STRINGSTRING
LOC105522577 LOC105522577 LOC105523325 LOC105523325 AGAP2 AGAP2 LRG1 LRG1 FGF9 FGF9 RREB1 RREB1 FGFR2 FGFR2 EGF EGF WNT7A WNT7A PLXNB3 PLXNB3 ENSCANP00000019829 ENSCANP00000019829 IGF1 IGF1 PTPRN PTPRN DLX5 DLX5 CCND1 CCND1 MTA3 MTA3 PKHD1 PKHD1 RUNX2 RUNX2 ZNF703 ZNF703 VIP VIP APLN APLN STAT3 STAT3 HSF4 HSF4 ZNF304 ZNF304 PDPK1 PDPK1 JCAD JCAD CYBA CYBA XBP1 XBP1 B4GALT1 B4GALT1 ITGB3 ITGB3 VEGFD VEGFD MAP2K5 MAP2K5 PGF PGF PROK1 PROK1 MDK MDK ARG1 ARG1 SP1 SP1 TNFAIP3 TNFAIP3 WDR48 WDR48 ATP7A ATP7A NOTCH1 NOTCH1 CYP7B1 CYP7B1 NR4A3 NR4A3 TACR1 TACR1 AKT3 AKT3 WNT3A WNT3A LOC105527575 LOC105527575 HIF1A HIF1A FZD7 FZD7 BTK BTK VEGFA VEGFA GATA2 GATA2 NOD2 NOD2 GHSR GHSR TGFBR1 TGFBR1 MYC MYC PROX1 PROX1 PTN PTN SHH SHH FGF7 FGF7 TNFSF12 TNFSF12 ECM1 ECM1 MST1 MST1 JUN JUN HTRA1 HTRA1 BMPR2 BMPR2 MMP12 MMP12 GRN GRN CCL26 CCL26 WNT5A WNT5A KDR KDR HPN HPN NRP2 NRP2 ENSCANP00000033724 ENSCANP00000033724 SPINK1 SPINK1 SCN5A SCN5A FGF2 FGF2 NODAL NODAL SOX9 SOX9 ST8SIA1 ST8SIA1 REG3G REG3G REG3A REG3A THBS4 THBS4 NRP1 NRP1 LOC105523238 LOC105523238 PRKD2 PRKD2 PRKD1 PRKD1 PPP1R16B PPP1R16B SOX11 SOX11 CCR3 CCR3 ESRP2 ESRP2 IL10 IL10 AGTR1 AGTR1 VEGFB VEGFB CXCL12 CXCL12 PIK3CD PIK3CD FGFR1 FGFR1 EPGN EPGN TP63 TP63 HMX2 HMX2 ID1 ID1 SRSF6 SRSF6 AGGF1 AGGF1 OSR2 OSR2 VASH2 VASH2 AREG AREG OSR1 OSR1 CCL24 CCL24 SIRT6 SIRT6 IL18 IL18 APLNR APLNR SFRP1 SFRP1 CRNN CRNN MED1 MED1 HYAL1 HYAL1 APELA APELA GPBAR1 GPBAR1 F3 F3 SEMA5A SEMA5A FGF1 FGF1 IHH IHH PRKCA PRKCA ITGA4 ITGA4 ENSCANP00000003080 ENSCANP00000003080 NRARP NRARP ZBED9 ZBED9 ENSCANP00000003738 ENSCANP00000003738 NOG NOG ARNT ARNT ODAM ODAM IGF2 IGF2 BAD BAD HRAS HRAS CLDN1 CLDN1 HLX HLX SMO SMO STXBP4 STXBP4 HAS2 HAS2 TGFA TGFA JAML JAML BMP5 BMP5 SIRT1 SIRT1 NKX2-5 NKX2-5 ERBB2 ERBB2 LOC105522005 LOC105522005 FGF10 FGF10 PDX1 PDX1 NOTCH2 NOTCH2 TGFB1 TGFB1 HTR2B HTR2B NKX2-6 NKX2-6 BMP6 BMP6 ENSCANP00000009344 ENSCANP00000009344 ADAM17 ADAM17 ENSCANP00000009841 ENSCANP00000009841 ZNF580 ZNF580 TGM1 TGM1 ACVRL1 ACVRL1 ENSCANP00000010884 ENSCANP00000010884 KDM5B KDM5B CTNNB1 CTNNB1 GHRL GHRL VEGFC VEGFC DLX6 DLX6 AR AR PLCG1 PLCG1 STAT5A STAT5A NR4A1 NR4A1 BMP2 BMP2 RPTOR RPTOR IQGAP3 IQGAP3 BMPR1A BMPR1A MYDGF MYDGF BMP4 BMP4 ENSCANP00000013830 ENSCANP00000013830 ENSCANP00000013994 ENSCANP00000013994 HRH3 HRH3 RESP18 RESP18 AKT1 AKT1 SAAL1 SAAL1 YAP1 YAP1 PDGFB PDGFB EGR3 EGR3 GDF2 GDF2 LACRT LACRT PAX2 PAX2 FLT4 FLT4 RTN4 RTN4 EYA1 EYA1 TCF7L2 TCF7L2 WNT2 WNT2 EMC10 EMC10 EGFR EGFR CDH3 CDH3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC105522577Uncharacterized protein. (399 aa)
LOC105523325Uncharacterized protein. (284 aa)
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (1025 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
RREB1Ras responsive element binding protein 1. (1732 aa)
FGFR2Fibroblast growth factor receptor. (838 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1207 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
PLXNB3Plexin B3. (1913 aa)
ENSCANP00000019829Uncharacterized protein. (98 aa)
IGF1Insulin like growth factor 1. (208 aa)
PTPRNProtein tyrosine phosphatase receptor type N. (979 aa)
DLX5Distal-less homeobox 5. (289 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (295 aa)
MTA3Metastasis associated 1 family member 3. (591 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4073 aa)
