STRINGSTRING
SIN3A SIN3A ILDR2 ILDR2 PDK3 PDK3 MAP2K4 MAP2K4 PRKCB PRKCB TH TH EIF2B2 EIF2B2 CCN2 CCN2 RASAL2 RASAL2 HNF1A HNF1A CYBA CYBA TWNK TWNK XBP1 XBP1 GPER1 GPER1 AGER AGER SARM1 SARM1 CDKN1B CDKN1B NKX2-2 NKX2-2 PNPLA3 PNPLA3 SLC26A6 SLC26A6 SRF SRF LOC105510459 LOC105510459 ADIPOQ ADIPOQ ADCY8 ADCY8 PRKAA2 PRKAA2 ACVR2B ACVR2B SESN2 SESN2 HIF1A HIF1A ERCC1 ERCC1 SLC8A1 SLC8A1 PPP3CA PPP3CA SMAD4 SMAD4 MAP1B MAP1B THBS1 THBS1 GIP GIP RUNX2 RUNX2 GCKR GCKR SLC12A6 SLC12A6 PTPRN PTPRN GYS2 GYS2 ZNF236 ZNF236 PTPRN2 PTPRN2 PTGS2 PTGS2 GAS6 GAS6 ENSCANP00000018874 ENSCANP00000018874 PPARD PPARD FKBP1B FKBP1B COL4A3 COL4A3 ERN1 ERN1 PCK1 PCK1 TCF7L2 TCF7L2 SELENOT SELENOT CALCRL CALCRL MAP2K3 MAP2K3 ADNP ADNP PIK3CA PIK3CA PAX2 PAX2 RACK1 RACK1 ZFP36L1 ZFP36L1 SLC30A8 SLC30A8 P2RX3 P2RX3 GPLD1 GPLD1 SELENOS SELENOS RESP18 RESP18 GIPR GIPR CPB2 CPB2 ENSCANP00000032068 ENSCANP00000032068 TRA2B TRA2B GRIK5 GRIK5 HMGCS2 HMGCS2 KAT7 KAT7 ANGPT2 ANGPT2 ME1 ME1 MAPK13 MAPK13 EGR1 EGR1 TXN2 TXN2 LYN LYN GCLM GCLM SLC39A14 SLC39A14 PRLH PRLH SLC2A5 SLC2A5 SLC12A7 SLC12A7 RAB11FIP5 RAB11FIP5 PLCB1 PLCB1 EIF2B5 EIF2B5 SMAD2 SMAD2 ZBTB20 ZBTB20 GATA4 GATA4 P2RX2 P2RX2 CCDC186 CCDC186 SREBF1 SREBF1 RPS6KB1 RPS6KB1 RPS6KA2 RPS6KA2 SLC37A4 SLC37A4 LPL LPL LOC105505011 LOC105505011 SLC29A1 SLC29A1 ITGA2 ITGA2 GHRHR GHRHR IGF1R IGF1R LIN28A LIN28A AQP4 AQP4 SERPINF1 SERPINF1 NPTX1 NPTX1 CASR CASR PRKAA1 PRKAA1 PTK2B PTK2B EIF2B4 EIF2B4 HNF4A HNF4A PCSK1 PCSK1 SIDT2 SIDT2 APOA2 APOA2 NR0B2 NR0B2 CDT1 CDT1 FN1 FN1 KCNB1 KCNB1 MLXIPL MLXIPL TGFB1 TGFB1 SLC6A1 SLC6A1 ACVR1C ACVR1C TJP1 TJP1 GPAM GPAM MAP2K6 MAP2K6 ENSCANP00000006830 ENSCANP00000006830 RBM4B RBM4B CYP7A1 CYP7A1 GLUL GLUL ENSCANP00000005382 ENSCANP00000005382 FGF21 FGF21 BAD BAD TGFBR2 TGFBR2 GJB6 GJB6 GCK GCK TREM2 TREM2 PKLR PKLR RAB11FIP2 RAB11FIP2 NEUROD1 NEUROD1 PFKL PFKL PCK2 PCK2 MAP2K7 MAP2K7 MEN1 MEN1 COL6A2 COL6A2 RMI1 RMI1 GCLC GCLC APOB APOB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIN3ASIN3 transcription regulator family member A. (1273 aa)
ILDR2Immunoglobulin like domain containing receptor 2. (565 aa)
PDK3Protein-serine/threonine kinase. (419 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (373 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
THTyrosine hydroxylase. (529 aa)
EIF2B2Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (351 aa)
CCN2Cellular communication network factor 2. (301 aa)
RASAL2RAS protein activator like 2. (1280 aa)
HNF1AHNF1 homeobox A. (662 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
TWNKTwinkle mtDNA helicase. (582 aa)
XBP1X-box binding protein 1. (204 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
SARM1Sterile alpha and TIR motif containing 1. (594 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
NKX2-2NK2 homeobox 2. (273 aa)
PNPLA3Patatin like phospholipase domain containing 3. (418 aa)
SLC26A6Solute carrier family 26 member 6. (758 aa)
SRFSerum response factor. (406 aa)
LOC105510459Collectrin domain-containing protein. (222 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1251 aa)
PRKAA2Non-specific serine/threonine protein kinase. (545 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (750 aa)
SESN2Sestrin 2. (479 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (827 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (298 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MAP1BMicrotubule associated protein 1B. (2465 aa)
THBS1Thrombospondin 1. (1173 aa)
GIPGLUCAGON domain-containing protein. (79 aa)
RUNX2RUNX family transcription factor 2. (475 aa)
GCKRGlucokinase regulator. (437 aa)
SLC12A6Solute carrier family 12 member 6. (1150 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (979 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (703 aa)
ZNF236Zinc finger protein 236. (1845 aa)
PTPRN2Protein tyrosine phosphatase receptor type N2. (977 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
GAS6Growth arrest specific 6. (593 aa)
ENSCANP00000018874Uncharacterized protein. (195 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
COL4A3Collagen type IV alpha 3 chain. (1646 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (979 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
