STRINGSTRING
FGF8 FGF8 LRRC1 LRRC1 SRC SRC PLXND1 PLXND1 BSX BSX FRS2 FRS2 RARG RARG LRP5 LRP5 AREG AREG IL6 IL6 SERPINB5 SERPINB5 TGM2 TGM2 NRG3 NRG3 TP63 TP63 CUL3 CUL3 ESRP2 ESRP2 ESR1 ESR1 NRP1 NRP1 PLAG1 PLAG1 SOX9 SOX9 EPHA2 EPHA2 NFIB NFIB WNT5A WNT5A TNC TNC TGFB3 TGFB3 MST1 MST1 FGF7 FGF7 SHH SHH CSMD1 CSMD1 PROX1 PROX1 ELF3 ELF3 PAX6 PAX6 CYP7B1 CYP7B1 NOTCH1 NOTCH1 IGFBP5 IGFBP5 WNT4 WNT4 NTN1 NTN1 ARG1 ARG1 HOXB13 HOXB13 NFKB1 NFKB1 BMP7 BMP7 EDAR EDAR TGFB2 TGFB2 SEMA3C SEMA3C TWSG1 TWSG1 NKX2-3 NKX2-3 DAG1 DAG1 STAT6 STAT6 FGFR2 FGFR2 SELENOH SELENOH CSF1R CSF1R EDA EDA HOXD13 HOXD13 GLI3 GLI3 RPS6KA1 RPS6KA1 CSMD2 CSMD2 TBX3 TBX3 BMP4 BMP4 GDF7 GDF7 FGL1 FGL1 HOXA13 HOXA13 CSF1 CSF1 AR AR LAMA5 LAMA5 PTCH1 PTCH1 BTRC BTRC KDM5B KDM5B MSN MSN POLB POLB LAMA1 LAMA1 NKX3-1 NKX3-1 PLXNA1 PLXNA1 CAV1 CAV1 TGFB1 TGFB1 NOTCH2 NOTCH2 FGF10 FGF10 ENSCANP00000008115 ENSCANP00000008115 PML PML MKI67 MKI67 SOSTDC1 SOSTDC1 TGFA TGFA TBX2 TBX2 BCL2 BCL2 TGFBR2 TGFBR2 NOG NOG VDR VDR FOXA1 FOXA1 FEM1B FEM1B SCRIB SCRIB DDR1 DDR1 MED1 MED1 SFRP1 SFRP1 DUOX2 DUOX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
LRRC1Leucine rich repeat containing 1. (524 aa)
SRCTyrosine-protein kinase. (458 aa)
PLXND1Plexin D1. (1736 aa)
BSXBrain specific homeobox. (232 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
RARGRetinoic acid receptor gamma. (461 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
AREGAmphiregulin. (275 aa)
IL6Interleukin 6. (214 aa)
SERPINB5Serpin family B member 5; Belongs to the serpin family. (327 aa)
TGM2Transglutaminase 2. (687 aa)
NRG3Neuregulin 3. (627 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (654 aa)
CUL3Cullin 3; Belongs to the cullin family. (775 aa)
ESRP2Epithelial splicing regulatory protein 2. (720 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
PLAG1PLAG1 zinc finger. (500 aa)
SOX9SRY-box transcription factor 9. (509 aa)
EPHA2EPH receptor A2. (976 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (570 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TNCTenascin C. (2201 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
SHHSonic hedgehog signaling molecule. (390 aa)
CSMD1CUB and Sushi multiple domains 1. (3565 aa)
PROX1Prospero homeobox 1. (737 aa)
ELF3E74 like ETS transcription factor 3. (383 aa)
PAX6Paired box 6. (478 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
NOTCH1Notch receptor 1. (2559 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
NTN1Netrin 1. (576 aa)
ARG1Arginase. (322 aa)
HOXB13Homeobox B13. (284 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
EDAREctodysplasin A receptor. (480 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (750 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
NKX2-3NK2 homeobox 3. (240 aa)
DAG1Dystroglycan 1. (894 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
SELENOHSelenoprotein H. (121 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (974 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
HOXD13Homeobox D13. (303 aa)
GLI3GLI family zinc finger 3. (1580 aa)
RPS6KA1Ribosomal protein S6 kinase. (728 aa)
CSMD2CUB and Sushi multiple domains 2. (3537 aa)
TBX3T-box transcription factor 3. (743 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GDF7Growth differentiation factor 7. (366 aa)
FGL1Fibrinogen like 1. (312 aa)
HOXA13Homeobox A13. (244 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (551 aa)
ARAndrogen receptor. (897 aa)
LAMA5Laminin subunit alpha 5. (3457 aa)
PTCH1Patched 1. (1449 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (527 aa)
KDM5BLysine demethylase 5B. (1487 aa)
MSNMoesin. (577 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (310 aa)
LAMA1Laminin subunit alpha 1. (3054 aa)
NKX3-1NK3 homeobox 1. (232 aa)
PLXNA1Plexin A1. (1906 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (179 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
NOTCH2Notch receptor 2. (2471 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSCANP00000008115LIM zinc-binding domain-containing protein. (63 aa)
PMLPromyelocytic leukemia. (882 aa)
MKI67Marker of proliferation Ki-67. (3249 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
TGFATransforming growth factor alpha. (166 aa)
TBX2T-box transcription factor 2. (590 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
VDRVitamin D receptor. (477 aa)
FOXA1Forkhead box A1. (447 aa)
FEM1BFem-1 homolog B. (627 aa)
SCRIBScribble planar cell polarity protein. (1662 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (894 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1576 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
DUOX2Dual oxidase 2. (1481 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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