STRINGSTRING
CHRNA10 CHRNA10 CASP5 CASP5 KCNC1 KCNC1 MDK MDK MAP3K1 MAP3K1 LRP11 LRP11 PKD2L1 PKD2L1 STAT1 STAT1 MTPN MTPN NPPA NPPA CNN2 CNN2 KCNK2 KCNK2 ATP8A2 ATP8A2 SLC1A3 SLC1A3 PIEZO2 PIEZO2 ADGRV1 ADGRV1 GSN GSN IRF1 IRF1 PLEC PLEC SLITRK6 SLITRK6 TLR4 TLR4 SLC8A1 SLC8A1 TIFAB TIFAB NEUROG1 NEUROG1 PPL PPL LOC105500957 LOC105500957 TNFRSF8 TNFRSF8 NTRK1 NTRK1 PTN PTN SERPINE2 SERPINE2 ETV1 ETV1 MYD88 MYD88 SCEL SCEL MAP3K14 MAP3K14 MAP1B MAP1B CAV3 CAV3 IHH IHH P2RY1 P2RY1 ENG ENG TLR7 TLR7 PKD2 PKD2 PAWR PAWR GCLC GCLC IL18 IL18 BCL10 BCL10 TRPV4 TRPV4 RYR2 RYR2 TGFBR2 TGFBR2 CD40 CD40 CHRNA9 CHRNA9 SLC26A5 SLC26A5 ANO3 ANO3 MAG MAG ENSCANP00000003460 ENSCANP00000003460 KCNA5 KCNA5 PDE2A PDE2A MAP3K2 MAP3K2 IL1B IL1B CLCN6 CLCN6 TNFRSF1A TNFRSF1A CASP2 CASP2 KIT KIT PKD1 PKD1 GADD45A GADD45A CXCL12 CXCL12 PTK2 PTK2 ENSCANP00000037159 ENSCANP00000037159 KCNQ1 KCNQ1 SLC2A1 SLC2A1 GATA4 GATA4 MEIS2 MEIS2 LTBR LTBR CASP8AP2 CASP8AP2 ITGA2 ITGA2 ENSCANP00000038043 ENSCANP00000038043 KIAA0319 KIAA0319 ANKRD1 ANKRD1 KCNC3 KCNC3 P2RX7 P2RX7 NRXN2 NRXN2 MAPK14 MAPK14 JUP JUP TACR1 TACR1 SRC SRC TTN TTN WHRN WHRN JUN JUN NRXN1 NRXN1 PJVK PJVK SCN1A SCN1A TMEM120A TMEM120A RELA RELA TNFSF14 TNFSF14 ANGPT2 ANGPT2 HPN HPN F11R F11R CRADD CRADD ENSCANP00000033842 ENSCANP00000033842 COL11A1 COL11A1 FOSL1 FOSL1 REST REST SOX9 SOX9 PKD1L1 PKD1L1 PKD2L2 PKD2L2 TLR3 TLR3 FOSB FOSB CHI3L1 CHI3L1 BACE1 BACE1 USP53 USP53 P2RX3 P2RX3 MAPK3 MAPK3 TNFRSF10A TNFRSF10A ASIC3 ASIC3 RPS6KB1 RPS6KB1 ENSCANP00000013830 ENSCANP00000013830 DDR2 DDR2 TBC1D31 TBC1D31 FADD FADD IGF1R IGF1R TRPA1 TRPA1 CASP8 CASP8 CNTNAP2 CNTNAP2 TMC2 TMC2 PIEZO1 PIEZO1 WNT11 WNT11 CTNNB1 CTNNB1 PTCH1 PTCH1 PTK2B PTK2B PDZD7 PDZD7 BDKRB1 BDKRB1 SHANK3 SHANK3 LHFPL5 LHFPL5 PCDH15 PCDH15 ANKRD23 ANKRD23 PTPRQ PTPRQ DCANP1 DCANP1 TLR8 TLR8 BMP6 BMP6 TGFB1 TGFB1 BAG3 BAG3 TMEM150C TMEM150C ASIC2 ASIC2 LOC105522005 LOC105522005 BNIP3 BNIP3 NFKBIA NFKBIA IGFBP2 IGFBP2 SOST SOST ENSCANP00000006830 ENSCANP00000006830 ENSCANP00000006395 ENSCANP00000006395 MKKS MKKS XPC XPC BAD BAD TCAP TCAP KCNK4 KCNK4 BAK1 BAK1 THBS1 THBS1 SLC9A1 SLC9A1 MAPK8 MAPK8 PKDREJ PKDREJ HTT HTT DMD DMD RETN RETN KRT5 KRT5 PKD1L3 PKD1L3 CITED2 CITED2 DAG1 DAG1 TMC1 TMC1 PTGS2 PTGS2 FOS FOS MAPK10 MAPK10 PTGER4 PTGER4 TNFRSF10B TNFRSF10B MBD2 MBD2 CSRP3 CSRP3 FYN FYN STRA6 STRA6 PIK3CA PIK3CA ENSCANP00000021758 ENSCANP00000021758 PHF24 PHF24 BTG2 BTG2 MAP2K4 MAP2K4 ABHD12 ABHD12 COL1A1 COL1A1 LOC105518456 LOC105518456 CYBA CYBA LRRIQ1 LRRIQ1 MPO MPO ITGB3 ITGB3 STRC STRC NFKB1 NFKB1 GDF5 GDF5 CASP1 CASP1 HABP4 HABP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHRNA10Cholinergic receptor nicotinic alpha 10 subunit. (450 aa)
CASP5Caspase 5; Belongs to the peptidase C14A family. (446 aa)
KCNC1Potassium voltage-gated channel subfamily C member 1; Belongs to the potassium channel family. (585 aa)
MDKUncharacterized protein. (164 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1356 aa)
LRP11LDL receptor related protein 11. (295 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (805 aa)
STAT1Signal transducer and activator of transcription. (765 aa)
MTPNMyotrophin. (118 aa)
NPPANatriuretic peptide A. (153 aa)
CNN2Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (288 aa)
KCNK2Potassium two pore domain channel subfamily K member 2; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (428 aa)
ATP8A2Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1141 aa)
SLC1A3Amino acid transporter. (542 aa)
PIEZO2Piezo-type mechanosensitive ion channel component. (2643 aa)
ADGRV1Adhesion G protein-coupled receptor V1; Belongs to the G-protein coupled receptor 2 family. (6305 aa)
GSNGelsolin. (773 aa)
IRF1Interferon regulatory factor. (325 aa)
PLECPlectin. (4128 aa)
SLITRK6SLIT and NTRK like family member 6. (841 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
TIFABTIFA inhibitor. (162 aa)
NEUROG1Neurogenin 1. (237 aa)
PPLPeriplakin. (1837 aa)
LOC105500957Uncharacterized protein; Belongs to the peptidase C14A family. (406 aa)
TNFRSF8TNF receptor superfamily member 8. (595 aa)
