(60 nodes) Pancreas development network (Colobus angolensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCDC39	Coiled-coil domain containing 39. (942 aa)
	CCDC40	Coiled-coil domain containing 40. (1135 aa)
	FOXF1	Forkhead box F1. (351 aa)
	ISL1	ISL LIM homeobox 1. (349 aa)
	MEIS2	Meis homeobox 2. (477 aa)
	PAX4	Paired box 4. (351 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	ONECUT2	One cut domain family member. (418 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	NKX3-2	NK3 homeobox 2. (284 aa)
	IL6R	Interleukin 6 receptor. (568 aa)
	SHH	Sonic hedgehog signaling molecule. (390 aa)
	RFX6	Regulatory factor X6. (928 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	CDH2	Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (890 aa)
	BHLHA15	Basic helix-loop-helix family member a15. (194 aa)
	PAX6	Paired box 6. (478 aa)
	ACVR2B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (750 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (723 aa)
	NKX2-2	NK2 homeobox 2. (273 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2 alpha kinase 3. (965 aa)
	HNF1A	HNF1 homeobox A. (662 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (406 aa)
	ILDR2	Immunoglobulin like domain containing receptor 2. (565 aa)
	BAK1	BCL2 antagonist/killer 1. (211 aa)
	GIP	GLUCAGON domain-containing protein. (79 aa)
	PTF1A	Pancreas associated transcription factor 1a. (178 aa)
	NR5A2	Nuclear receptor subfamily 5 group A member 2. (541 aa)
	TCF7L2	Transcription factor 7 like 2. (577 aa)
	SELENOT	Selenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (195 aa)
	MSLN	Mesothelin. (635 aa)
	ENSCANP00000016345	Homeobox domain-containing protein. (108 aa)
	GIPR	Gastric inhibitory polypeptide receptor; Belongs to the G-protein coupled receptor 2 family. (249 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (464 aa)
	PCSK1	Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (749 aa)
	SIDT2	SID1 transmembrane family member 2. (855 aa)
	CELA1	Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (257 aa)
	BMP6	Bone morphogenetic protein 6. (331 aa)
	PDX1	Pancreatic and duodenal homeobox 1. (283 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	HNF1B	HNF1 homeobox B. (558 aa)
	BMP5	Bone morphogenetic protein 5. (454 aa)
	RBM4B	RNA binding motif protein 4B. (359 aa)
	WFS1	Wolframin ER transmembrane glycoprotein. (890 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (768 aa)
	FOXA2	Forkhead box A2. (463 aa)
	GATA6	GATA binding protein 6. (462 aa)
	ZIC3	Zic family member 3. (466 aa)
	IGF2	Insulin like growth factor 2. (236 aa)
	NEUROD1	Neurogenic differentiation factor. (356 aa)
	GDF11	Growth differentiation factor 11. (345 aa)
	NKX6-1	NK6 homeobox 1. (366 aa)
	IHH	Indian hedgehog signaling molecule. (373 aa)
	MEN1	Menin 1. (610 aa)
	ALDH1A2	Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (524 aa)
	DNAAF1	Dynein assembly factor 1, axonemal. (692 aa)
	RFX3	Regulatory factor X3. (777 aa)

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVR2B	BMP4	ENSCANP00000027260	ENSCANP00000013712	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.970
ACVR2B	BMP5	ENSCANP00000027260	ENSCANP00000008018	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 5.	0.938
ACVR2B	BMP6	ENSCANP00000027260	ENSCANP00000009139	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 6.	0.956
ACVR2B	GDF11	ENSCANP00000027260	ENSCANP00000002818	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Growth differentiation factor 11.	0.992
ACVR2B	SMAD2	ENSCANP00000027260	ENSCANP00000036850	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.897
ACVR2B	ZIC3	ENSCANP00000027260	ENSCANP00000005092	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Zic family member 3.	0.559
BMP4	ACVR2B	ENSCANP00000013712	ENSCANP00000027260	Bone morphogenetic protein 4.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.970
BMP4	BMP5	ENSCANP00000013712	ENSCANP00000008018	Bone morphogenetic protein 4.	Bone morphogenetic protein 5.	0.632
BMP4	BMP6	ENSCANP00000013712	ENSCANP00000009139	Bone morphogenetic protein 4.	Bone morphogenetic protein 6.	0.897
BMP4	CTNNB1	ENSCANP00000013712	ENSCANP00000011681	Bone morphogenetic protein 4.	Catenin beta 1.	0.411
BMP4	FGF10	ENSCANP00000013712	ENSCANP00000008290	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.529
BMP4	FOXF1	ENSCANP00000013712	ENSCANP00000039479	Bone morphogenetic protein 4.	Forkhead box F1.	0.621
BMP4	SHH	ENSCANP00000013712	ENSCANP00000030559	Bone morphogenetic protein 4.	Sonic hedgehog signaling molecule.	0.568
BMP4	SMAD2	ENSCANP00000013712	ENSCANP00000036850	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.632
BMP5	ACVR2B	ENSCANP00000008018	ENSCANP00000027260	Bone morphogenetic protein 5.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.938
BMP5	BMP4	ENSCANP00000008018	ENSCANP00000013712	Bone morphogenetic protein 5.	Bone morphogenetic protein 4.	0.632
BMP6	ACVR2B	ENSCANP00000009139	ENSCANP00000027260	Bone morphogenetic protein 6.	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.956
BMP6	BMP4	ENSCANP00000009139	ENSCANP00000013712	Bone morphogenetic protein 6.	Bone morphogenetic protein 4.	0.897
CCDC39	CCDC40	ENSCANP00000036338	ENSCANP00000040282	Coiled-coil domain containing 39.	Coiled-coil domain containing 40.	0.693
CCDC39	DNAAF1	ENSCANP00000036338	ENSCANP00000000311	Coiled-coil domain containing 39.	Dynein assembly factor 1, axonemal.	0.553