STRINGSTRING
POLR2D POLR2D ENSCANP00000000135 ENSCANP00000000135 DCP1A DCP1A DAPK3 DAPK3 SHMT1 SHMT1 DIS3 DIS3 MLH1 MLH1 ZFP36 ZFP36 NANOS2 NANOS2 LOC105526708 LOC105526708 ZNF540 ZNF540 PATL2 PATL2 ILF3 ILF3 CNOT3 CNOT3 LOC105523217 LOC105523217 ENSCANP00000004241 ENSCANP00000004241 LRRC27 LRRC27 KHSRP KHSRP YTHDF2 YTHDF2 PLEKHN1 PLEKHN1 TSC1 TSC1 SAMD4B SAMD4B AGO4 AGO4 ENSCANP00000005215 ENSCANP00000005215 HNRNPD HNRNPD PAN2 PAN2 ENSCANP00000005498 ENSCANP00000005498 LSM1 LSM1 ENSCANP00000005698 ENSCANP00000005698 EIF4EBP1 EIF4EBP1 RBM4B RBM4B ENC1 ENC1 EPRS1 EPRS1 PML PML SYNCRIP SYNCRIP CNOT6 CNOT6 EIF2S1 EIF2S1 FTO FTO ENSCANP00000008732 ENSCANP00000008732 ENSCANP00000009029 ENSCANP00000009029 ENSCANP00000009286 ENSCANP00000009286 LOC105508378 LOC105508378 CNOT6L CNOT6L ZC3H12D ZC3H12D LSM14A LSM14A RIDA RIDA PARN PARN YTHDF1 YTHDF1 FXR1 FXR1 ENSCANP00000011836 ENSCANP00000011836 CNOT4 CNOT4 C8orf88 C8orf88 IREB2 IREB2 EIF4ENIF1 EIF4ENIF1 ENSCANP00000012626 ENSCANP00000012626 LIN28A LIN28A UPF1 UPF1 RBM24 RBM24 DCP2 DCP2 ENSCANP00000013869 ENSCANP00000013869 SRP9 SRP9 TNRC6B TNRC6B EIF2AK1 EIF2AK1 AGO2 AGO2 ROCK1 ROCK1 DDX3X DDX3X MALSU1 MALSU1 ZFP36L1 ZFP36L1 TIA1 TIA1 ENSCANP00000016366 ENSCANP00000016366 GAPDH GAPDH RARA RARA CPEB1 CPEB1 LOC105507012 LOC105507012 DCPS DCPS NOCT NOCT ENSCANP00000017238 ENSCANP00000017238 ENSCANP00000017240 ENSCANP00000017240 RC3H1 RC3H1 LOC105514134 LOC105514134 ENSCANP00000017887 ENSCANP00000017887 IGF2BP1 IGF2BP1 YTHDF3 YTHDF3 CAPRIN1 CAPRIN1 LOC105512634 LOC105512634 SHMT2 SHMT2 ENSCANP00000019087 ENSCANP00000019087 BANK1 BANK1 PAN3 PAN3 AGO3 AGO3 SHFL SHFL UNK UNK EIF4G1 EIF4G1 PNPT1 PNPT1 BTG2 BTG2 FMR1 FMR1 PRG3 PRG3 SAMD4A SAMD4A NANOS3 NANOS3 EIF2AK3 EIF2AK3 CAPRIN2 CAPRIN2 METTL16 METTL16 YBX1 YBX1 EIF6 EIF6 EIF4EBP2 EIF4EBP2 TUT7 TUT7 RNF139 RNF139 DCP1B DCP1B RPS3 RPS3 RGS2 RGS2 IGF2BP3 IGF2BP3 EIF4EBP3 EIF4EBP3 TUT4 TUT4 NT5C3B NT5C3B DIS3L2 DIS3L2 ENSCANP00000026065 ENSCANP00000026065 GZMB GZMB EXOSC3 EXOSC3 NCL NCL IGFBP5 IGFBP5 CIRBP CIRBP LOC105518744 LOC105518744 GIGYF2 GIGYF2 TRIM71 TRIM71 LOC105521132 LOC105521132 LARP1 LARP1 EXOSC9 EXOSC9 EIF4E EIF4E WT1 WT1 XRN1 XRN1 SESN2 SESN2 CPEB4 CPEB4 CNOT2 CNOT2 CNOT11 CNOT11 PDE12 PDE12 ENSCANP00000030698 ENSCANP00000030698 ZFP36L2 ZFP36L2 FXR2 FXR2 PATL1 PATL1 CALR CALR ENSCANP00000031207 ENSCANP00000031207 ATF4 ATF4 EXOSC5 EXOSC5 PABPN1L PABPN1L MOV10 MOV10 PCIF1 PCIF1 METTL3 METTL3 ENSCANP00000032068 ENSCANP00000032068 EXOSC2 EXOSC2 ROCK2 ROCK2 AGO1 AGO1 EIF4E2 EIF4E2 DHX36 DHX36 EXOSC8 EXOSC8 CPEB3 CPEB3 METTL14 METTL14 DND1 DND1 MARF1 MARF1 CPEB2 CPEB2 RPL13A RPL13A GRB7 GRB7 PAIP2 PAIP2 CNOT1 CNOT1 DAPK1 DAPK1 TNRC6A TNRC6A LOC105501854 LOC105501854 EIF2AK4 EIF2AK4 PUS7 PUS7 MRPL13 MRPL13 TNRC6C TNRC6C EXOSC7 EXOSC7 PAIP2B PAIP2B ZC3H12A ZC3H12A TYMS TYMS TPR TPR DDX6 DDX6 PUM1 PUM1 PNLDC1 PNLDC1 RC3H2 RC3H2 CNOT7 CNOT7 EIF4A3 EIF4A3 CNOT8 CNOT8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLR2DRNA polymerase II subunit D. (142 aa)
ENSCANP00000000135Uncharacterized protein; Belongs to the universal ribosomal protein uL13 family. (203 aa)
DCP1ADecapping mRNA 1A. (582 aa)
DAPK3Death associated protein kinase 3; Belongs to the protein kinase superfamily. (454 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (434 aa)
