(40 nodes) Oocyte development network (Colobus angolensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1266 aa)
	EDN1	Endothelin 1. (211 aa)
	YBX2	Y-box binding protein 2. (276 aa)
	PDE3A	Phosphodiesterase. (1141 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (587 aa)
	BCL2	BCL2 apoptosis regulator. (239 aa)
	TDRD15	Tudor domain containing 15. (1738 aa)
	TRIP13	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family. (432 aa)
	CDC25B	Cell division cycle 25B. (580 aa)
	YTHDC2	YTH domain containing 2. (1432 aa)
	PDE5A	Phosphodiesterase. (875 aa)
	BRCA2	BRCA2 DNA repair associated. (3412 aa)
	GDF9	Growth differentiation factor 9. (366 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	FBXO5	F-box protein 5. (448 aa)
	KMT2D	Lysine methyltransferase 2D. (5549 aa)
	WDR77	WD repeat domain 77. (342 aa)
	TDRD6	Tudor domain containing 6. (2097 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3056 aa)
	FIGLA	Folliculogenesis specific bHLH transcription factor. (210 aa)
	PLD6	Phospholipase D family member 6. (172 aa)
	EREG	Epiregulin. (169 aa)
	REC8	REC8 meiotic recombination protein. (544 aa)
	EDNRA	Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
	TDRD10	Tudor domain containing 10. (366 aa)
	TDRD1	Tudor domain containing 1. (1189 aa)
	TUT7	Terminal uridylyl transferase 7. (1490 aa)
	TUT4	Terminal uridylyl transferase 4. (1649 aa)
	WNT4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
	TDRKH	Tudor and KH domain containing. (561 aa)
	PABPC1L	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (612 aa)
	TDRD5	Tudor domain containing 5. (1032 aa)
	AURKC	Aurora kinase C. (259 aa)
	MEIOC	Meiosis specific with coiled-coil domain. (931 aa)
	DMC1	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (321 aa)
	MTHFSD	Methenyltetrahydrofolate synthetase domain containing. (383 aa)
	DMRT1	Doublesex and mab-3 related transcription factor 1. (373 aa)
	RPS6KA2	Ribosomal protein S6 kinase. (758 aa)
	ZGLP1	Zinc finger GATA like protein 1. (249 aa)

Your Current Organism:

Colobus angolensis

NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	BCL2	ENSCANP00000015871	ENSCANP00000004710	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BCL2 apoptosis regulator.	0.413
ATM	BRCA2	ENSCANP00000015871	ENSCANP00000010241	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	BRCA2 DNA repair associated.	0.924
ATM	DMC1	ENSCANP00000015871	ENSCANP00000034797	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.798
AURKC	TRIP13	ENSCANP00000029383	ENSCANP00000006029	Aurora kinase C.	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.509
BCL2	ATM	ENSCANP00000004710	ENSCANP00000015871	BCL2 apoptosis regulator.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.413
BCL2	CTNNB1	ENSCANP00000004710	ENSCANP00000011681	BCL2 apoptosis regulator.	Catenin beta 1.	0.447
BCL2	DMRT1	ENSCANP00000004710	ENSCANP00000036583	BCL2 apoptosis regulator.	Doublesex and mab-3 related transcription factor 1.	0.416
BRCA2	ATM	ENSCANP00000010241	ENSCANP00000015871	BRCA2 DNA repair associated.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.924
BRCA2	DMC1	ENSCANP00000010241	ENSCANP00000034797	BRCA2 DNA repair associated.	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	0.950
CTNNB1	BCL2	ENSCANP00000011681	ENSCANP00000004710	Catenin beta 1.	BCL2 apoptosis regulator.	0.447
CTNNB1	DMRT1	ENSCANP00000011681	ENSCANP00000036583	Catenin beta 1.	Doublesex and mab-3 related transcription factor 1.	0.493
CTNNB1	KMT2D	ENSCANP00000011681	ENSCANP00000012826	Catenin beta 1.	Lysine methyltransferase 2D.	0.628
CTNNB1	WNT4	ENSCANP00000011681	ENSCANP00000026959	Catenin beta 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.641
DMC1	ATM	ENSCANP00000034797	ENSCANP00000015871	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.798
DMC1	BRCA2	ENSCANP00000034797	ENSCANP00000010241	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	BRCA2 DNA repair associated.	0.950
DMC1	REC8	ENSCANP00000034797	ENSCANP00000021070	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	REC8 meiotic recombination protein.	0.530
DMC1	TRIP13	ENSCANP00000034797	ENSCANP00000006029	Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily.	Thyroid hormone receptor interactor 13; Belongs to the AAA ATPase family.	0.853
DMRT1	BCL2	ENSCANP00000036583	ENSCANP00000004710	Doublesex and mab-3 related transcription factor 1.	BCL2 apoptosis regulator.	0.416
DMRT1	CTNNB1	ENSCANP00000036583	ENSCANP00000011681	Doublesex and mab-3 related transcription factor 1.	Catenin beta 1.	0.493
DMRT1	FIGLA	ENSCANP00000036583	ENSCANP00000016254	Doublesex and mab-3 related transcription factor 1.	Folliculogenesis specific bHLH transcription factor.	0.511