TCF7L2Transcription factor 7 like 2. (577 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (195 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (461 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
ADNPActivity dependent neuroprotector homeobox. (1103 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PAX2Paired box 2. (388 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (241 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (395 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (841 aa)
SELENOSSelenoprotein S. (188 aa)
RESP18Regulated endocrine specific protein 18. (228 aa)
GIPRGastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (249 aa)
CPB2Carboxypeptidase B2. (423 aa)
ENSCANP00000032068Uncharacterized protein. (186 aa)
TRA2BTransformer 2 beta homolog. (259 aa)
GRIK5Glutamate ionotropic receptor kainate type subunit 5. (952 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (508 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
ANGPT2Angiopoietin 2. (496 aa)
ME1Malic enzyme. (572 aa)
MAPK13Mitogen-activated protein kinase. (491 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (527 aa)
TXN2Thioredoxin 2. (166 aa)
LYNTyrosine-protein kinase. (512 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (262 aa)
SLC39A14Solute carrier family 39 member 14. (490 aa)
PRLHProlactin releasing hormone. (87 aa)
SLC2A5Solute carrier family 2 member 5; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (501 aa)
SLC12A7Solute carrier family 12 member 7. (875 aa)
RAB11FIP5FIP-RBD domain-containing protein. (1301 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1173 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (728 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ZBTB20Zinc finger and BTB domain containing 20. (741 aa)
GATA4GATA binding protein 4. (236 aa)
P2RX2P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
CCDC186Coiled-coil domain containing 186. (898 aa)
SREBF1Sterol regulatory element binding transcription factor 1. (1148 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
LOC105505011WD_REPEATS_REGION domain-containing protein. (312 aa)
SLC29A1Solute carrier family 29 member 1 (Augustine blood group). (456 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (414 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
LIN28ALin-28 homolog A. (209 aa)
AQP4Aquaporin 4; Belongs to the MIP/aquaporin (TC 1.A.8) family. (323 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (366 aa)
NPTX1Neuronal pentraxin 1. (414 aa)
CASRCalcium sensing receptor. (1088 aa)
PRKAA1Non-specific serine/threonine protein kinase. (574 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
EIF2B4Eukaryotic translation initiation factor 2B subunit delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (543 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (464 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (749 aa)
SIDT2SID1 transmembrane family member 2. (855 aa)
APOA2Apolipoprotein A2. (100 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (257 aa)
CDT1Chromatin licensing and DNA replication factor 1. (470 aa)
FN1Fibronectin 1. (2450 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (818 aa)
MLXIPLMLX interacting protein like. (852 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (599 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (489 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1762 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
ENSCANP00000006830Protein kinase domain-containing protein. (373 aa)
RBM4BRNA binding motif protein 4B. (359 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
GLULGlutamine synthetase. (373 aa)
ENSCANP00000005382Thioredoxin domain-containing protein. (185 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
BADBCL2 associated agonist of cell death. (167 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa)
GCKPhosphotransferase. (466 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
RAB11FIP2RAB11 family interacting protein 2. (532 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (767 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (468 aa)
MEN1Menin 1. (610 aa)
COL6A2Collagen type VI alpha 2 chain. (947 aa)
RMI1RecQ mediated genome instability 1. (625 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
APOBApolipoprotein B. (4555 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.