RUNX2RUNX family transcription factor 2. (475 aa)
ZNF703Zinc finger protein 703. (567 aa)
VIPVasoactive intestinal peptide. (170 aa)
APLNApelin. (77 aa)
STAT3Signal transducer and activator of transcription. (795 aa)
HSF4HSF_DOMAIN domain-containing protein. (283 aa)
ZNF304Zinc finger protein 304. (707 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (406 aa)
JCADJunctional cadherin 5 associated. (1360 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
XBP1X-box binding protein 1. (204 aa)
B4GALT1Beta-1,4-galactosyltransferase 1. (331 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
MAP2K5Mitogen-activated protein kinase kinase 5; Belongs to the protein kinase superfamily. (448 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (200 aa)
PROK1Prokineticin 1. (105 aa)
MDKUncharacterized protein. (164 aa)
ARG1Arginase. (322 aa)
SP1Sp1 transcription factor. (718 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
WDR48WD repeat domain 48. (677 aa)
ATP7AATPase copper transporting alpha. (1500 aa)
NOTCH1Notch receptor 1. (2559 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (505 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (549 aa)
TACR1Tachykinin receptor 1; Belongs to the G-protein coupled receptor 1 family. (407 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
LOC105527575Uncharacterized protein. (343 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (827 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (557 aa)
BTKTyrosine-protein kinase. (692 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (412 aa)
GATA2GATA binding protein 2. (480 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1040 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (454 aa)
PROX1Prospero homeobox 1. (737 aa)
PTNPleiotrophin. (172 aa)
SHHSonic hedgehog signaling molecule. (390 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TNFSF12TNF superfamily member 12; Belongs to the tumor necrosis factor family. (220 aa)
ECM1Extracellular matrix protein 1. (567 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (246 aa)
HTRA1HtrA serine peptidase 1. (384 aa)
BMPR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1030 aa)
MMP12Matrix metallopeptidase 12. (470 aa)
GRNGranulin precursor. (593 aa)
CCL26C-C motif chemokine. (94 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
HPNHepsin; Belongs to the peptidase S1 family. (417 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (930 aa)
ENSCANP00000033724Uncharacterized protein. (794 aa)
SPINK1Serine peptidase inhibitor, Kazal type 1. (79 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2015 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
NODALNodal growth differentiation factor. (347 aa)
SOX9SRY-box transcription factor 9. (509 aa)
ST8SIA1ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1; Belongs to the glycosyltransferase 29 family. (356 aa)
REG3GRegenerating family member 3 gamma. (169 aa)
REG3ARegenerating family member 3 alpha. (175 aa)
THBS4Thrombospondin 4. (961 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
LOC105523238Uncharacterized protein. (681 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (871 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (832 aa)
PPP1R16BProtein phosphatase 1 regulatory subunit 16B. (567 aa)
