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FAM20A FAM20A FAM20C FAM20C LEF1 LEF1 ROGDI ROGDI LHX8 LHX8 CCDC154 CCDC154 LOC105527037 LOC105527037 ENSCANP00000003738 ENSCANP00000003738 ATF2 ATF2 ODAM ODAM NF2 NF2 GATA6 GATA6 ACVR2A ACVR2A DLX1 DLX1 SMO SMO SOSTDC1 SOSTDC1 FST FST FGF10 FGF10 AMELX AMELX TGFB1 TGFB1 RELT RELT DSPP DSPP PERP PERP BCL2L11 BCL2L11 ITGB6 ITGB6 CTNNB1 CTNNB1 LAMA5 LAMA5 LOC105516286 LOC105516286 WDR72 WDR72 KLK4 KLK4 BMP2 BMP2 BMPR1A BMPR1A BMP4 BMP4 GLI3 GLI3 JAG2 JAG2 EDA EDA TCIRG1 TCIRG1 DLX3 DLX3 GLI2 GLI2 ENSCANP00000038657 ENSCANP00000038657 NECTIN1 NECTIN1 TP63 TP63 SMPD3 SMPD3 DLX2 DLX2 CTNNA1 CTNNA1 SCN5A SCN5A MSX1 MSX1 LRP4 LRP4 HTRA1 HTRA1 SHH SHH HDAC1 HDAC1 SERPINE1 SERPINE1 CNNM4 CNNM4 BAX BAX ACVR2B ACVR2B HAND2 HAND2 ENAM ENAM HAND1 HAND1 PPARA PPARA MMP20 MMP20 ADM ADM HDAC2 HDAC2 LOC105527362 LOC105527362 AMBN AMBN ANKRD11 ANKRD11 BSG BSG BMP7 BMP7 EDAR EDAR ENSCANP00000021244 ENSCANP00000021244 RUNX2 RUNX2 SLC24A4 SLC24A4 WNT6 WNT6 SCN10A SCN10A SLC34A1 SLC34A1 CFTR CFTR NKX2-3 NKX2-3 STIM1 STIM1 BCL11B BCL11B TRAF6 TRAF6 KLK5 KLK5 AMTN AMTN NGFR NGFR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FAM20AFAM20A golgi associated secretory pathway pseudokinase. (494 aa)
FAM20CFAM20C golgi associated secretory pathway kinase. (365 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
ROGDIRogdi atypical leucine zipper. (272 aa)
LHX8LIM homeobox 8. (377 aa)
CCDC154Coiled-coil domain containing 154. (549 aa)
LOC105527037Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (459 aa)
ENSCANP00000003738Uncharacterized protein. (247 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ODAMOdontogenic, ameloblast associated. (281 aa)
NF2Neurofibromin 2. (561 aa)
GATA6GATA binding protein 6. (462 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
DLX1Distal-less homeobox 1. (255 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (768 aa)
SOSTDC1Sclerostin domain containing 1. (230 aa)
FSTFollistatin. (317 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
AMELXAmelogenin X-linked. (205 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
RELTRELT TNF receptor. (430 aa)
DSPPDentin sialophosphoprotein. (1113 aa)
PERPP53 apoptosis effector related to PMP22. (193 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (198 aa)
ITGB6Integrin beta; Belongs to the integrin beta chain family. (746 aa)
CTNNB1Catenin beta 1. (781 aa)
LAMA5Laminin subunit alpha 5. (3457 aa)
LOC105516286Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (449 aa)
WDR72WD repeat domain 72. (1102 aa)
KLK4Kallikrein related peptidase 4; Belongs to the peptidase S1 family. (254 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
GLI3GLI family zinc finger 3. (1580 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1099 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (391 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
DLX3Distal-less homeobox 3. (287 aa)
GLI2GLI family zinc finger 2. (1585 aa)
ENSCANP00000038657Fork-head domain-containing protein. (200 aa)
NECTIN1Nectin cell adhesion molecule 1. (516 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (654 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
DLX2Distal-less homeobox 2. (328 aa)
CTNNA1Catenin alpha 1. (906 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2015 aa)
MSX1Msh homeobox 1. (199 aa)
LRP4LDL receptor related protein 4. (1898 aa)
HTRA1HtrA serine peptidase 1. (384 aa)
SHHSonic hedgehog signaling molecule. (390 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (476 aa)
SERPINE1Serpin family E member 1; Belongs to the serpin family. (337 aa)
CNNM4Cyclin and CBS domain divalent metal cation transport mediator 4. (771 aa)
BAXBCL2 associated X, apoptosis regulator. (198 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (750 aa)
HAND2Uncharacterized protein. (66 aa)
ENAMEnamelin. (1140 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
PPARAPeroxisome proliferator activated receptor alpha. (448 aa)
MMP20Matrix metallopeptidase 20. (483 aa)
ADMAdrenomedullin. (185 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
LOC105527362Uncharacterized protein. (835 aa)
AMBNAmeloblastin. (446 aa)
ANKRD11Ankyrin repeat domain 11. (2647 aa)
BSGBasigin (Ok blood group). (373 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
EDAREctodysplasin A receptor. (480 aa)
ENSCANP00000021244Uncharacterized protein. (198 aa)
RUNX2RUNX family transcription factor 2. (475 aa)
SLC24A4Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (622 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
SCN10ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1943 aa)
SLC34A1Solute carrier family 34 member 1. (639 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1481 aa)
NKX2-3NK2 homeobox 3. (240 aa)
STIM1Stromal interaction molecule 1. (791 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (784 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
KLK5Kallikrein related peptidase 5; Belongs to the peptidase S1 family. (293 aa)
AMTNAmelotin. (209 aa)
NGFRNerve growth factor receptor. (427 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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