79 items (Colobus angolensis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	STING1	Transmembrane protein 173. (379 aa)
	PRKN	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (465 aa)
	STK3	Serine/threonine kinase 3. (489 aa)
	BLK	Tyrosine-protein kinase. (505 aa)
	ARHGEF7	Rho guanine nucleotide exchange factor 7. (748 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (179 aa)
	IDE	Insulin degrading enzyme; Belongs to the peptidase M16 family. (1019 aa)
	LOC105510963	Serine/threonine-protein phosphatase. (291 aa)
	PIN1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	ENSCANP00000009431	Uncharacterized protein. (233 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1197 aa)
	ADD1	Adducin 1. (768 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (478 aa)
	TIAM1	T cell lymphoma invasion and metastasis 1. (1591 aa)
	POLDIP2	DNA polymerase delta interacting protein 2. (377 aa)
	TRIM21	Tripartite motif containing 21. (475 aa)
	ADD2	Adducin 2. (726 aa)
	ACE	Angiotensin-converting enzyme. (1223 aa)
	DACT1	Dishevelled binding antagonist of beta catenin 1. (751 aa)
	SPON1	Spondin 1. (806 aa)
	BMP2	Bone morphogenetic protein 2. (396 aa)
	SPAG8	Sperm associated antigen 8. (482 aa)
	BMP4	Bone morphogenetic protein 4. (408 aa)
	LFNG	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (304 aa)
	HFE	Homeostatic iron regulator; Belongs to the MHC class I family. (348 aa)
	EP300	E1A binding protein p300. (2409 aa)
	AKTIP	AKT interacting protein. (293 aa)
	BDNF	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (312 aa)
	TRIB3	Tribbles pseudokinase 3. (385 aa)
	TCF7L2	Transcription factor 7 like 2. (577 aa)
	MARK3	Non-specific serine/threonine protein kinase. (764 aa)
	AMFR	Autocrine motility factor receptor. (548 aa)
	TAF1	Transcription initiation factor TFIID subunit. (1926 aa)
	APOE	Apolipoprotein E. (189 aa)
	DERL1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
	LRP1	LDL receptor related protein 1. (4544 aa)
	PLXND1	Plexin D1. (1736 aa)
	MFNG	Beta-1,3-N-acetylglucosaminyltransferase. (321 aa)
	HSF1	Heat shock transcription factor 1. (521 aa)
	RFNG	RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (205 aa)
	DTX3L	Deltex E3 ubiquitin ligase 3L. (687 aa)
	PKD1	Polycystin 1, transient receptor potential channel interacting. (4053 aa)
	PLCL1	Phosphoinositide phospholipase C. (1034 aa)
	CTHRC1	Collagen triple helix repeat containing 1. (147 aa)
	MAPRE3	Microtubule associated protein RP/EB family member 3. (281 aa)
	KRIT1	Uncharacterized protein. (736 aa)
	NRP1	Neuropilin; Belongs to the neuropilin family. (923 aa)
	PLCL2	Phosphoinositide phospholipase C. (1059 aa)
	MMP9	Matrix metallopeptidase 9. (707 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	LRRK2	Leucine rich repeat kinase 2. (2527 aa)
	SPTA1	Spectrin alpha, erythrocytic 1. (2420 aa)
	ANXA2	Annexin. (357 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (302 aa)
	ENSCANP00000020706	Protein kinase domain-containing protein. (281 aa)
	SPPL3	Signal peptide peptidase like 3. (384 aa)
	TERT	Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1059 aa)
	NVL	Nuclear VCP like. (838 aa)
	ENSCANP00000023654	Uncharacterized protein. (281 aa)
	CAPRIN2	Caprin family member 2. (1068 aa)
	RAPGEF2	Rap guanine nucleotide exchange factor 2. (1499 aa)
	EPB41	Erythrocyte membrane protein band 4.1. (774 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (463 aa)
	EPHB6	EPH receptor B6. (1019 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (275 aa)
	TICAM1	Toll like receptor adaptor molecule 1. (517 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	HIP1R	Huntingtin interacting protein 1 related. (1062 aa)
	ZNF268	Zinc finger protein 268. (947 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (275 aa)
	WNT5A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
	APP	Amyloid beta precursor protein. (770 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (540 aa)
	CSF3	Colony stimulating factor 3. (207 aa)
	EPB41L5	Erythrocyte membrane protein band 4.1 like 5. (671 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (119 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (372 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	MEN1	Menin 1. (610 aa)

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	CDK5	ENSCANP00000033386	ENSCANP00000020238	Tyrosine-protein kinase.	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	0.440
ABL1	ENSCANP00000020706	ENSCANP00000033386	ENSCANP00000020706	Tyrosine-protein kinase.	Protein kinase domain-containing protein.	0.440
ABL1	EP300	ENSCANP00000033386	ENSCANP00000014363	Tyrosine-protein kinase.	E1A binding protein p300.	0.459
ABL1	EPHB6	ENSCANP00000033386	ENSCANP00000027718	Tyrosine-protein kinase.	EPH receptor B6.	0.822
ACE	ADD1	ENSCANP00000011988	ENSCANP00000010680	Angiotensin-converting enzyme.	Adducin 1.	0.412
ACE	APOE	ENSCANP00000011988	ENSCANP00000019437	Angiotensin-converting enzyme.	Apolipoprotein E.	0.524
ADD1	ACE	ENSCANP00000010680	ENSCANP00000011988	Adducin 1.	Angiotensin-converting enzyme.	0.412
ADD1	ADD2	ENSCANP00000010680	ENSCANP00000011838	Adducin 1.	Adducin 2.	0.949
ADD1	EPB41	ENSCANP00000010680	ENSCANP00000025816	Adducin 1.	Erythrocyte membrane protein band 4.1.	0.662
ADD2	ADD1	ENSCANP00000011838	ENSCANP00000010680	Adducin 2.	Adducin 1.	0.949
ADD2	EPB41	ENSCANP00000011838	ENSCANP00000025816	Adducin 2.	Erythrocyte membrane protein band 4.1.	0.662
AMFR	DERL1	ENSCANP00000018120	ENSCANP00000019535	Autocrine motility factor receptor.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.985
ANXA2	APP	ENSCANP00000020214	ENSCANP00000031970	Annexin.	Amyloid beta precursor protein.	0.410
ANXA2	CAV1	ENSCANP00000020214	ENSCANP00000008835	Annexin.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.433
APOE	ACE	ENSCANP00000019437	ENSCANP00000011988	Apolipoprotein E.	Angiotensin-converting enzyme.	0.524
APOE	APP	ENSCANP00000019437	ENSCANP00000031970	Apolipoprotein E.	Amyloid beta precursor protein.	0.928
APOE	BDNF	ENSCANP00000019437	ENSCANP00000016073	Apolipoprotein E.	Brain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.	0.480
APOE	CAV1	ENSCANP00000019437	ENSCANP00000008835	Apolipoprotein E.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.400
APOE	LRP1	ENSCANP00000019437	ENSCANP00000039812	Apolipoprotein E.	LDL receptor related protein 1.	0.966
APOE	MMP9	ENSCANP00000019437	ENSCANP00000033457	Apolipoprotein E.	Matrix metallopeptidase 9.	0.570