STRINGSTRING
VWA5A VWA5A MYL3 MYL3 MYH6 MYH6 SIRT6 SIRT6 ENSCANP00000038657 ENSCANP00000038657 ANKRD1 ANKRD1 ISL1 ISL1 ARID2 ARID2 C10orf113 C10orf113 GATA4 GATA4 POU4F1 POU4F1 HOPX HOPX ENSCANP00000036326 ENSCANP00000036326 NEB NEB CHD7 CHD7 XIRP2 XIRP2 TBX20 TBX20 SCN5A SCN5A COL11A1 COL11A1 LRP2 LRP2 TNNI1 TNNI1 EGLN1 EGLN1 WNT5A WNT5A TBX18 TBX18 LOC105511833 LOC105511833 OBSL1 OBSL1 TTN TTN SHOX2 SHOX2 ENSCANP00000030255 ENSCANP00000030255 JARID2 JARID2 PROX1 PROX1 TGFBR1 TGFBR1 SMAD4 SMAD4 BMP10 BMP10 LOC105515123 LOC105515123 SLC8A1 SLC8A1 SGCB SGCB PLEC PLEC WNT3A WNT3A WT1 WT1 PPP1R13L PPP1R13L NRG1 NRG1 RARB RARB NOTCH1 NOTCH1 MYOCD MYOCD NPPA NPPA SRF SRF HAND1 HAND1 ASB2 ASB2 TAZ TAZ NRAP NRAP IFT20 IFT20 MYH11 MYH11 PTCD2 PTCD2 TNNT2 TNNT2 ALPK2 ALPK2 ATG5 ATG5 MEF2A MEF2A BMP7 BMP7 PRMT1 PRMT1 MAP2K4 MAP2K4 NEBL NEBL CBY1 CBY1 MTOR MTOR GATA5 GATA5 NPPB NPPB EDNRA EDNRA HEY2 HEY2 SLC9A1 SLC9A1 LMNA LMNA TGFB2 TGFB2 CXADR CXADR DIPK2A DIPK2A ZFPM2 ZFPM2 TBX5 TBX5 FGFR2 FGFR2 FGF9 FGF9 BVES BVES ADRA1A ADRA1A SMAD1 SMAD1 CSRP3 CSRP3 WNT2 WNT2 RARA RARA ADAMTS9 ADAMTS9 TGFBR3 TGFBR3 MAML1 MAML1 TBX3 TBX3 ALPK3 ALPK3 DLL4 DLL4 WNT8A WNT8A BMP4 BMP4 BMPR1A BMPR1A HEG1 HEG1 BMP2 BMP2 ACVR1 ACVR1 FOXH1 FOXH1 SGCZ SGCZ DSG2 DSG2 VWA5B1 VWA5B1 TENM4 TENM4 FHOD3 FHOD3 AKAP13 AKAP13 PTEN PTEN SORBS2 SORBS2 MYBPC3 MYBPC3 TNNI3 TNNI3 VWA5B2 VWA5B2 NKX2-6 NKX2-6 PDGFRB PDGFRB DSP DSP TGFB1 TGFB1 NOTCH2 NOTCH2 NKX2-5 NKX2-5 BMP5 BMP5 FHL2 FHL2 MYH7 MYH7 MYO18B MYO18B IRX3 IRX3 SAV1 SAV1 MSC MSC HNRNPU HNRNPU KDM6B KDM6B ENSCANP00000006830 ENSCANP00000006830 MEF2C MEF2C SMAD7 SMAD7 ZMPSTE24 ZMPSTE24 NPRL3 NPRL3 GATA6 GATA6 ZIC3 ZIC3 SGCD SGCD TCAP TCAP TSC1 TSC1 PLN PLN TBX2 TBX2 RYR2 RYR2 GJB6 GJB6 NOG NOG NDRG4 NDRG4 ACTN2 ACTN2 LRRC10 LRRC10 CAV3 CAV3 ENG ENG MYL10 MYL10 PDLIM5 PDLIM5 S1PR1 S1PR1 GJA5 GJA5 CACNA1G CACNA1G MYL2 MYL2 MAPK11 MAPK11 HEY1 HEY1 ALDH1A2 ALDH1A2 GJC1 GJC1 PKP2 PKP2 SGCG SGCG MED1 MED1 TNNC1 TNNC1 MYLK2 MYLK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VWA5AVon Willebrand factor A domain containing 5A. (786 aa)
MYL3Myosin light chain 3. (201 aa)
MYH6Myosin heavy chain 6; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
SIRT6Sirtuin 6. (355 aa)
ENSCANP00000038657Fork-head domain-containing protein. (200 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ARID2AT-rich interaction domain 2. (1836 aa)
C10orf113Chromosome 10 open reading frame 113. (152 aa)
GATA4GATA binding protein 4. (236 aa)
POU4F1POU domain protein. (288 aa)
HOPXHOP homeobox. (112 aa)
ENSCANP00000036326Uncharacterized protein. (144 aa)
NEBNebulin. (7557 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
XIRP2Xin actin binding repeat containing 2. (3549 aa)
TBX20T-box transcription factor 20. (447 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2015 aa)
COL11A1Collagen type XI alpha 1 chain. (1764 aa)
LRP2LDL receptor related protein 2. (4655 aa)
TNNI1Troponin I1, slow skeletal type. (187 aa)
EGLN1Fe2OG dioxygenase domain-containing protein. (128 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TBX18T-box transcription factor 18. (607 aa)
LOC105511833Uncharacterized protein. (234 aa)
OBSL1Obscurin like 1. (1672 aa)
TTNTitin. (32000 aa)
SHOX2Short stature homeobox 2. (221 aa)
ENSCANP00000030255Fork-head domain-containing protein. (189 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1246 aa)
PROX1Prospero homeobox 1. (737 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
LOC105515123Uncharacterized protein. (307 aa)
SLC8A1Solute carrier family 8 member A1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (973 aa)
SGCBSarcoglycan beta. (315 aa)
PLECPlectin. (4128 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WT1WT1 transcription factor. (517 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (782 aa)
NRG1Neuregulin 1. (645 aa)
RARBRetinoic acid receptor beta. (448 aa)
NOTCH1Notch receptor 1. (2559 aa)
MYOCDMyocardin. (923 aa)
NPPANatriuretic peptide A. (153 aa)
SRFSerum response factor. (406 aa)
HAND1Heart and neural crest derivatives expressed 1. (215 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (635 aa)
TAZTafazzin family protein; Some isoforms may be involved in cardiolipin metabolism. (295 aa)
NRAPNebulin related anchoring protein. (1730 aa)
IFT20Intraflagellar transport 20. (141 aa)
MYH11Myosin heavy chain 11; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1670 aa)
PTCD2Pentatricopeptide repeat domain 2. (388 aa)
