STRINGSTRING
MTHFD2 MTHFD2 GCLC GCLC OGDH OGDH SHMT1 SHMT1 IDH1 IDH1 FOLR1 FOLR1 PCK2 PCK2 DLST DLST ENSCANP00000003146 ENSCANP00000003146 ALDH1L1 ALDH1L1 ENSCANP00000003194 ENSCANP00000003194 ALDH1L2 ALDH1L2 LOC105508096 LOC105508096 ENSCANP00000004241 ENSCANP00000004241 LOC105510446 LOC105510446 SLC19A1 SLC19A1 GRHPR GRHPR ME3 ME3 OGDHL OGDHL ENSCANP00000006489 ENSCANP00000006489 DGLUCY DGLUCY ASS1 ASS1 KMO KMO QPRT QPRT ENSCANP00000010064 ENSCANP00000010064 ME2 ME2 ENSCANP00000010799 ENSCANP00000010799 LOC105514359 LOC105514359 MDH1B MDH1B IDH2 IDH2 ACLY ACLY MTHFD2L MTHFD2L NAGS NAGS GOT1L1 GOT1L1 LOC105525737 LOC105525737 GOT1 GOT1 ACSF3 ACSF3 ADSS2 ADSS2 LOC105501429 LOC105501429 FTCD FTCD TAT TAT ASPA ASPA PCK1 PCK1 LOC105514124 LOC105514124 HAL HAL UROC1 UROC1 KYAT3 KYAT3 GAD1 GAD1 ENSCANP00000018431 ENSCANP00000018431 OAT OAT SHMT2 SHMT2 ENSCANP00000019220 ENSCANP00000019220 MTHFD1L MTHFD1L ENSCANP00000019959 ENSCANP00000019959 ENSCANP00000020094 ENSCANP00000020094 ALDH5A1 ALDH5A1 ENSCANP00000020568 ENSCANP00000020568 ENSCANP00000020639 ENSCANP00000020639 NIT2 NIT2 ENSCANP00000021881 ENSCANP00000021881 AADAT AADAT ENSCANP00000022718 ENSCANP00000022718 MDH2 MDH2 LOC105523237 LOC105523237 MTRR MTRR ADHFE1 ADHFE1 MDH1 MDH1 PHYH PHYH ENSCANP00000025188 ENSCANP00000025188 LOC105519891 LOC105519891 GOT2 GOT2 FH FH ALDH18A1 ALDH18A1 GAD2 GAD2 ACOT8 ACOT8 LIPF LIPF LOC105518232 LOC105518232 ENSCANP00000028804 ENSCANP00000028804 PRODH2 PRODH2 SDHAF3 SDHAF3 SLC46A1 SLC46A1 SDHB SDHB GPT2 GPT2 ALDH4A1 ALDH4A1 AASDHPPT AASDHPPT KYNU KYNU ENSCANP00000031967 ENSCANP00000031967 DDO DDO ENSCANP00000032715 ENSCANP00000032715 ME1 ME1 ST20-MTHFS ST20-MTHFS DHFR DHFR LOC105519911 LOC105519911 LOC105517438 LOC105517438 AMDHD1 AMDHD1 GCLM GCLM ENSCANP00000035521 ENSCANP00000035521 ENSCANP00000036168 ENSCANP00000036168 GLS GLS HAAO HAAO GLS2 GLS2 D2HGDH D2HGDH L2HGDH L2HGDH DHFR2 DHFR2 MTHFD1 MTHFD1 ENSCANP00000038566 ENSCANP00000038566 FPGS FPGS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTHFD2Uncharacterized protein. (337 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (637 aa)
OGDHOxoglutarate dehydrogenase. (1010 aa)
SHMT1Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (434 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
FOLR1Folate receptor alpha. (257 aa)
PCK2Phosphoenolpyruvate carboxykinase 2, mitochondrial. (645 aa)
DLSTDihydrolipoamide S-succinyltransferase. (454 aa)
ENSCANP00000003146Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (433 aa)
ALDH1L110-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (904 aa)
ENSCANP00000003194Uncharacterized protein. (103 aa)
ALDH1L210-formyltetrahydrofolate dehydrogenase; In the N-terminal section; belongs to the GART family. (916 aa)
LOC105508096DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (176 aa)
ENSCANP00000004241SHMT domain-containing protein. (396 aa)
LOC105510446Uncharacterized protein. (103 aa)
SLC19A1Solute carrier family 19 member 1. (586 aa)
GRHPRGlyoxylate and hydroxypyruvate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (358 aa)
ME3Malic enzyme. (604 aa)
OGDHLOxoglutarate dehydrogenase like. (982 aa)
ENSCANP00000006489ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (267 aa)
DGLUCYD-glutamate cyclase. (614 aa)
ASS1Argininosuccinate synthase 1. (391 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (485 aa)
QPRTNicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (305 aa)
ENSCANP00000010064Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (416 aa)
ME2Malic enzyme. (584 aa)
ENSCANP00000010799CN hydrolase domain-containing protein. (272 aa)
LOC105514359Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (567 aa)
MDH1BUncharacterized protein. (517 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (443 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1123 aa)
MTHFD2LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like. (347 aa)
NAGSN-acetylglutamate synthase. (535 aa)
GOT1L1Glutamic-oxaloacetic transaminase 1 like 1. (421 aa)
LOC105525737Uncharacterized protein. (463 aa)