NTRK1Tyrosine-protein kinase receptor. (796 aa)
PTNPleiotrophin. (172 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (409 aa)
ETV1ETS variant 1. (508 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (317 aa)
SCELSciellin. (689 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (947 aa)
MAP1BMicrotubule associated protein 1B. (2465 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
IHHIndian hedgehog signaling molecule. (373 aa)
P2RY1Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (373 aa)
ENGEndoglin. (658 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1049 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (780 aa)
PAWRPro-apoptotic WT1 regulator. (340 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
BCL10BCL10 immune signaling adaptor. (233 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
RYR2Ryanodine receptor 2. (4920 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
CD40CD40 molecule. (278 aa)
CHRNA9Cholinergic receptor nicotinic alpha 9 subunit. (479 aa)
SLC26A5Prestin; Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (744 aa)
ANO3Anoctamin. (498 aa)
MAGMyelin associated glycoprotein. (626 aa)
ENSCANP00000003460Anoct_dimer domain-containing protein. (206 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (605 aa)
PDE2APhosphodiesterase. (936 aa)
MAP3K2Mitogen-activated protein kinase kinase kinase 2. (639 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
CLCN6Chloride voltage-gated channel 6; Belongs to the chloride channel (TC 2.A.49) family. (878 aa)
TNFRSF1ATNF receptor superfamily member 1A. (455 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (404 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4053 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1096 aa)
ENSCANP00000037159Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (113 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (612 aa)
SLC2A1Solute carrier family 2 member 1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (486 aa)
GATA4GATA binding protein 4. (236 aa)
MEIS2Meis homeobox 2. (477 aa)
LTBRLymphotoxin beta receptor. (435 aa)
CASP8AP2Caspase 8 associated protein 2. (1985 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
ENSCANP00000038043Uncharacterized protein. (107 aa)
KIAA0319KIAA0319. (1072 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
KCNC3Potassium voltage-gated channel subfamily C member 3; Belongs to the potassium channel family. (428 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
NRXN2Neurexin 2. (1468 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
JUPJunction plakoglobin. (746 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
SRCTyrosine-protein kinase. (458 aa)
TTNTitin. (32000 aa)
WHRNWhirlin. (907 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
NRXN1Neurexin 1. (1507 aa)
PJVKPejvakin. (352 aa)
SCN1ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
TMEM120ATransmembrane protein 120A. (343 aa)
RELARELA proto-oncogene, NF-kB subunit. (548 aa)
TNFSF14TNF superfamily member 14; Belongs to the tumor necrosis factor family. (240 aa)
ANGPT2Angiopoietin 2. (496 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
F11RF11 receptor. (322 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (199 aa)
ENSCANP00000033842Calponin-homology (CH) domain-containing protein. (140 aa)
COL11A1Collagen type XI alpha 1 chain. (1764 aa)
FOSL1FOS like 1, AP-1 transcription factor subunit. (271 aa)
RESTRE1 silencing transcription factor. (1096 aa)
SOX9SRY-box transcription factor 9. (509 aa)
PKD1L1Polycystin 1 like 1, transient receptor potential channel interacting. (2837 aa)
PKD2L2Polycystin 2 like 2, transient receptor potential cation channel. (624 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (904 aa)
FOSBFosB proto-oncogene, AP-1 transcription factor subunit. (338 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (405 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
USP53Ubiquitin specific peptidase 53. (1072 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (395 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
