STRINGSTRING
SESN3 SESN3 BMT2 BMT2 SESN2 SESN2 MAPK1 MAPK1 ATF3 ATF3 WDR24 WDR24 RNF152 RNF152 GCN1 GCN1 MAP3K5 MAP3K5 MAPK3 MAPK3 MAP1LC3A MAP1LC3A IMPACT IMPACT PRKD1 PRKD1 RRAGC RRAGC SEH1L SEH1L EIF2S1 EIF2S1 NPRL3 NPRL3 RRAGB RRAGB ATF2 ATF2 DAP DAP ENSCANP00000024844 ENSCANP00000024844 CDKN1A CDKN1A ITFG2 ITFG2 SZT2 SZT2 LOC105501014 LOC105501014 KPTN KPTN RRAGD RRAGD DAPL1 DAPL1 SESN1 SESN1 EIF2AK3 EIF2AK3 RNF167 RNF167 MTOR MTOR C12orf66 C12orf66 MAPK8 MAPK8 MAPK10 MAPK10 MIOS MIOS ATF4 ATF4 RRAGA RRAGA EIF2AK4 EIF2AK4 NPRL2 NPRL2 TFEB TFEB FLCN FLCN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SESN3Sestrin 3. (522 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
SESN2Sestrin 2. (479 aa)
MAPK1Mitogen-activated protein kinase. (343 aa)
ATF3Activating transcription factor 3. (181 aa)
WDR24WD repeat domain 24. (857 aa)
RNF152Ring finger protein 152. (203 aa)
GCN1GCN1 activator of EIF2AK4. (2366 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1364 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (125 aa)
IMPACTImpact RWD domain protein. (320 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
RRAGCRas related GTP binding C. (320 aa)
SEH1LSEH1 like nucleoporin; Belongs to the WD repeat SEC13 family. (337 aa)
EIF2S1Eukaryotic translation initiation factor 2 subunit alpha. (315 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (582 aa)
RRAGBRas related GTP binding B. (374 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
DAPUncharacterized protein. (83 aa)
ENSCANP00000024844Uncharacterized protein. (182 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
ITFG2Integrin alpha FG-GAP repeat containing 2. (447 aa)
SZT2SZT2 subunit of KICSTOR complex. (3431 aa)
LOC105501014Uncharacterized protein. (280 aa)
KPTNKaptin, actin binding protein. (436 aa)
RRAGDRas related GTP binding D. (400 aa)
DAPL1Death associated protein like 1. (107 aa)
SESN1Sestrin 1. (551 aa)
EIF2AK3Eukaryotic translation initiation factor 2 alpha kinase 3. (965 aa)
RNF167Ring finger protein 167. (351 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
C12orf66Chromosome 12 open reading frame 66. (495 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
MAPK10Mitogen-activated protein kinase. (550 aa)
MIOSMeiosis regulator for oocyte development. (800 aa)
ATF4Activating transcription factor 4. (351 aa)
RRAGARas related GTP binding A. (313 aa)
EIF2AK4Eukaryotic translation initiation factor 2 alpha kinase 4. (1633 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
TFEBTranscription factor EB. (490 aa)
FLCNFolliculin. (579 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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