STRINGSTRING
WAC WAC RNF8 RNF8 LEO1 LEO1 UBE2E1 UBE2E1 CTR9 CTR9 RNF40 RNF40 RNF20 RNF20 DTX3L DTX3L CDC73 CDC73
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WACWW domain containing adaptor with coiled-coil. (633 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (486 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (666 aa)
UBE2E1Ubiquitin conjugating enzyme E2 E1; Belongs to the ubiquitin-conjugating enzyme family. (193 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
RNF40E3 ubiquitin protein ligase; Belongs to the BRE1 family. (1001 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (687 aa)
CDC73Cell division cycle 73. (531 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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