TNNT2Troponin T2, cardiac type. (302 aa)
ALPK2Alpha kinase 2. (2160 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
MEF2AMyocyte enhancer factor 2A. (512 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (370 aa)
MAP2K4Mitogen-activated protein kinase kinase 4; Belongs to the protein kinase superfamily. (373 aa)
NEBLNebulette. (1014 aa)
CBY1Chibby family member 1, beta catenin antagonist. (169 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2549 aa)
GATA5GATA binding protein 5. (334 aa)
NPPBNatriuretic peptide B. (134 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (337 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (815 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (706 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CXADRCXADR Ig-like cell adhesion molecule. (365 aa)
DIPK2ADivergent protein kinase domain 2A. (430 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1137 aa)
TBX5T-box transcription factor 5. (518 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
BVESBlood vessel epicardial substance. (360 aa)
ADRA1AAdrenoceptor alpha 1A. (466 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
RARARetinoic acid receptor alpha. (478 aa)
ADAMTS9ADAM metallopeptidase with thrombospondin type 1 motif 9. (1935 aa)
TGFBR3Transforming growth factor beta receptor 3. (860 aa)
MAML1Mastermind like transcriptional coactivator 1. (924 aa)
TBX3T-box transcription factor 3. (743 aa)
ALPK3Alpha kinase 3. (1871 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
HEG1Heart development protein with EGF like domains 1. (1274 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
FOXH1Forkhead box H1. (366 aa)
SGCZSarcoglycan zeta. (312 aa)
DSG2Desmoglein 2. (1118 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1215 aa)
TENM4Teneurin transmembrane protein 4. (2769 aa)
FHOD3Formin homology 2 domain containing 3. (1567 aa)
AKAP13A-kinase anchoring protein 13. (2812 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (403 aa)
SORBS2Sorbin and SH3 domain containing 2. (1199 aa)
MYBPC3Myosin binding protein C, cardiac. (1306 aa)
TNNI3Troponin I3, cardiac type. (210 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1144 aa)
NKX2-6NK2 homeobox 6. (301 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
DSPDesmoplakin. (2510 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
NOTCH2Notch receptor 2. (2471 aa)
NKX2-5NK2 homeobox 5. (324 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
FHL2Four and a half LIM domains 2. (363 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1935 aa)
MYO18BMyosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2565 aa)
IRX3Iroquois homeobox 3. (411 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
MSCMusculin. (206 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (821 aa)
KDM6BLysine demethylase 6B. (1689 aa)
ENSCANP00000006830Protein kinase domain-containing protein. (373 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
SMAD7Mothers against decapentaplegic homolog. (431 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (489 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (582 aa)
GATA6GATA binding protein 6. (462 aa)
ZIC3Zic family member 3. (466 aa)
SGCDSarcoglycan delta. (290 aa)
TCAPTitin-cap. (167 aa)
TSC1TSC complex subunit 1. (1164 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
TBX2T-box transcription factor 2. (590 aa)
RYR2Ryanodine receptor 2. (4920 aa)
GJB6Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (261 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
NDRG4NDRG family member 4. (378 aa)
ACTN2Actinin alpha 2. (781 aa)
LRRC10Leucine rich repeat containing 10. (279 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ENGEndoglin. (658 aa)
MYL10Myosin light chain 10. (225 aa)
PDLIM5PDZ and LIM domain 5. (566 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2344 aa)
MYL2Myosin light chain 2. (166 aa)
MAPK11Mitogen-activated protein kinase. (306 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (308 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (524 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
PKP2Plakophilin 2. (882 aa)
SGCGSarcoglycan gamma. (295 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1576 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (161 aa)
MYLK2Myosin light chain kinase 2. (595 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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