30 items (Colobus angolensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PAX6	Paired box 6. (478 aa)
	FOXA1	Forkhead box A1. (447 aa)
	TMEM107	Transmembrane protein 107. (146 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (768 aa)
	WDR19	WD repeat domain 19. (1342 aa)
	GSC	Goosecoid homeobox. (145 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	TULP3	TUB like protein 3; Belongs to the TUB family. (453 aa)
	PTCH1	Patched 1. (1449 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	RPGRIP1L	RPGRIP1 like. (1313 aa)
	SUFU	Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (519 aa)
	GLI3	GLI family zinc finger 3. (1580 aa)
	KDM2B	Lysine demethylase 2B. (1336 aa)
	SSBP3	Single stranded DNA binding protein 3. (369 aa)
	ENSCANP00000018739	Uncharacterized protein. (291 aa)
	RNF220	Ring finger protein 220. (566 aa)
	FKBP8	Peptidylprolyl isomerase. (421 aa)
	ARL13B	ADP ribosylation factor like GTPase 13B. (428 aa)
	TCTN1	Tectonic family member 1. (587 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
	ATP6AP2	ATPase H+ transporting accessory protein 2. (345 aa)
	IFT140	Intraflagellar transport 140. (1470 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	SHH	Sonic hedgehog signaling molecule. (390 aa)
	DZIP1L	DAZ interacting zinc finger protein 1 like. (766 aa)
	TBC1D32	TBC1 domain family member 32. (1261 aa)
	SOX17	SRY-box transcription factor 17. (412 aa)
	ENSCANP00000036443	TPR_REGION domain-containing protein. (356 aa)

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARL13B	GLI3	ENSCANP00000021940	ENSCANP00000015504	ADP ribosylation factor like GTPase 13B.	GLI family zinc finger 3.	0.559
ARL13B	IFT140	ENSCANP00000021940	ENSCANP00000027534	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 140.	0.403
ARL13B	RPGRIP1L	ENSCANP00000021940	ENSCANP00000014625	ADP ribosylation factor like GTPase 13B.	RPGRIP1 like.	0.557
ARL13B	SMO	ENSCANP00000021940	ENSCANP00000006132	ADP ribosylation factor like GTPase 13B.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.538
ARL13B	TCTN1	ENSCANP00000021940	ENSCANP00000024810	ADP ribosylation factor like GTPase 13B.	Tectonic family member 1.	0.422
ARL13B	TULP3	ENSCANP00000021940	ENSCANP00000010928	ADP ribosylation factor like GTPase 13B.	TUB like protein 3; Belongs to the TUB family.	0.545
BMP4	FGF8	ENSCANP00000013712	ENSCANP00000009026	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.507
BMP4	SHH	ENSCANP00000013712	ENSCANP00000030559	Bone morphogenetic protein 4.	Sonic hedgehog signaling molecule.	0.568
BMP4	WNT3A	ENSCANP00000013712	ENSCANP00000028381	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.454
FGF8	BMP4	ENSCANP00000009026	ENSCANP00000013712	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.507
FGF8	GLI3	ENSCANP00000009026	ENSCANP00000015504	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	GLI family zinc finger 3.	0.422
FGF8	PAX6	ENSCANP00000009026	ENSCANP00000028102	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Paired box 6.	0.488
FGF8	SHH	ENSCANP00000009026	ENSCANP00000030559	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Sonic hedgehog signaling molecule.	0.577
FGF8	SMO	ENSCANP00000009026	ENSCANP00000006132	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.402
FGF8	WNT1	ENSCANP00000009026	ENSCANP00000009219	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.547
FOXA1	SHH	ENSCANP00000003005	ENSCANP00000030559	Forkhead box A1.	Sonic hedgehog signaling molecule.	0.588
FOXA1	SOX17	ENSCANP00000003005	ENSCANP00000036195	Forkhead box A1.	SRY-box transcription factor 17.	0.412
GLI3	ARL13B	ENSCANP00000015504	ENSCANP00000021940	GLI family zinc finger 3.	ADP ribosylation factor like GTPase 13B.	0.559
GLI3	FGF8	ENSCANP00000015504	ENSCANP00000009026	GLI family zinc finger 3.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.422
GLI3	PAX6	ENSCANP00000015504	ENSCANP00000028102	GLI family zinc finger 3.	Paired box 6.	0.405