(59 nodes) Ligase activity, forming carbon-nitrogen bonds network (Colobus angolensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TTLL4	Tubulin tyrosine ligase like 4. (1199 aa)
	TTL	Uncharacterized protein. (356 aa)
	ENSCANP00000000620	ATP-grasp domain-containing protein. (386 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (637 aa)
	PFAS	Phosphoribosylformylglycinamidine synthase. (1335 aa)
	GART	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (990 aa)
	PAICS	Uncharacterized protein. (304 aa)
	TTLL1	Tubulin tyrosine ligase like 1. (385 aa)
	ENSCANP00000003496	Uncharacterized protein. (86 aa)
	ASNS	Asparagine synthetase [glutamine-hydrolyzing]. (561 aa)
	GLUL	Glutamine synthetase. (373 aa)
	QRSL1-2	Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily. (508 aa)
	GHDC	GH3 domain containing. (473 aa)
	CPS1	Carbamoyl-phosphate synthase 1. (1507 aa)
	TTLL6	Tubulin tyrosine ligase like 6. (869 aa)
	ASS1	Argininosuccinate synthase 1. (391 aa)
	GMPS	Guanine monophosphate synthase. (606 aa)
	RIMKLB	Ribosomal modification protein rimK like family member B. (386 aa)
	GATB	Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily. (557 aa)
	ASNSD1	Glutamine amidotransferase type-2 domain-containing protein. (643 aa)
	TTLL11	Tubulin tyrosine ligase like 11. (696 aa)
	CTPS2	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (583 aa)
	GATC	Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatC family. (136 aa)
	ADSS2	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
	LOC105519059	Uncharacterized protein. (810 aa)
	TTLL8	Tubulin tyrosine ligase like 8. (793 aa)
	NAPRT	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (462 aa)
	ENSCANP00000018874	Uncharacterized protein. (195 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (896 aa)
	LOC105507807	AIRC domain-containing protein. (450 aa)
	TTLL10	Tubulin tyrosine ligase like 10. (650 aa)
	CAD	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase. (2225 aa)
	ENSCANP00000020568	Uncharacterized protein. (455 aa)
	QRSL1	Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the amidase family. GatA subfamily. (563 aa)
	NADSYN1	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (706 aa)
	GSS	Glutathione synthetase. (474 aa)
	TTLL5	Tubulin tyrosine ligase like 5. (1304 aa)
	CARNS1	Carnosine synthase 1. (813 aa)
	MCCC1	Methylcrotonoyl-CoA carboxylase 1. (616 aa)
	TTLL9	Tubulin tyrosine ligase like 9. (438 aa)
	LGSN	Lengsin, lens protein with glutamine synthetase domain; Belongs to the glutamine synthetase family. (507 aa)
	CTPS1	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (592 aa)
	TTLL7	Tubulin tyrosine ligase like 7. (887 aa)
	MROH6	Maestro heat like repeat family member 6. (672 aa)
	ENSCANP00000032715	Uncharacterized protein. (321 aa)
	ENSCANP00000032753	RimK domain-containing protein. (344 aa)
	CCDC30	Coiled-coil domain containing 30. (765 aa)
	ST20-MTHFS	5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (225 aa)
	GCLM	Glutamate-cysteine ligase modifier subunit. (262 aa)
	ENSCANP00000035521	THF_DHG_CYH_C domain-containing protein. (873 aa)
	TTLL2	Tubulin tyrosine ligase like 2. (544 aa)
	PPCS	Phosphopantothenoylcysteine synthetase. (311 aa)
	ADSS1	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (499 aa)
	MTHFD1	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (986 aa)
	ENSCANP00000038566	Uncharacterized protein. (400 aa)
	RIMKLA	Ribosomal modification protein rimK like family member A. (386 aa)
	HLCS	Holocarboxylase synthetase. (726 aa)
	DPH6	Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. (267 aa)
	FPGS	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (570 aa)

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADSS1	ADSS2	ENSCANP00000037627	ENSCANP00000015659	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	0.820
ADSS1	ASNS	ENSCANP00000037627	ENSCANP00000004827	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Asparagine synthetase [glutamine-hydrolyzing].	0.888
ADSS1	ASNSD1	ENSCANP00000037627	ENSCANP00000011806	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Glutamine amidotransferase type-2 domain-containing protein.	0.671
ADSS1	ASS1	ENSCANP00000037627	ENSCANP00000007846	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Argininosuccinate synthase 1.	0.722
ADSS1	CAD	ENSCANP00000037627	ENSCANP00000019729	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	0.915
ADSS1	CPS1	ENSCANP00000037627	ENSCANP00000005757	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Carbamoyl-phosphate synthase 1.	0.832
ADSS1	CTPS1	ENSCANP00000037627	ENSCANP00000030610	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.587
ADSS1	CTPS2	ENSCANP00000037627	ENSCANP00000014800	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.	0.587
ADSS1	ENSCANP00000020568	ENSCANP00000037627	ENSCANP00000020568	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Uncharacterized protein.	0.696
ADSS1	ENSCANP00000032715	ENSCANP00000037627	ENSCANP00000032715	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Uncharacterized protein.	0.722
ADSS1	ENSCANP00000038566	ENSCANP00000037627	ENSCANP00000038566	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Uncharacterized protein.	0.647
ADSS1	GART	ENSCANP00000037627	ENSCANP00000001312	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Trifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family.	0.982
ADSS1	GMPS	ENSCANP00000037627	ENSCANP00000008672	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Guanine monophosphate synthase.	0.631
ADSS1	LOC105507807	ENSCANP00000037627	ENSCANP00000019707	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	AIRC domain-containing protein.	0.862
ADSS1	PAICS	ENSCANP00000037627	ENSCANP00000002501	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	Uncharacterized protein.	0.862
ADSS2	ADSS1	ENSCANP00000015659	ENSCANP00000037627	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.	0.820
ADSS2	ASNS	ENSCANP00000015659	ENSCANP00000004827	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Asparagine synthetase [glutamine-hydrolyzing].	0.888
ADSS2	ASNSD1	ENSCANP00000015659	ENSCANP00000011806	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Glutamine amidotransferase type-2 domain-containing protein.	0.671
ADSS2	ASS1	ENSCANP00000015659	ENSCANP00000007846	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Argininosuccinate synthase 1.	0.660
ADSS2	CAD	ENSCANP00000015659	ENSCANP00000019729	Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.	Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase.	0.915