STRINGSTRING
ADORA2A ADORA2A MYLK3 MYLK3 LOC105522577 LOC105522577 APOE APOE SLIT2 SLIT2 CDH5 CDH5 FERMT2 FERMT2 NPPB NPPB TJP3 TJP3 PTP4A3 PTP4A3 SH3GL2 SH3GL2 IL18 IL18 ADM ADM PLEC PLEC CTNNBIP1 CTNNBIP1 CEACAM1 CEACAM1 OCLN OCLN DDAH1 DDAH1 TACR2 TACR2 RAMP2 RAMP2 LOC105523238 LOC105523238 YES1 YES1 ANGPT1 ANGPT1 AMOT AMOT TACR1 TACR1 SRC SRC C2CD4C C2CD4C HRH1 HRH1 ABCC8 ABCC8 PDE3A PDE3A GPR4 GPR4 PDE2A PDE2A PTPRJ PTPRJ TRPV4 TRPV4 AZU1 AZU1 AKAP12 AKAP12 TJP1 TJP1 FGFBP3 FGFBP3 TGFB1 TGFB1 BMP6 BMP6 ARHGAP35 ARHGAP35 PLVAP PLVAP NPR1 NPR1 BDKRB2 BDKRB2 BCR BCR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADORA2AAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (412 aa)
MYLK3Myosin light chain kinase 3. (819 aa)
LOC105522577Uncharacterized protein. (399 aa)
APOEApolipoprotein E. (189 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (717 aa)
FERMT2Fermitin family member 2. (687 aa)
NPPBNatriuretic peptide B. (134 aa)
TJP3Tight junction protein 3; Belongs to the MAGUK family. (910 aa)
PTP4A3Protein tyrosine phosphatase 4A3. (173 aa)
SH3GL2SH3 domain containing GRB2 like 2, endophilin A1. (337 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ADMAdrenomedullin. (185 aa)
PLECPlectin. (4128 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
CEACAM1Uncharacterized protein. (525 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (522 aa)
DDAH1Dimethylarginine dimethylaminohydrolase 1. (262 aa)
TACR2Tachykinin receptor 2; Belongs to the G-protein coupled receptor 1 family. (346 aa)
RAMP2Receptor activity modifying protein 2. (216 aa)
LOC105523238Uncharacterized protein. (681 aa)
YES1Tyrosine-protein kinase. (548 aa)
ANGPT1Angiopoietin 1. (498 aa)
AMOTAngiomotin. (1084 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
SRCTyrosine-protein kinase. (458 aa)
C2CD4CC2 calcium dependent domain containing 4C. (421 aa)
HRH1Histamine receptor H1; Belongs to the G-protein coupled receptor 1 family. (487 aa)
ABCC8ATP binding cassette subfamily C member 8. (1577 aa)
PDE3APhosphodiesterase. (1141 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PDE2APhosphodiesterase. (936 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1295 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (871 aa)
AZU1Azurocidin 1. (250 aa)
AKAP12A-kinase anchoring protein 12. (1783 aa)
TJP1Tight junction protein 1; Belongs to the MAGUK family. (1762 aa)
FGFBP3Fibroblast growth factor binding protein 3. (174 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
BMP6Bone morphogenetic protein 6. (331 aa)
ARHGAP35Rho GTPase activating protein 35. (1509 aa)
PLVAPPlasmalemma vesicle associated protein. (442 aa)
NPR1Guanylate cyclase. (958 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (391 aa)
BCRBCR activator of RhoGEF and GTPase. (1127 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.