeptide repeat domain 23. (449 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
OTX2Orthodenticle homeobox 2. (297 aa)
FAM92AFamily with sequence similarity 92 member A. (289 aa)
CPLANE2Ciliogenesis and planar polarity effector 2. (258 aa)
INTUInturned planar cell polarity protein. (942 aa)
TULP3TUB like protein 3; Belongs to the TUB family. (453 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (527 aa)
IFT122Intraflagellar transport 122. (1285 aa)
PTCH1Patched 1. (1449 aa)
RAB34RAB34, member RAS oncogene family. (268 aa)
GLIS2GLIS family zinc finger 2. (524 aa)
PTCH2Patched 2. (1207 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
HERC4HECT and RLD domain containing E3 ubiquitin protein ligase 4. (1057 aa)
TEDC2Tubulin epsilon and delta complex 2. (433 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (241 aa)
GLI3GLI family zinc finger 3. (1580 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
STK36Serine/threonine kinase 36. (1315 aa)
RPGRIP1LRPGRIP1 like. (1313 aa)
CHSY1Hexosyltransferase. (716 aa)
GAS8Growth arrest specific 8. (457 aa)
LOC105505011WD_REPEATS_REGION domain-containing protein. (312 aa)
PRRX1Paired related homeobox 1. (245 aa)
ENSCANP00000012904Uncharacterized protein. (90 aa)
ULK3Unc-51 like kinase 3. (482 aa)
SCUBE1Signal peptide, CUB domain and EGF like domain containing 1. (800 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (954 aa)
NDST1N-deacetylase and N-sulfotransferase 1. (882 aa)
RORARAR related orphan receptor A. (555 aa)
GLI1GLI family zinc finger 1. (1065 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (804 aa)
CD3ECD3e molecule. (198 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (676 aa)
EVCEvC ciliary complex subunit 1. (863 aa)
PDCLPhosducin like. (301 aa)
CTNNA1Catenin alpha 1. (906 aa)
DCDC2Doublecortin domain containing 2. (477 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.