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MMP14 MMP14 GNA13 GNA13 PKD1 PKD1 ESRP2 ESRP2 CASR CASR ESR1 ESR1 GZF1 GZF1 NRP1 NRP1 DLG1 DLG1 ENSCANP00000034283 ENSCANP00000034283 HS3ST3B1 HS3ST3B1 CITED1 CITED1 LEF1 LEF1 EDN1 EDN1 MED1 MED1 DDR1 DDR1 SPRY1 SPRY1 PKD2 PKD2 WNT9B WNT9B PPP1CA PPP1CA ENG ENG FGF1 FGF1 IHH IHH TCF21 TCF21 FOXA1 FOXA1 NRARP NRARP ENSCANP00000003346 ENSCANP00000003346 VDR VDR DLG5 DLG5 TGFBR2 TGFBR2 BCL2 BCL2 TBX2 TBX2 PAK1 PAK1 KRAS KRAS HOXA11 HOXA11 PML PML GREB1L GREB1L FGF10 FGF10 DCHS1 DCHS1 TGFB1 TGFB1 FGF8 FGF8 WNT1 WNT1 DSPP DSPP HOXA5 HOXA5 NKX3-1 NKX3-1 LAMA1 LAMA1 TMEM59L TMEM59L ADAMTS16 ADAMTS16 PBX1 PBX1 ENSCANP00000010884 ENSCANP00000010884 KDM5B KDM5B BTRC BTRC RDH10 RDH10 PTCH1 PTCH1 CTNNB1 CTNNB1 LAMA5 LAMA5 AR AR CSF1 CSF1 ACVR1 ACVR1 BMP2 BMP2 GDF7 GDF7 BMP4 BMP4 DLL4 DLL4 TBX3 TBX3 CSMD2 CSMD2 SEMA3E SEMA3E YAP1 YAP1 GLI3 GLI3 GDF2 GDF2 PAX2 PAX2 CLIC4 CLIC4 EYA1 EYA1 SFRP2 SFRP2 NFATC4 NFATC4 PPP3R1 PPP3R1 FGFR2 FGFR2 TBX20 TBX20 FGF2 FGF2 EPHA2 EPHA2 ENSCANP00000033948 ENSCANP00000033948 TIE1 TIE1 GDNF GDNF KDR KDR WNT5A WNT5A ENSCANP00000032633 ENSCANP00000032633 SHH SHH COL4A1 COL4A1 CSMD1 CSMD1 ENSCANP00000030255 ENSCANP00000030255 HHIP HHIP RBM15 RBM15 SMAD4 SMAD4 CTNNBIP1 CTNNBIP1 SPRY2 SPRY2 PLEKHH1 PLEKHH1 WT1 WT1 RSPO2 RSPO2 NOTCH1 NOTCH1 WNT4 WNT4 SRF SRF SALL1 SALL1 PGF PGF HS3ST3A1 HS3ST3A1 CTSH CTSH TIMELESS TIMELESS EXT1 EXT1 CELSR1 CELSR1 BMP7 BMP7 MET MET GREB1 GREB1 SIX1 SIX1 MKS1 MKS1 EDNRA EDNRA NOTCH4 NOTCH4 PKHD1 PKHD1 WNT6 WNT6 PPP3R2 PPP3R2 SLIT2 SLIT2 CTSZ CTSZ DAG1 DAG1 EGF EGF SRC SRC PLXND1 PLXND1 FOXF1 FOXF1 LRP5 LRP5 AREG AREG GLI2 GLI2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MMP14Matrix metallopeptidase 14. (582 aa)
GNA13G protein subunit alpha 13. (282 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4053 aa)
ESRP2Epithelial splicing regulatory protein 2. (720 aa)
CASRCalcium sensing receptor. (1088 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
GZF1GDNF inducible zinc finger protein 1. (711 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (926 aa)
ENSCANP00000034283Dilute domain-containing protein. (319 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (391 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (219 aa)
LEF1Lymphoid enhancer binding factor 1. (399 aa)
EDN1Endothelin 1. (211 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1576 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (894 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (780 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (329 aa)
ENGEndoglin. (658 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
IHHIndian hedgehog signaling molecule. (373 aa)
TCF21Transcription factor 21. (179 aa)
FOXA1Forkhead box A1. (447 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
ENSCANP00000003346Uncharacterized protein. (126 aa)
VDRVitamin D receptor. (477 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1896 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (592 aa)
BCL2BCL2 apoptosis regulator. (239 aa)
TBX2T-box transcription factor 2. (590 aa)
PAK1Non-specific serine/threonine protein kinase. (555 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
HOXA11Homeobox A11. (312 aa)
PMLPromyelocytic leukemia. (882 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1924 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
DCHS1Dachsous cadherin-related 1. (3302 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
DSPPDentin sialophosphoprotein. (1113 aa)
HOXA5Homeobox A5. (270 aa)
NKX3-1NK3 homeobox 1. (232 aa)
LAMA1Laminin subunit alpha 1. (3054 aa)
