(39 nodes) Positive regulation of DNA replication network (Colobus angolensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	CDT1	Chromatin licensing and DNA replication factor 1. (470 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (362 aa)
	ATRX	ATRX chromatin remodeler. (2490 aa)
	EGFR	Receptor protein-tyrosine kinase. (1188 aa)
	DHX9	DExH-box helicase 9. (1275 aa)
	EGF	Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
	E2F7	E2F transcription factor 7. (910 aa)
	EREG	Epiregulin. (169 aa)
	DBF4B	DBF4 zinc finger B. (603 aa)
	MAP2K4	Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (373 aa)
	FAF1	Fas associated factor 1. (650 aa)
	BAZ1A	Bromodomain adjacent to zinc finger domain 1A. (1551 aa)
	KCTD13	Potassium channel tetramerization domain containing 13. (332 aa)
	INO80	INO80 complex ATPase subunit. (1492 aa)
	E2F8	E2F transcription factor 8. (867 aa)
	DBF4	DBF4 zinc finger. (674 aa)
	BCAR3	BCAR3 adaptor protein, NSP family member. (825 aa)
	NPM2	Nucleophosmin/nucleoplasmin 2. (214 aa)
	KAT7	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (611 aa)
	CIZ1	CDKN1A interacting zinc finger protein 1. (926 aa)
	ENSCANP00000034313	Protein kinase domain-containing protein. (543 aa)
	SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1052 aa)
	GLI2	GLI family zinc finger 2. (1585 aa)
	SSBP1	Single stranded DNA binding protein 1. (148 aa)
	NRM	Nurim. (261 aa)
	GLI1	GLI family zinc finger 1. (1065 aa)
	WIZ	WIZ zinc finger. (968 aa)
	CDC7	Protein kinase domain-containing protein. (574 aa)
	BRPF3	Bromodomain and PHD finger containing 3. (1205 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
	DNA2	DNA replication helicase/nuclease 2. (1042 aa)
	STOML2	Stomatin like 2. (361 aa)
	ATAD5	ATPase family AAA domain containing 5. (1726 aa)
	ATF1	Activating transcription factor 1. (270 aa)
	ENSCANP00000006830	Protein kinase domain-containing protein. (373 aa)
	MAS1	MAS1 proto-oncogene, G protein-coupled receptor; Belongs to the G-protein coupled receptor 1 family. (325 aa)
	CTC1	CST telomere replication complex component 1. (1212 aa)
	LOC105509448	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (245 aa)
	LPIN1	Lipin 1. (975 aa)

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	BRPF3	ENSCANP00000011146	ENSCANP00000014553	ATPase family AAA domain containing 5.	Bromodomain and PHD finger containing 3.	0.602
ATAD5	CDT1	ENSCANP00000011146	ENSCANP00000009900	ATPase family AAA domain containing 5.	Chromatin licensing and DNA replication factor 1.	0.859
ATAD5	CTC1	ENSCANP00000011146	ENSCANP00000006474	ATPase family AAA domain containing 5.	CST telomere replication complex component 1.	0.507
ATAD5	DNA2	ENSCANP00000011146	ENSCANP00000012144	ATPase family AAA domain containing 5.	DNA replication helicase/nuclease 2.	0.910
ATAD5	LOC105509448	ENSCANP00000011146	ENSCANP00000005226	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.949
ATAD5	PCNA	ENSCANP00000011146	ENSCANP00000015524	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.949
ATRX	LOC105509448	ENSCANP00000017502	ENSCANP00000005226	ATRX chromatin remodeler.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.426
ATRX	PCNA	ENSCANP00000017502	ENSCANP00000015524	ATRX chromatin remodeler.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.426
BAZ1A	SMARCA5	ENSCANP00000022569	ENSCANP00000035876	Bromodomain adjacent to zinc finger domain 1A.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5.	0.981
BRPF3	ATAD5	ENSCANP00000014553	ENSCANP00000011146	Bromodomain and PHD finger containing 3.	ATPase family AAA domain containing 5.	0.602
BRPF3	KAT7	ENSCANP00000014553	ENSCANP00000032931	Bromodomain and PHD finger containing 3.	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family.	0.950
CDC7	CDK2	ENSCANP00000013607	ENSCANP00000016039	Protein kinase domain-containing protein.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.684
CDC7	CDT1	ENSCANP00000013607	ENSCANP00000009900	Protein kinase domain-containing protein.	Chromatin licensing and DNA replication factor 1.	0.800
CDC7	DBF4	ENSCANP00000013607	ENSCANP00000031882	Protein kinase domain-containing protein.	DBF4 zinc finger.	0.969
CDC7	DBF4B	ENSCANP00000013607	ENSCANP00000021806	Protein kinase domain-containing protein.	DBF4 zinc finger B.	0.920
CDK2	CDC7	ENSCANP00000016039	ENSCANP00000013607	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.684
CDK2	CDT1	ENSCANP00000016039	ENSCANP00000009900	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Chromatin licensing and DNA replication factor 1.	0.891
CDK2	DBF4	ENSCANP00000016039	ENSCANP00000031882	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	DBF4 zinc finger.	0.628
CDK2	DBF4B	ENSCANP00000016039	ENSCANP00000021806	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	DBF4 zinc finger B.	0.468
CDK2	ENSCANP00000034313	ENSCANP00000016039	ENSCANP00000034313	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.684