DIS3DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease; Belongs to the RNR ribonuclease family. (958 aa)
MLH1MutL homolog 1. (743 aa)
ZFP36ZFP36 ring finger protein. (332 aa)
NANOS2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
LOC105526708Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. (86 aa)
ZNF540Zinc finger protein 540. (660 aa)
PATL2PAT1 homolog 2. (538 aa)
ILF3Interleukin enhancer binding factor 3. (898 aa)
CNOT3CCR4-NOT transcription complex subunit 3. (751 aa)
LOC105523217Uncharacterized protein. (458 aa)
ENSCANP00000004241SHMT domain-containing protein. (396 aa)
LRRC27Leucine rich repeat containing 27. (529 aa)
KHSRPKH-type splicing regulatory protein. (631 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (587 aa)
PLEKHN1Pleckstrin homology domain containing N1. (615 aa)
TSC1TSC complex subunit 1. (1164 aa)
SAMD4BSterile alpha motif domain containing 4B. (694 aa)
AGO4Protein argonaute-4; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (855 aa)
ENSCANP00000005215Uncharacterized protein. (118 aa)
HNRNPDHeterogeneous nuclear ribonucleoprotein D. (355 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1187 aa)
ENSCANP00000005498Uncharacterized protein. (165 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
ENSCANP00000005698Uncharacterized protein. (136 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (110 aa)
RBM4BRNA binding motif protein 4B. (359 aa)
ENC1Ectodermal-neural cortex 1. (589 aa)
EPRS1Glutamyl-prolyl-tRNA synthetase. (1521 aa)
PMLPromyelocytic leukemia. (882 aa)
SYNCRIPSynaptotagmin binding cytoplasmic RNA interacting protein. (562 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (557 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
FTOFTO_NTD domain-containing protein. (505 aa)
ENSCANP00000008732CSP domain-containing protein. (296 aa)
ENSCANP00000009029Uncharacterized protein. (141 aa)
ENSCANP00000009286Uncharacterized protein. (71 aa)
LOC105508378Uncharacterized protein. (691 aa)
CNOT6LCCR4-NOT transcription complex subunit 6 like. (559 aa)
ZC3H12DZinc finger CCCH-type containing 12D. (526 aa)
LSM14AUncharacterized protein. (471 aa)
RIDAUncharacterized protein. (137 aa)
PARNPoly(A)-specific ribonuclease. (620 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (561 aa)
FXR1FMR1 autosomal homolog 1. (648 aa)
ENSCANP00000011836Uncharacterized protein. (288 aa)
CNOT4CCR4-NOT transcription complex subunit 4. (713 aa)
C8orf88Chromosome 8 open reading frame 88. (117 aa)
IREB2Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (964 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (973 aa)
ENSCANP00000012626Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (109 aa)
LIN28ALin-28 homolog A. (209 aa)
UPF1UPF1 RNA helicase and ATPase. (1079 aa)
RBM24RNA binding motif protein 24. (252 aa)
DCP2Decapping mRNA 2. (420 aa)
ENSCANP00000013869Thymidylat_synt domain-containing protein. (134 aa)
SRP9Signal recognition particle 9 kDa protein; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. (86 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1832 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (552 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (875 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1368 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (721 aa)
MALSU1Mitochondrial assembly of ribosomal large subunit 1. (235 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