GOT1Aspartate aminotransferase. (413 aa)
ACSF3Acyl-CoA synthetase family member 3. (576 aa)
ADSS2Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
LOC105501429Uncharacterized protein. (264 aa)
FTCDFormimidoyltransferase cyclodeaminase. (475 aa)
TATTyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (454 aa)
ASPAAspartoacylase. (313 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
LOC105514124DHFR domain-containing protein. (170 aa)
HALHistidine ammonia-lyase; Belongs to the PAL/histidase family. (657 aa)
UROC1Urocanate hydratase 1. (742 aa)
KYAT3Kynurenine aminotransferase 3. (454 aa)
GAD1Glutamate decarboxylase 1. (594 aa)
ENSCANP00000018431Uncharacterized protein. (102 aa)
OATOrnithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (332 aa)
SHMT2Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (504 aa)
ENSCANP000000192204Fe-4S ferredoxin-type domain-containing protein. (280 aa)
MTHFD1LMethylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (896 aa)
ENSCANP00000019959Uncharacterized protein. (186 aa)
ENSCANP00000020094Aspartate aminotransferase. (358 aa)
ALDH5A1Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (535 aa)
ENSCANP00000020568Uncharacterized protein. (455 aa)
ENSCANP00000020639Uncharacterized protein. (287 aa)
NIT2Nitrilase family member 2. (307 aa)
ENSCANP00000021881FAD_binding_2 domain-containing protein. (204 aa)
AADATAminoadipate aminotransferase. (429 aa)
ENSCANP00000022718Uncharacterized protein. (361 aa)
MDH2Malate dehydrogenase. (338 aa)
LOC105523237Uncharacterized protein. (561 aa)
MTRR5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (698 aa)
ADHFE1Fe-ADH domain-containing protein. (467 aa)
MDH1Malate dehydrogenase. (352 aa)
PHYHPhytanoyl-CoA 2-hydroxylase. (325 aa)
ENSCANP00000025188ELFV_dehydrog domain-containing protein. (244 aa)
LOC105519891Aspartate aminotransferase. (424 aa)
GOT2Uncharacterized protein. (257 aa)
FHFumarate hydratase. (510 aa)
ALDH18A1Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa)
GAD2Glutamate decarboxylase 2. (564 aa)
ACOT8Acyl-CoA thioesterase 8. (319 aa)
LIPFLipase; Belongs to the AB hydrolase superfamily. Lipase family. (408 aa)
LOC105518232Malate dehydrogenase. (338 aa)
ENSCANP00000028804Uncharacterized protein. (103 aa)
PRODH2Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (417 aa)
SDHAF3Uncharacterized protein. (125 aa)
SLC46A1Solute carrier family 46 member 1. (459 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (280 aa)
GPT2Glutamic--pyruvic transaminase 2. (523 aa)
ALDH4A1Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (563 aa)
AASDHPPTAminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase. (309 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (465 aa)
ENSCANP00000031967Aminotran_1_2 domain-containing protein. (355 aa)
DDOD-aspartate oxidase. (369 aa)
ENSCANP00000032715Uncharacterized protein. (321 aa)
ME1Malic enzyme. (572 aa)
ST20-MTHFS5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (225 aa)
DHFRDHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (187 aa)
LOC105519911ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (549 aa)
LOC105517438ELFV_dehydrog domain-containing protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (261 aa)
AMDHD1Amidohydrolase domain containing 1. (426 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (262 aa)
ENSCANP00000035521THF_DHG_CYH_C domain-containing protein. (873 aa)
ENSCANP00000036168Aminotran_1_2 domain-containing protein. (372 aa)
GLSGlutaminase. (669 aa)
HAAO3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa)
GLS2Glutaminase 2. (603 aa)
D2HGDHD-2-hydroxyglutarate dehydrogenase. (423 aa)
L2HGDHL-2-hydroxyglutarate dehydrogenase. (463 aa)
DHFR2Dihydrofolate reductase 2; Belongs to the dihydrofolate reductase family. (168 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (986 aa)
ENSCANP00000038566Uncharacterized protein. (400 aa)
FPGSFolylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (570 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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