node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGT | AGTR1 | ENSCANP00000013314 | ENSCANP00000036402 | Angiotensinogen; Belongs to the serpin family. | Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. | 0.994 |
AGTR1 | AGT | ENSCANP00000036402 | ENSCANP00000013314 | Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. | Angiotensinogen; Belongs to the serpin family. | 0.994 |
AGTR1 | APOB | ENSCANP00000036402 | ENSCANP00000000289 | Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. | Apolipoprotein B. | 0.575 |
ALOX15B | PLA2G2A | ENSCANP00000031083 | ENSCANP00000025413 | Arachidonate 15-lipoxygenase type B. | Phospholipase A(2). | 0.834 |
ALOX15B | PLA2G3 | ENSCANP00000031083 | ENSCANP00000014681 | Arachidonate 15-lipoxygenase type B. | Phospholipase A2 group III. | 0.830 |
APOB | AGTR1 | ENSCANP00000000289 | ENSCANP00000036402 | Apolipoprotein B. | Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. | 0.575 |
APOB | CD36 | ENSCANP00000000289 | ENSCANP00000033730 | Apolipoprotein B. | CD36 molecule; Belongs to the CD36 family. | 0.859 |
APOB | LPL | ENSCANP00000000289 | ENSCANP00000013730 | Apolipoprotein B. | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. | 0.764 |
APOB | MSR1 | ENSCANP00000000289 | ENSCANP00000008056 | Apolipoprotein B. | Macrophage scavenger receptor 1. | 0.412 |
APOB | PLA2G5 | ENSCANP00000000289 | ENSCANP00000023004 | Apolipoprotein B. | Phospholipase A(2). | 0.542 |
CD36 | APOB | ENSCANP00000033730 | ENSCANP00000000289 | CD36 molecule; Belongs to the CD36 family. | Apolipoprotein B. | 0.859 |
CD36 | LPL | ENSCANP00000033730 | ENSCANP00000013730 | CD36 molecule; Belongs to the CD36 family. | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. | 0.542 |
CD36 | MSR1 | ENSCANP00000033730 | ENSCANP00000008056 | CD36 molecule; Belongs to the CD36 family. | Macrophage scavenger receptor 1. | 0.455 |
CSF1 | CSF2 | ENSCANP00000012611 | ENSCANP00000012163 | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | Colony stimulating factor 2. | 0.612 |
CSF2 | CSF1 | ENSCANP00000012163 | ENSCANP00000012611 | Colony stimulating factor 2. | Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] | 0.612 |
CSF2 | IL18 | ENSCANP00000012163 | ENSCANP00000000257 | Colony stimulating factor 2. | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. | 0.528 |
IL18 | CSF2 | ENSCANP00000000257 | ENSCANP00000012163 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. | Colony stimulating factor 2. | 0.528 |
IL18 | NFKB1 | ENSCANP00000000257 | ENSCANP00000024773 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. | Nuclear factor kappa B subunit 1. | 0.840 |
LPL | APOB | ENSCANP00000013730 | ENSCANP00000000289 | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. | Apolipoprotein B. | 0.764 |
LPL | CD36 | ENSCANP00000013730 | ENSCANP00000033730 | Lipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. | CD36 molecule; Belongs to the CD36 family. | 0.542 |