STRINGSTRING
EXT1 EXT1 SFRP1 SFRP1 LEF1 LEF1 SMAD3 SMAD3 MEGF8 MEGF8 ENG ENG NOG NOG ATF2 ATF2 LOC105521177 LOC105521177 COMP COMP TMEM100 TMEM100 DSG4 DSG4 ACVR2A ACVR2A SMAD7 SMAD7 SOSTDC1 SOSTDC1 FST FST SPART SPART SOST SOST BMP5 BMP5 BMPR1B BMPR1B NOTCH2 NOTCH2 TGFB1 TGFB1 BMP6 BMP6 PDCD4 PDCD4 ZNF8 ZNF8 SMAD9 SMAD9 CHRDL1 CHRDL1 ACVRL1 ACVRL1 CHRD CHRD USP9X USP9X RGMA RGMA TMPRSS6 TMPRSS6 ENSCANP00000012853 ENSCANP00000012853 ACVR1 ACVR1 BMP2 BMP2 BMPR1A BMPR1A GDF7 GDF7 BMP4 BMP4 GDF6 GDF6 USP15 USP15 HFE HFE BMPER BMPER TGFBR3 TGFBR3 MAPK3 MAPK3 GDF2 GDF2 SMAD5 SMAD5 BMP15 BMP15 SFRP2 SFRP2 SMAD1 SMAD1 ETV2 ETV2 TWSG1 TWSG1 RGMB RGMB DLX5 DLX5 SLC33A1 SLC33A1 TGFB2 TGFB2 RUNX2 RUNX2 FKBP8 FKBP8 ZNF831 ZNF831 BMP7 BMP7 FAM83G FAM83G GDF5 GDF5 ACVR2B ACVR2B LOC105516701 LOC105516701 ZCCHC12 ZCCHC12 SMURF1 SMURF1 BMP10 BMP10 SMAD4 SMAD4 DDX5 DDX5 BMP8B BMP8B HIVEP1 HIVEP1 GDF3 GDF3 TGFB3 TGFB3 BMPR2 BMPR2 HJV HJV MSX1 MSX1 WNT5A WNT5A ABL1 ABL1 LOC105516700 LOC105516700 NODAL NODAL EGR1 EGR1 SMPD3 SMPD3 ENSCANP00000036443 ENSCANP00000036443 SLC39A5 SLC39A5 CCDC142 CCDC142 DLX3 DLX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MEGF8Multiple EGF like domains 8. (2837 aa)
ENGEndoglin. (658 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
LOC105521177TGF_BETA_2 domain-containing protein. (238 aa)
COMPCartilage oligomeric matrix protein. (757 aa)
TMEM100Transmembrane protein 100. (134 aa)
DSG4Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1052 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
FSTFollistatin. (317 aa)
SPARTSpartin. (666 aa)
SOSTSclerostin. (213 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NOTCH2Notch receptor 2. (2471 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
BMP6Bone morphogenetic protein 6. (331 aa)
PDCD4Programmed cell death 4. (470 aa)
ZNF8Zinc finger protein 8. (575 aa)
SMAD9Mothers against decapentaplegic homolog. (467 aa)
CHRDL1Chordin like 1. (458 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
CHRDChordin. (871 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2418 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (458 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (809 aa)
ENSCANP00000012853C2 domain-containing protein. (51 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
GDF7Growth differentiation factor 7. (366 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GDF6Growth differentiation factor 6. (455 aa)
USP15Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (981 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
BMPERBMP binding endothelial regulator. (685 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
GDF2Growth differentiation factor 2. (429 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
BMP15Bone morphogenetic protein 15. (393 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
ETV2ETS domain-containing protein. (155 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (401 aa)
DLX5Distal-less homeobox 5. (289 aa)
SLC33A1Solute carrier family 33 member 1. (550 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
RUNX2RUNX family transcription factor 2. (475 aa)
FKBP8Peptidylprolyl isomerase. (421 aa)
ZNF831Zinc finger protein 831. (1668 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
FAM83GFamily with sequence similarity 83 member G. (823 aa)
GDF5Growth differentiation factor 5. (499 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (750 aa)
LOC105516701TGF_BETA_2 domain-containing protein. (283 aa)
ZCCHC12Zinc finger CCHC-type containing 12. (402 aa)
SMURF1E3 ubiquitin-protein ligase. (763 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
BMP8BTGF_BETA_2 domain-containing protein. (336 aa)
HIVEP1Human immunodeficiency virus type I enhancer binding protein 1. (2719 aa)
GDF3Growth differentiation factor 3. (364 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
BMPR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1030 aa)
HJVHemojuvelin BMP co-receptor. (425 aa)
MSX1Msh homeobox 1. (199 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
LOC105516700TGF_BETA_2 domain-containing protein. (311 aa)
NODALNodal growth differentiation factor. (347 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (527 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
ENSCANP00000036443TPR_REGION domain-containing protein. (356 aa)
SLC39A5Solute carrier family 39 member 5. (540 aa)
CCDC142Coiled-coil domain containing 142. (750 aa)
DLX3Distal-less homeobox 3. (287 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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