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TGFB2 TGFB2 BCL9L BCL9L LRG1 LRG1 RGCC RGCC EZH2 EZH2 TCF7L2 TCF7L2 ENSCANP00000013830 ENSCANP00000013830 BMP4 BMP4 DAB2 DAB2 BMP2 BMP2 ACVR1 ACVR1 CTNNB1 CTNNB1 TIAM1 TIAM1 EMP2 EMP2 OLFM1 OLFM1 TGFB1 TGFB1 LOC105522005 LOC105522005 ENSCANP00000006850 ENSCANP00000006850 TGFBR2 TGFBR2 ENSCANP00000004166 ENSCANP00000004166 ENG ENG BAMBI BAMBI SDCBP SDCBP AXIN2 AXIN2 SMAD3 SMAD3 LEF1 LEF1 LOXL2 LOXL2 ZNF703 ZNF703 FERMT2 FERMT2 MTOR MTOR COL1A1 COL1A1 BMP7 BMP7 ALX1 ALX1 HDAC2 HDAC2 SNAI1 SNAI1 MDK MDK TGFB1I1 TGFB1I1 JAG1 JAG1 PDPN PDPN NOTCH1 NOTCH1 SMAD4 SMAD4 GLIPR2 GLIPR2 TGFBR1 TGFBR1 WWTR1 WWTR1 GCNT2 GCNT2 IL1B IL1B TGFB3 TGFB3 TBX20 TBX20 SMAD2 SMAD2 ISL1 ISL1 IL6 IL6 CRB2 CRB2 ENSCANP00000038657 ENSCANP00000038657
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BCL9LBCL9 like. (1463 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
RGCCRegulator of cell cycle. (208 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
TCF7L2Transcription factor 7 like 2. (577 aa)
ENSCANP00000013830Uncharacterized protein. (148 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
DAB2DAB adaptor protein 2. (770 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
CTNNB1Catenin beta 1. (781 aa)
TIAM1T cell lymphoma invasion and metastasis 1. (1591 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (200 aa)
OLFM1Olfactomedin 1. (467 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
LOC105522005Uncharacterized protein. (138 aa)
ENSCANP00000006850PDZ domain-containing protein. (282 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
ENSCANP00000004166PDZ domain-containing protein. (294 aa)
ENGEndoglin. (658 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
SDCBPSyndecan binding protein. (318 aa)
AXIN2Axin 2. (843 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
LOXL2Lysyl oxidase like 2. (774 aa)
ZNF703Zinc finger protein 703. (567 aa)
FERMT2Fermitin family member 2. (687 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
COL1A1Collagen type I alpha 1 chain. (1464 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
ALX1ALX homeobox 1. (326 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
SNAI1Snail family transcriptional repressor 1. (264 aa)
MDKUncharacterized protein. (164 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1089 aa)
PDPNPodoplanin. (217 aa)
NOTCH1Notch receptor 1. (2559 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (165 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
GCNT2Glucosaminyl (N-acetyl) transferase 2 (I blood group). (402 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (269 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
TBX20T-box transcription factor 20. (447 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ISL1ISL LIM homeobox 1. (349 aa)
IL6Interleukin 6. (214 aa)
CRB2Crumbs cell polarity complex component 2. (1287 aa)
ENSCANP00000038657Fork-head domain-containing protein. (200 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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