TNFRSF10ATNF receptor superfamily member 10a. (469 aa)
ASIC3Acid sensing ion channel subunit 3; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (547 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
ENSCANP00000013830Uncharacterized protein. (148 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
TBC1D31TBC1 domain family member 31. (1008 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (200 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1116 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (538 aa)
CNTNAP2Contactin associated protein like 2. (1331 aa)
TMC2Transmembrane channel-like protein. (905 aa)
PIEZO1Piezo-type mechanosensitive ion channel component. (2502 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (330 aa)
CTNNB1Catenin beta 1. (781 aa)
PTCH1Patched 1. (1449 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
PDZD7PDZ domain containing 7. (984 aa)
BDKRB1Bradykinin receptor B1. (283 aa)
SHANK3SH3 and multiple ankyrin repeat domains 3. (1426 aa)
LHFPL5LHFPL tetraspan subfamily member 5. (237 aa)
PCDH15Protocadherin related 15. (1959 aa)
ANKRD23Ankyrin repeat domain 23. (305 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (2332 aa)
DCANP1Dendritic cell associated nuclear protein. (214 aa)
TLR8Toll like receptor 8; Belongs to the Toll-like receptor family. (1041 aa)
BMP6Bone morphogenetic protein 6. (331 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
BAG3BCL2 associated athanogene 3. (515 aa)
TMEM150CTransmembrane protein 150C. (249 aa)
ASIC2Acid sensing ion channel subunit 2; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (512 aa)
LOC105522005Uncharacterized protein. (138 aa)
BNIP3BCL2 interacting protein 3. (185 aa)
NFKBIANFKB inhibitor alpha. (317 aa)
IGFBP2Insulin like growth factor binding protein 2. (181 aa)
SOSTSclerostin. (213 aa)
ENSCANP00000006830Protein kinase domain-containing protein. (373 aa)
ENSCANP00000006395Calponin-homology (CH) domain-containing protein. (225 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (939 aa)
BADBCL2 associated agonist of cell death. (167 aa)
TCAPTitin-cap. (167 aa)
KCNK4Potassium two pore domain channel subfamily K member 4; Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. (357 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
THBS1Thrombospondin 1. (1173 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
PKDREJPolycystin family receptor for egg jelly. (2092 aa)
HTTHuntingtin. (3037 aa)
DMDDystrophin. (3660 aa)
RETNResistin. (108 aa)
KRT5Keratin 5; Belongs to the intermediate filament family. (589 aa)
PKD1L3Polycystin 1 like 3, transient receptor potential channel interacting. (1574 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
DAG1Dystroglycan 1. (894 aa)
TMC1Transmembrane channel-like protein. (769 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (380 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
TNFRSF10BTNF receptor superfamily member 10b. (444 aa)
MBD2Methyl-CpG binding domain protein 2. (230 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
FYNTyrosine-protein kinase. (537 aa)
STRA6Stimulated by retinoic acid 6. (706 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ENSCANP00000021758Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (284 aa)
PHF24PHD finger protein 24. (400 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (373 aa)
ABHD12Abhydrolase domain containing 12. (340 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
LOC105518456Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (301 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
LRRIQ1Leucine rich repeats and IQ motif containing 1. (1694 aa)
MPOMyeloperoxidase. (745 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
STRCStereocilin. (1534 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
GDF5Growth differentiation factor 5. (499 aa)
CASP1Caspase 1; Belongs to the peptidase C14A family. (372 aa)
HABP4Hyaluronan binding protein 4. (371 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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