STRINGSTRING
ITGB3 ITGB3 XBP1 XBP1 AIF1 AIF1 CYBA CYBA ENSCANP00000022502 ENSCANP00000022502 TGFB1 TGFB1 APLN APLN FOXJ2 FOXJ2 SERPINF2 SERPINF2 VIP VIP THBS1 THBS1 TERT TERT EREG EREG MNAT1 MNAT1 PPARGC1A PPARGC1A IGF1 IGF1 ELANE ELANE ZNF143 ZNF143 IRAK1 IRAK1 APOE APOE NOTCH3 NOTCH3 LOC105506260 LOC105506260 ADAMTS1 ADAMTS1 MMP9 MMP9 NPPC NPPC ELN ELN LOC105502827 LOC105502827 BMPR2 BMPR2 TGFB3 TGFB3 EFEMP2 EFEMP2 JUN JUN NPR3 NPR3 ID2 ID2 IL6R IL6R CNN1 CNN1 IRAK4 IRAK4 HTR1B HTR1B CTNNBIP1 CTNNBIP1 TLR4 TLR4 ALOX12 ALOX12 NR4A3 NR4A3 SRC SRC TACR1 TACR1 CCDC142 CCDC142 FRS2 FRS2 IL6 IL6 ENSCANP00000038012 ENSCANP00000038012 ITGA2 ITGA2 DBH DBH SF1 SF1 LDLRAP1 LDLRAP1 IL12A IL12A GNA13 GNA13 IL10 IL10 CCN4 CCN4 SMPD3 SMPD3 ENSCANP00000035234 ENSCANP00000035234 GNA12 GNA12 PDGFRB PDGFRB NDRG2 NDRG2 FOXP1 FOXP1 PDCD4 PDCD4 ENSCANP00000009344 ENSCANP00000009344 PTEN PTEN CX3CL1 CX3CL1 MFN2 MFN2 CTNNB1 CTNNB1 BMP2 BMP2 IGF1R IGF1R DDR2 DDR2 NPR1 NPR1 BMPR1A BMPR1A BMP4 BMP4 RPS6KB1 RPS6KB1 IFNG IFNG AKT1 AKT1 XRCC5 XRCC5 NOS3 NOS3 PRKDC PRKDC XRCC6 XRCC6 PDGFB PDGFB PIK3CA PIK3CA CALCRL CALCRL PRKG1 PRKG1 TCF7L2 TCF7L2 ERN1 ERN1 LOC105523325 LOC105523325 FGF9 FGF9 PPARD PPARD FGFR2 FGFR2 PTGS2 PTGS2 VIPR2 VIPR2 DNMT1 DNMT1 TRIB1 TRIB1 PHB PHB P2RY6 P2RY6 MYOCD MYOCD TNFAIP3 TNFAIP3 IGFBP5 IGFBP5 STAT1 STAT1 ADIPOQ ADIPOQ CDKN1A CDKN1A CDKN1B CDKN1B MAP3K5 MAP3K5 MEF2D MEF2D GPER1 GPER1 IL18 IL18 RBM10 RBM10 EDN1 EDN1 S1PR2 S1PR2 S1PR1 S1PR1 PTGIR PTGIR NPY5R NPY5R LOC105523135 LOC105523135 APOD APOD NDRG4 NDRG4 TGFBR2 TGFBR2 NOX1 NOX1 HBEGF HBEGF MEF2C MEF2C SOD2 SOD2 IGFBP3 IGFBP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
XBP1X-box binding protein 1. (204 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
ENSCANP00000022502Prohibitin. (185 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
APLNApelin. (77 aa)
FOXJ2Forkhead box J2. (548 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
VIPVasoactive intestinal peptide. (170 aa)
THBS1Thrombospondin 1. (1173 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1059 aa)
EREGEpiregulin. (169 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
PPARGC1APPARG coactivator 1 alpha. (798 aa)
IGF1Insulin like growth factor 1. (208 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (265 aa)
ZNF143Zinc finger protein 143. (637 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (648 aa)
APOEApolipoprotein E. (189 aa)
NOTCH3Notch receptor 3. (2021 aa)
LOC105506260X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (658 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
NPPCNatriuretic peptide C. (126 aa)
ELNElastin. (703 aa)
LOC105502827Prohibitin. (244 aa)
BMPR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1030 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (443 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
NPR3Natriuretic peptide receptor 3. (543 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
IL6RInterleukin 6 receptor. (568 aa)
CNN1Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (297 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (438 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (618 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (549 aa)
SRCTyrosine-protein kinase. (458 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
CCDC142Coiled-coil domain containing 142. (750 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
IL6Interleukin 6. (214 aa)
ENSCANP00000038012Prohibitin. (190 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
DBHDopamine beta-hydroxylase. (620 aa)
SF1Splicing factor 1. (639 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (278 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (253 aa)
GNA13G protein subunit alpha 13. (282 aa)
IL10Interleukin 10. (178 aa)
CCN4Cellular communication network factor 4. (367 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
ENSCANP00000035234Prohibitin. (260 aa)
GNA12G protein subunit alpha 12. (310 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
NDRG2NDRG family member 2. (334 aa)
FOXP1Forkhead box P1. (693 aa)
PDCD4Programmed cell death 4. (470 aa)
ENSCANP00000009344Uncharacterized protein. (627 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (402 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (387 aa)
CTNNB1Catenin beta 1. (781 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
NPR1Guanylate cyclase. (958 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (165 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (732 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4128 aa)
XRCC6X-ray repair cross complementing 6. (609 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (220 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (461 aa)
PRKG1cGMP-dependent protein kinase. (686 aa)
TCF7L2Transcription factor 7 like 2. (577 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (979 aa)
LOC105523325Uncharacterized protein. (284 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
VIPR2Vasoactive intestinal peptide receptor 2; Belongs to the G-protein coupled receptor 2 family. (421 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1646 aa)
TRIB1Tribbles pseudokinase 1. (206 aa)
PHBProhibitin. (272 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
MYOCDMyocardin. (923 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
STAT1Signal transducer and activator of transcription. (765 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1364 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
RBM10RNA binding motif protein 10. (995 aa)
EDN1Endothelin 1. (211 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
PTGIRProstaglandin I2 receptor. (386 aa)
NPY5RNeuropeptide Y receptor Y5. (445 aa)
LOC105523135Ku domain-containing protein. (596 aa)
APODApolipoprotein D. (175 aa)
NDRG4NDRG family member 4. (378 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
NOX1NADPH oxidase 1. (522 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (236 aa)
IGFBP3Insulin like growth factor binding protein 3. (189 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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