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ACVR1 ACVR1 LTF LTF SOX11 SOX11 WDR63 WDR63 LRP5 LRP5 IL6 IL6 TP63 TP63 FFAR4 FFAR4 CCN4 CCN4 PRKD1 PRKD1 CTHRC1 CTHRC1 HGF HGF NPPC NPPC BMPR2 BMPR2 SUCO SUCO LOC105506399 LOC105506399 SCUBE3 SCUBE3 IL6R IL6R WWTR1 WWTR1 PPP3CA PPP3CA CTNNBIP1 CTNNBIP1 ACVR2B ACVR2B WNT4 WNT4 JAG1 JAG1 GDPD2 GDPD2 ATRAID ATRAID NELL1 NELL1 BMP7 BMP7 PDLIM7 PDLIM7 ENSCANP00000021741 ENSCANP00000021741 FERMT2 FERMT2 RUNX2 RUNX2 IGF1 IGF1 SMAD1 SMAD1 SFRP2 SFRP2 SMAD5 SMAD5 IL6ST IL6ST ENSCANP00000015600 ENSCANP00000015600 GLI3 GLI3 YAP1 YAP1 WNT10B WNT10B BMP4 BMP4 BMPR1A BMPR1A DDR2 DDR2 BMP2 BMP2 FBXO5 FBXO5 SCUBE2 SCUBE2 FBN2 FBN2 CTNNB1 CTNNB1 ENSCANP00000010884 ENSCANP00000010884 TENT5A TENT5A ZHX3 ZHX3 BMP6 BMP6 BMPR1B BMPR1B MEF2C MEF2C CLIC1 CLIC1 GDF10 GDF10 ACVR2A ACVR2A WNT7B WNT7B CCN1 CCN1 TMEM119 TMEM119 LRP3 LRP3 FAM20C FAM20C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
LTFLactotransferrin; Belongs to the transferrin family. (710 aa)
SOX11Transcription factor SOX. (372 aa)
WDR63WD repeat domain 63. (874 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
IL6Interleukin 6. (214 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (654 aa)
FFAR4Free fatty acid receptor 4. (377 aa)
CCN4Cellular communication network factor 4. (367 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
CTHRC1Collagen triple helix repeat containing 1. (147 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (728 aa)
NPPCNatriuretic peptide C. (126 aa)
BMPR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1030 aa)
SUCOSUN domain containing ossification factor. (1394 aa)
LOC105506399Uncharacterized protein. (246 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (993 aa)
IL6RInterleukin 6 receptor. (568 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
PPP3CASerine/threonine-protein phosphatase. (521 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (750 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1089 aa)
GDPD2Glycerophosphodiester phosphodiesterase domain containing 2. (589 aa)
ATRAIDAll-trans retinoic acid induced differentiation factor. (283 aa)
NELL1Neural EGFL like 1. (810 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PDLIM7PDZ and LIM domain 7. (440 aa)
ENSCANP00000021741Uncharacterized protein. (197 aa)
FERMT2Fermitin family member 2. (687 aa)
RUNX2RUNX family transcription factor 2. (475 aa)
IGF1Insulin like growth factor 1. (208 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
IL6STInterleukin 6 signal transducer. (860 aa)
ENSCANP00000015600Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (223 aa)
GLI3GLI family zinc finger 3. (1580 aa)
YAP1Yes associated protein 1. (479 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
FBXO5F-box protein 5. (448 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (954 aa)
FBN2Fibrillin 2. (2912 aa)
CTNNB1Catenin beta 1. (781 aa)
ENSCANP00000010884Uncharacterized protein. (338 aa)
TENT5ATerminal nucleotidyltransferase 5A. (500 aa)
ZHX3Zinc fingers and homeoboxes 3. (968 aa)
BMP6Bone morphogenetic protein 6. (331 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
CLIC1Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (241 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (474 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (515 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
CCN1Cellular communication network factor 1. (381 aa)
TMEM119Transmembrane protein 119. (283 aa)
LRP3LDL receptor related protein 3. (771 aa)
FAM20CFAM20C golgi associated secretory pathway kinase. (365 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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