STRINGSTRING
LOC105509542 LOC105509542 BCOR BCOR UBR2 UBR2 TRIM37 TRIM37 PCGF5 PCGF5 PCGF3 PCGF3 DTX3L DTX3L ENSCANP00000033944 ENSCANP00000033944 SUZ12 SUZ12 LOC105527518 LOC105527518 WAC WAC RYBP RYBP LOC105515808 LOC105515808 CDC73 CDC73 RAG1 RAG1 PCGF2 PCGF2 LOC105513286 LOC105513286 DDB2 DDB2 RNF2 RNF2 RNF20 RNF20 CTR9 CTR9 LOC105516447 LOC105516447 LOC105525747 LOC105525747 SKP1 SKP1 BARD1 BARD1 ENSCANP00000025746 ENSCANP00000025746 RNF168 RNF168 PCGF1 PCGF1 RAD51 RAD51 UBE2A UBE2A UHRF1 UHRF1 RNF40 RNF40 UBE2N UBE2N UBE2E1 UBE2E1 PHC1 PHC1 ENSCANP00000018891 ENSCANP00000018891 DDB1 DDB1 RNF8 RNF8 HUWE1 HUWE1 RING1 RING1 LEO1 LEO1 BRCA2 BRCA2 UBE2B UBE2B ATXN7L3 ATXN7L3 CUL4B CUL4B PCGF6 PCGF6 ENSCANP00000013426 ENSCANP00000013426 KDM2B KDM2B CBX8 CBX8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105509542UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
BCORBCL6 corepressor. (1755 aa)
UBR2E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1703 aa)
TRIM37Tripartite motif containing 37. (956 aa)
PCGF5Polycomb group ring finger 5. (256 aa)
PCGF3Polycomb group ring finger 3. (242 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (687 aa)
ENSCANP00000033944Uncharacterized protein; Belongs to the SKP1 family. (131 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (632 aa)
LOC105527518RING-type domain-containing protein. (326 aa)
WACWW domain containing adaptor with coiled-coil. (633 aa)
RYBPRING1 and YY1 binding protein. (230 aa)
LOC105515808UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
CDC73Cell division cycle 73. (531 aa)
RAG1V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T- lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break [...] (1043 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
LOC105513286UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
RNF2Ring finger protein 2. (336 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
LOC105516447UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
LOC105525747UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (89 aa)
SKP1S-phase kinase associated protein 1; Belongs to the SKP1 family. (165 aa)
BARD1BRCA1 associated RING domain 1. (718 aa)
ENSCANP00000025746Uncharacterized protein; Belongs to the SKP1 family. (167 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
PCGF1Polycomb group ring finger 1. (259 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (299 aa)
UBE2AUbiquitin conjugating enzyme E2 A; Belongs to the ubiquitin-conjugating enzyme family. (152 aa)
UHRF1Ubiquitin like with PHD and ring finger domains 1. (850 aa)
RNF40E3 ubiquitin protein ligase; Belongs to the BRE1 family. (1001 aa)
UBE2NUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (142 aa)
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
PHC1Polyhomeotic homolog 1. (1004 aa)
ENSCANP00000018891Uncharacterized protein; Belongs to the SKP1 family. (137 aa)
DDB1Damage specific DNA binding protein 1. (1147 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4400 aa)
RING1Ring finger protein 1. (406 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa)
BRCA2BRCA2 DNA repair associated. (3412 aa)
UBE2BUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (138 aa)
ATXN7L3Ataxin 7 like 3. (219 aa)
CUL4BCullin 4B; Belongs to the cullin family. (870 aa)
PCGF6Polycomb group ring finger 6. (288 aa)
ENSCANP00000013426RING-type domain-containing protein. (324 aa)
KDM2BLysine demethylase 2B. (1336 aa)
CBX8Chromobox 8. (387 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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