STRINGSTRING
EPAS1 EPAS1 CCDC154 CCDC154 IHH IHH LIF LIF VDR VDR ADRB2 ADRB2 PLG PLG LGR4 LGR4 HOXA3 HOXA3 MEF2C MEF2C FGF10 FGF10 NOTCH2 NOTCH2 TGFB1 TGFB1 CAV1 CAV1 RSPO3 RSPO3 FGF8 FGF8 RASSF2 RASSF2 CELA1 CELA1 ACVRL1 ACVRL1 PTK2B PTK2B CTNNB1 CTNNB1 TPH1 TPH1 LIPA LIPA TNFSF11 TNFSF11 DLL4 DLL4 NOS3 NOS3 MITF MITF TIMP1 TIMP1 TPP1 TPP1 ZNF675 ZNF675 TRAF6 TRAF6 EFNA2 EFNA2 SPP2 SPP2 NOL3 NOL3 SEMA3C SEMA3C IL7 IL7 NCDN NCDN EDNRA EDNRA BAK1 BAK1 FLNA FLNA HNF1A HNF1A ATG5 ATG5 EXT1 EXT1 NFKB1 NFKB1 GDF5 GDF5 UMOD UMOD RAB3D RAB3D JAG1 JAG1 CRB1 CRB1 ARG1 ARG1 IGFBP5 IGFBP5 CSPG4 CSPG4 ACVR2B ACVR2B ATP7A ATP7A AXL AXL BAX BAX HIF1A HIF1A SNX10 SNX10 ELF3 ELF3 HTR1B HTR1B AGTR2 AGTR2 PTN PTN P3H4 P3H4 ENSCANP00000030255 ENSCANP00000030255 TGFB3 TGFB3 BMPR2 BMPR2 ACP5 ACP5 TIE1 TIE1 EPHA2 EPHA2 THBS4 THBS4 F2R F2R WNT16 WNT16 CTHRC1 CTHRC1 CHD7 CHD7 LTBP3 LTBP3 CCR2 CCR2 DBH DBH ENSCANP00000038657 ENSCANP00000038657 LRP5 LRP5 BSX BSX IAPP IAPP PTH1R PTH1R TCIRG1 TCIRG1 SRC SRC IL23A IL23A LRRK1 LRRK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EPAS1Endothelial PAS domain protein 1. (869 aa)
CCDC154Coiled-coil domain containing 154. (549 aa)
IHHIndian hedgehog signaling molecule. (373 aa)
LIFLIF interleukin 6 family cytokine. (204 aa)
VDRVitamin D receptor. (477 aa)
ADRB2Adrenoceptor beta 2. (415 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (810 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (932 aa)
HOXA3Homeobox A3. (443 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
NOTCH2Notch receptor 2. (2471 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (179 aa)
RSPO3R-spondin 3. (293 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
RASSF2Ras association domain family member 2. (326 aa)
CELA1Chymotrypsin like elastase 1; Belongs to the peptidase S1 family. (257 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CTNNB1Catenin beta 1. (781 aa)
TPH1Tryptophan hydroxylase 1. (444 aa)
LIPALipase; Belongs to the AB hydrolase superfamily. Lipase family. (399 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (317 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1205 aa)
MITFMelanocyte inducing transcription factor. (526 aa)
TIMP1TIMP metallopeptidase inhibitor 1. (207 aa)
TPP1Tripeptidyl peptidase 1. (563 aa)
ZNF675Uncharacterized protein. (560 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (522 aa)
EFNA2Ephrin A2; Belongs to the ephrin family. (227 aa)
SPP2Secreted phosphoprotein 2. (211 aa)
NOL3Nucleolar protein 3. (266 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (750 aa)
IL7Interleukin 7. (178 aa)
NCDNNeurochondrin. (729 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
FLNAFilamin A. (2647 aa)
HNF1AHNF1 homeobox A. (662 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
NFKB1Nuclear factor kappa B subunit 1. (970 aa)
GDF5Growth differentiation factor 5. (499 aa)
UMODUromodulin. (674 aa)
RAB3DRAB3D, member RAS oncogene family. (219 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1089 aa)
CRB1Crumbs cell polarity complex component 1. (1376 aa)
ARG1Arginase. (322 aa)
IGFBP5Insulin like growth factor binding protein 5. (272 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2324 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (750 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
AXLAXL receptor tyrosine kinase. (894 aa)
BAXBCL2 associated X, apoptosis regulator. (198 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (827 aa)
SNX10Sorting nexin 10. (201 aa)
ELF3E74 like ETS transcription factor 3. (383 aa)
HTR1B5-hydroxytryptamine receptor 1B. (390 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (363 aa)
PTNPleiotrophin. (172 aa)
P3H4Prolyl 3-hydroxylase family member 4 (non-enzymatic). (450 aa)
ENSCANP00000030255Fork-head domain-containing protein. (189 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
BMPR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1030 aa)
ACP5Tartrate-resistant acid phosphatase type 5. (325 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1138 aa)
EPHA2EPH receptor A2. (976 aa)
THBS4Thrombospondin 4. (961 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (413 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
CTHRC1Collagen triple helix repeat containing 1. (147 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2998 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1127 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (374 aa)
DBHDopamine beta-hydroxylase. (620 aa)
ENSCANP00000038657Fork-head domain-containing protein. (200 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1611 aa)
BSXBrain specific homeobox. (232 aa)
IAPPIslet amyloid polypeptide. (86 aa)
PTH1RParathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (592 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
SRCTyrosine-protein kinase. (458 aa)
IL23AInterleukin 23 subunit alpha. (200 aa)
LRRK1Leucine rich repeat kinase 1. (2015 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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