TMEM59LTransmembrane protein 59 like. (286 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1200 aa)
PBX1PBX homeobox 1. (430 aa)
ENSCANP00000010884Uncharacterized protein. (338 aa)
KDM5BLysine demethylase 5B. (1487 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (527 aa)
RDH10Retinol dehydrogenase 10. (176 aa)
PTCH1Patched 1. (1449 aa)
CTNNB1Catenin beta 1. (781 aa)
LAMA5Laminin subunit alpha 5. (3457 aa)
ARAndrogen receptor. (897 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (551 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
GDF7Growth differentiation factor 7. (366 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
TBX3T-box transcription factor 3. (743 aa)
CSMD2CUB and Sushi multiple domains 2. (3537 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
YAP1Yes associated protein 1. (479 aa)
GLI3GLI family zinc finger 3. (1580 aa)
GDF2Growth differentiation factor 2. (429 aa)
PAX2Paired box 2. (388 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
SFRP2Secreted frizzled related protein 2. (295 aa)
NFATC4Nuclear factor of activated T cells 4. (918 aa)
PPP3R1Uncharacterized protein. (189 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
TBX20T-box transcription factor 20. (447 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
EPHA2EPH receptor A2. (976 aa)
ENSCANP00000033948Homeobox domain-containing protein. (141 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
GDNFGlial cell derived neurotrophic factor. (228 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ENSCANP00000032633Uncharacterized protein. (237 aa)
SHHSonic hedgehog signaling molecule. (390 aa)
COL4A1Collagen type IV alpha 1 chain. (1627 aa)
CSMD1CUB and Sushi multiple domains 1. (3565 aa)
ENSCANP00000030255Fork-head domain-containing protein. (189 aa)
HHIPHedgehog interacting protein. (700 aa)
RBM15RNA binding motif protein 15. (980 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CTNNBIP1Catenin beta interacting protein 1. (81 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
PLEKHH1Pleckstrin homology, MyTH4 and FERM domain containing H1. (1364 aa)
WT1WT1 transcription factor. (517 aa)
RSPO2R-spondin 2. (243 aa)
NOTCH1Notch receptor 1. (2559 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
SRFSerum response factor. (406 aa)
SALL1Spalt like transcription factor 1. (1318 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (200 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (235 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (331 aa)
TIMELESSTimeless circadian regulator. (1111 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2704 aa)
BMP7Bone morphogenetic protein 7. (431 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1404 aa)
GREB1Growth regulating estrogen receptor binding 1. (1949 aa)
SIX1SIX homeobox 1. (284 aa)
MKS1MKS transition zone complex subunit 1. (559 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
NOTCH4Notch receptor 4. (2001 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4073 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
PPP3R2Protein phosphatase 3 regulatory subunit B, beta. (174 aa)
SLIT2Slit guidance ligand 2. (1542 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (256 aa)
DAG1Dystroglycan 1. (894 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
SRCTyrosine-protein kinase. (458 aa)
PLXND1Plexin D1. (1736 aa)
FOXF1Forkhead box F1. (351 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
AREGAmphiregulin. (275 aa)
GLI2GLI family zinc finger 2. (1585 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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