TIA1TIA1 cytotoxic granule associated RNA binding protein. (386 aa)
ENSCANP00000016366Uncharacterized protein. (127 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase. (335 aa)
RARARetinoic acid receptor alpha. (478 aa)
CPEB1Cytoplasmic polyadenylation element binding protein 1. (613 aa)
LOC105507012ANK_REP_REGION domain-containing protein. (595 aa)
DCPSDecapping enzyme, scavenger. (339 aa)
NOCTEndo/exonuclease/phosphatase domain-containing protein. (431 aa)
ENSCANP00000017238CSD_1 domain-containing protein. (323 aa)
ENSCANP00000017240Uncharacterized protein. (91 aa)
RC3H1Ring finger and CCCH-type domains 1. (1134 aa)
LOC105514134Uncharacterized protein. (457 aa)
ENSCANP00000017887Uncharacterized protein. (146 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (588 aa)
CAPRIN1Cell cycle associated protein 1. (717 aa)
LOC105512634Uncharacterized protein. (231 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
ENSCANP00000019087Uncharacterized protein. (298 aa)
BANK1B cell scaffold protein with ankyrin repeats 1. (786 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (855 aa)
AGO3Protein argonaute-3; Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. (860 aa)
SHFLShiftless antiviral inhibitor of ribosomal frameshifting. (291 aa)
UNKUnk zinc finger. (810 aa)
EIF4G1Eukaryotic translation initiation factor 4 gamma 1. (1599 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (783 aa)
BTG2BTG anti-proliferation factor 2. (158 aa)
FMR1Fragile X mental retardation 1. (632 aa)
PRG3Proteoglycan 3, pro eosinophil major basic protein 2. (225 aa)
SAMD4ASterile alpha motif domain containing 4A. (718 aa)
NANOS3Nanos C2HC-type zinc finger 3; Belongs to the nanos family. (191 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (965 aa)
CAPRIN2Caprin family member 2. (1068 aa)
METTL16U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; RNA N6-methyltransferase that methylates adenosine residues of a subset of RNAs and plays a key role in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6- methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. In presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifical [...] (519 aa)
YBX1CSD_1 domain-containing protein. (275 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
EIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2. (71 aa)
TUT7Terminal uridylyl transferase 7. (1490 aa)
RNF139Ring finger protein 139. (664 aa)
DCP1BDecapping mRNA 1B. (616 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (259 aa)
RGS2Regulator of G protein signaling 2. (211 aa)
IGF2BP3Insulin like growth factor 2 mRNA binding protein 3. (579 aa)
EIF4EBP3Eukaryotic translation initiation factor 4E binding protein 3. (99 aa)
TUT4Terminal uridylyl transferase 4. (1649 aa)
NT5C3B5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa)
DIS3L2DIS3 like 3'-5' exoribonuclease 2; Belongs to the RNR ribonuclease family. (831 aa)
ENSCANP00000026065Uncharacterized protein. (76 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (247 aa)
EXOSC3Exosome component 3. (275 aa)
NCLNucleolin. (418 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
CIRBPCold inducible RNA binding protein. (287 aa)
LOC105518744Uncharacterized protein. (188 aa)
GIGYF2GRB10 interacting GYF protein 2. (1303 aa)
