STRINGSTRING
TSKU TSKU ABCA2 ABCA2 NR1H3 NR1H3 ABCB11 ABCB11 ANGPTL3 ANGPTL3 NR1H4 NR1H4 CAV3 CAV3 LOC105507530 LOC105507530 APOB APOB IL18 IL18 ENSCANP00000004126 ENSCANP00000004126 HNF4A HNF4A TMEM97 TMEM97 FABP4 FABP4 SOAT2 SOAT2 INSIG1 INSIG1 TTC39B TTC39B TSPO TSPO ABCA1 ABCA1 LPL LPL MTTP MTTP LCAT LCAT CETP CETP LIPC LIPC GPIHBP1 GPIHBP1 CAV1 CAV1 LDLR LDLR SIRT1 SIRT1 APOA5 APOA5 SEC24A SEC24A CYP7A1 CYP7A1 NUS1 NUS1 MALRD1 MALRD1 APOA2 APOA2 EPHX2 EPHX2 DGAT2 DGAT2 G6PC G6PC ABCA5 ABCA5 APOE APOE COMMD9 COMMD9 NR5A2 NR5A2 MYLIP MYLIP LAMTOR1 LAMTOR1 DISP3 DISP3 FGFR4 FGFR4 NPC2 NPC2 LIPG LIPG LOC105502173 LOC105502173 NR1H2 NR1H2 NR1D1 NR1D1 ABCG8 ABCG8 XBP1 XBP1 LIMA1 LIMA1 ENSCANP00000024205 ENSCANP00000024205 ACSM1 ACSM1 ABCG5 ABCG5 ABCG1 ABCG1 ENSCANP00000025349 ENSCANP00000025349 PLSCR3 PLSCR3 CYP7B1 CYP7B1 SREBF2 SREBF2 HDAC9 HDAC9 GRAMD1B GRAMD1B CYP39A1 CYP39A1 RALY RALY SOAT1 SOAT1 NPC1L1 NPC1L1 RALYL RALYL SCARB1 SCARB1 MED13 MED13 NPC1 NPC1 LDLRAP1 LDLRAP1 PCSK9 PCSK9 SLC37A4 SLC37A4 FABP3 FABP3 NFE2L1 NFE2L1 CD24 CD24 ABCG4 ABCG4 LRP5 LRP5 PLA2G12B PLA2G12B TTC39A TTC39A RORA RORA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TSKUTsukushi, small leucine rich proteoglycan. (353 aa)
ABCA2ATP binding cassette subfamily A member 2. (2425 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (453 aa)
ABCB11ATP binding cassette subfamily B member 11. (1321 aa)
ANGPTL3Angiopoietin like 3. (460 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
LOC105507530Uncharacterized protein. (462 aa)
APOBApolipoprotein B. (4555 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ENSCANP00000004126Uncharacterized protein. (79 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (464 aa)
TMEM97Transmembrane protein 97; Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins. (176 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
SOAT2O-acyltransferase. (460 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (277 aa)
TTC39BTetratricopeptide repeat domain 39B. (682 aa)
TSPOUncharacterized protein. (65 aa)
ABCA1ATP binding cassette subfamily A member 1. (2264 aa)
LPLLipoprotein lipase; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans. (475 aa)
MTTPMicrosomal triglyceride transfer protein. (909 aa)
LCATLecithin-cholesterol acyltransferase. (440 aa)
CETPCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (493 aa)
LIPCLipase C, hepatic type. (499 aa)
GPIHBP1Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1. (141 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (179 aa)
LDLRLow density lipoprotein receptor. (777 aa)
SIRT1Sirtuin 1. (600 aa)
APOA5Apolipoprotein A5. (366 aa)
SEC24ASEC24 homolog A, COPII coat complex component. (1078 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (504 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
MALRD1MAM and LDL receptor class A domain containing 1. (2080 aa)
APOA2Apolipoprotein A2. (100 aa)
EPHX2Epoxide hydrolase 2. (547 aa)
DGAT2Diacylglycerol O-acyltransferase 2. (388 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
ABCA5ATP binding cassette subfamily A member 5. (1642 aa)
APOEApolipoprotein E. (189 aa)
COMMD9COMM domain containing 9. (198 aa)
NR5A2Nuclear receptor subfamily 5 group A member 2. (541 aa)
MYLIPMyosin regulatory light chain interacting protein. (445 aa)
LAMTOR1Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1. (161 aa)
DISP3Dispatched RND transporter family member 3. (1390 aa)
FGFR4Fibroblast growth factor receptor. (802 aa)
NPC2NPC intracellular cholesterol transporter 2. (229 aa)
LIPGLipase G, endothelial type. (500 aa)
LOC105502173RRM domain-containing protein. (250 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (459 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (614 aa)
ABCG8ATP binding cassette subfamily G member 8. (620 aa)
XBP1X-box binding protein 1. (204 aa)
LIMA1LIM domain and actin binding 1. (753 aa)
ENSCANP00000024205Lipocln_cytosolic_FA-bd_dom domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (137 aa)
ACSM1Acyl-CoA synthetase medium chain family member 1. (462 aa)
ABCG5ATP binding cassette subfamily G member 5. (651 aa)
ABCG1ATP binding cassette subfamily G member 1. (684 aa)
ENSCANP00000025349Uncharacterized protein. (100 aa)
PLSCR3Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (312 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1123 aa)
HDAC9Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1066 aa)
GRAMD1BGRAM domain containing 1B. (877 aa)
CYP39A1Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (469 aa)
RALYRALY heterogeneous nuclear ribonucleoprotein. (309 aa)
SOAT1O-acyltransferase. (525 aa)
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1326 aa)
RALYLRALY RNA binding protein like. (304 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2173 aa)
NPC1NPC intracellular cholesterol transporter 1. (1277 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (278 aa)
PCSK9Proprotein convertase subtilisin/kexin type 9. (692 aa)
SLC37A4Solute carrier family 37 member 4. (451 aa)
FABP3Fatty acid binding protein 3; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (133 aa)
NFE2L1Nuclear factor, erythroid 2 like 1. (772 aa)
CD24Uncharacterized protein. (127 aa)
ABCG4ATP binding cassette subfamily G member 4. (646 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
PLA2G12BPhospholipase A2 group XIIB. (195 aa)
TTC39ATetratricopeptide repeat domain 39A. (612 aa)
RORARAR related orphan receptor A. (555 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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