STRINGSTRING
AKT1 AKT1 SRC SRC FRS2 FRS2 IL6 IL6 ENSCANP00000038012 ENSCANP00000038012 ITGA2 ITGA2 LDLRAP1 LDLRAP1 CCN4 CCN4 SMPD3 SMPD3 ENSCANP00000035234 ENSCANP00000035234 ADAMTS1 ADAMTS1 MMP9 MMP9 LOC105502827 LOC105502827 JUN JUN ID2 ID2 IL6R IL6R IRAK4 IRAK4 HTR1B HTR1B TLR4 TLR4 ALOX12 ALOX12 NR4A3 NR4A3 PHB PHB P2RY6 P2RY6 IGFBP5 IGFBP5 STAT1 STAT1 MAP3K5 MAP3K5 MEF2D MEF2D ITGB3 ITGB3 XBP1 XBP1 AIF1 AIF1 CYBA CYBA ENSCANP00000022502 ENSCANP00000022502 FOXJ2 FOXJ2 SERPINF2 SERPINF2 THBS1 THBS1 TERT TERT EREG EREG MNAT1 MNAT1 IGF1 IGF1 ELANE ELANE ZNF143 ZNF143 IRAK1 IRAK1 NOTCH3 NOTCH3 DNMT1 DNMT1 PTGS2 PTGS2 FGFR2 FGFR2 FGF9 FGF9 LOC105523325 LOC105523325 ERN1 ERN1 CALCRL CALCRL PIK3CA PIK3CA PDGFB PDGFB RPS6KB1 RPS6KB1 BMP4 BMP4 BMPR1A BMPR1A DDR2 DDR2 IGF1R IGF1R MFN2 MFN2 CX3CL1 CX3CL1 ENSCANP00000009344 ENSCANP00000009344 FOXP1 FOXP1 PDGFRB PDGFRB TGFB1 TGFB1 HBEGF HBEGF NOX1 NOX1 TGFBR2 TGFBR2 NPY5R NPY5R S1PR1 S1PR1 EDN1 EDN1 IL18 IL18
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
SRCTyrosine-protein kinase. (458 aa)
FRS2Fibroblast growth factor receptor substrate 2. (521 aa)
IL6Interleukin 6. (214 aa)
ENSCANP00000038012Prohibitin. (190 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1180 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (278 aa)
CCN4Cellular communication network factor 4. (367 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (655 aa)
ENSCANP00000035234Prohibitin. (260 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
MMP9Matrix metallopeptidase 9. (707 aa)
LOC105502827Prohibitin. (244 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
IL6RInterleukin 6 receptor. (568 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (438 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
ALOX12Arachidonate 12-lipoxygenase, 12S type. (618 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (549 aa)
PHBProhibitin. (272 aa)
P2RY6Pyrimidinergic receptor P2Y6. (328 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
STAT1Signal transducer and activator of transcription. (765 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1364 aa)
MEF2DMyocyte enhancer factor 2D. (521 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
XBP1X-box binding protein 1. (204 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
ENSCANP00000022502Prohibitin. (185 aa)
FOXJ2Forkhead box J2. (548 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
THBS1Thrombospondin 1. (1173 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1059 aa)
EREGEpiregulin. (169 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
IGF1Insulin like growth factor 1. (208 aa)
ELANEElastase, neutrophil expressed; Belongs to the peptidase S1 family. (265 aa)
ZNF143Zinc finger protein 143. (637 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (648 aa)
NOTCH3Notch receptor 3. (2021 aa)
DNMT1DNA (cytosine-5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1646 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
LOC105523325Uncharacterized protein. (284 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (979 aa)
CALCRLCalcitonin receptor like receptor; Belongs to the G-protein coupled receptor 2 family. (461 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (220 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
IGF1RTyrosine-protein kinase receptor. (1335 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (387 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (402 aa)
ENSCANP00000009344Uncharacterized protein. (627 aa)
FOXP1Forkhead box P1. (693 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
HBEGFHeparin binding EGF like growth factor. (208 aa)
NOX1NADPH oxidase 1. (522 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
NPY5RNeuropeptide Y receptor Y5. (445 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
EDN1Endothelin 1. (211 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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