TRIM71Tripartite motif containing 71. (654 aa)
LOC105521132FTO_NTD domain-containing protein. (533 aa)
LARP1La ribonucleoprotein domain family member 1. (1021 aa)
EXOSC9Exosome component 9. (456 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
WT1WT1 transcription factor. (517 aa)
XRN15'-3' exoribonuclease 1. (1706 aa)
SESN2Sestrin 2. (479 aa)
CPEB4Cytoplasmic polyadenylation element binding protein 4. (729 aa)
CNOT2CCR4-NOT transcription complex subunit 2. (540 aa)
CNOT11CCR4-NOT transcription complex subunit 11. (451 aa)
PDE12Phosphodiesterase 12. (609 aa)
ENSCANP00000030698Endo/exonuclease/phosphatase domain-containing protein. (355 aa)
ZFP36L2ZFP36 ring finger protein like 2. (299 aa)
FXR2FMR1 autosomal homolog 2. (673 aa)
PATL1PAT1 homolog 1, processing body mRNA decay factor. (770 aa)
CALRCalreticulin. (417 aa)
ENSCANP00000031207Uncharacterized protein. (457 aa)
ATF4Activating transcription factor 4. (351 aa)
EXOSC5Exosome component 5. (235 aa)
PABPN1LPoly(A) binding protein nuclear 1 like, cytoplasmic. (276 aa)
MOV10Mov10 RISC complex RNA helicase. (1003 aa)
PCIF1PDX1 C-terminal inhibiting factor 1. (704 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
ENSCANP00000032068Uncharacterized protein. (186 aa)
EXOSC2Uncharacterized protein. (293 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1383 aa)
AGO1Argonaute RISC component 1; Belongs to the argonaute family. (857 aa)
EIF4E2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (249 aa)
DHX36DEAH-box helicase 36. (1008 aa)
EXOSC8Exosome component 8. (276 aa)
CPEB3Cytoplasmic polyadenylation element binding protein 3. (718 aa)
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (456 aa)
DND1DND microRNA-mediated repression inhibitor 1. (199 aa)
MARF1Meiosis regulator and mRNA stability factor 1. (1742 aa)
CPEB2Cytoplasmic polyadenylation element binding protein 2. (647 aa)
RPL13AUncharacterized protein; Belongs to the universal ribosomal protein uL13 family. (203 aa)
GRB7Growth factor receptor bound protein 7. (558 aa)
PAIP2Poly(A) binding protein interacting protein 2. (124 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2382 aa)
DAPK1Death associated protein kinase 1. (1430 aa)
TNRC6ATrinucleotide repeat containing adaptor 6A. (1958 aa)
LOC105501854Ribosomal_S3_C domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (252 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1633 aa)
PUS7Pseudouridine synthase 7. (662 aa)
MRPL13Mitochondrial ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family. (178 aa)
TNRC6CTrinucleotide repeat containing adaptor 6C. (1940 aa)
EXOSC7Exosome component 7. (291 aa)
PAIP2BPoly(A) binding protein interacting protein 2B. (123 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (601 aa)
TYMSThymidylate synthetase. (313 aa)
TPRTranslocated promoter region, nuclear basket protein. (2363 aa)
DDX6DEAD-box helicase 6; Belongs to the DEAD box helicase family. (434 aa)
PUM1Pumilio RNA binding family member 1. (1224 aa)
PNLDC1PARN like, ribonuclease domain containing 1. (520 aa)
RC3H2Ring finger and CCCH-type domains 2. (1191 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
EIF4A3Eukaryotic translation initiation factor 4A3. (362 aa)
CNOT8CCR4-NOT transcription complex subunit 8. (292 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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