SOX11Transcription factor SOX. (372 aa)
CCR3C-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (371 aa)
ESRP2Epithelial splicing regulatory protein 2. (720 aa)
IL10Interleukin 10. (178 aa)
AGTR1Angiotensin II receptor type 1; Belongs to the G-protein coupled receptor 1 family. (394 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (197 aa)
CXCL12C-X-C motif chemokine ligand 12; Belongs to the intercrine alpha (chemokine CxC) family. (140 aa)
PIK3CDPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta; Belongs to the PI3/PI4-kinase family. (1071 aa)
FGFR1Fibroblast growth factor receptor. (815 aa)
EPGNEpithelial mitogen. (154 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (654 aa)
HMX2H6 family homeobox 2. (239 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
SRSF6RRM domain-containing protein. (292 aa)
AGGF1Uncharacterized protein. (710 aa)
OSR2Odd-skipped related transciption factor 2. (418 aa)
VASH2Vasohibin 2. (311 aa)
AREGAmphiregulin. (275 aa)
OSR1Odd-skipped related transcription factor 1. (266 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
SIRT6Sirtuin 6. (355 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
CRNNCornulin. (495 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1576 aa)
HYAL1Hyaluronidase. (450 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
GPBAR1G protein-coupled bile acid receptor 1. (330 aa)
F3Coagulation factor III, tissue factor. (296 aa)
SEMA5ASemaphorin 5A. (1074 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
IHHIndian hedgehog signaling molecule. (373 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1032 aa)
ENSCANP00000003080NDK domain-containing protein; Belongs to the NDK family. (123 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
ZBED9Zinc finger BED-type containing 9. (1325 aa)
ENSCANP00000003738Uncharacterized protein. (247 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (789 aa)
ODAMOdontogenic, ameloblast associated. (281 aa)
IGF2Insulin like growth factor 2. (236 aa)
BADBCL2 associated agonist of cell death. (167 aa)
HRASHRas proto-oncogene, GTPase. (189 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
HLXH2.0 like homeobox. (494 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (768 aa)
STXBP4Syntaxin binding protein 4. (553 aa)
HAS2Hyaluronan synthase 2. (552 aa)
TGFATransforming growth factor alpha. (166 aa)
JAMLJunction adhesion molecule like. (394 aa)
BMP5Bone morphogenetic protein 5. (454 aa)
SIRT1Sirtuin 1. (600 aa)
NKX2-5NK2 homeobox 5. (324 aa)
ERBB2Receptor protein-tyrosine kinase. (1259 aa)
LOC105522005Uncharacterized protein. (138 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PDX1Pancreatic and duodenal homeobox 1. (283 aa)
NOTCH2Notch receptor 2. (2471 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (336 aa)
HTR2B5-hydroxytryptamine receptor 2B. (481 aa)
NKX2-6NK2 homeobox 6. (301 aa)
BMP6Bone morphogenetic protein 6. (331 aa)
ENSCANP00000009344Uncharacterized protein. (627 aa)
ADAM17ADAM metallopeptidase domain 17. (824 aa)
ENSCANP00000009841NDK domain-containing protein. (96 aa)
ZNF580Zinc finger protein 580. (90 aa)
TGM1Transglutaminase 1. (808 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
ENSCANP00000010884Uncharacterized protein. (338 aa)
KDM5BLysine demethylase 5B. (1487 aa)
CTNNB1Catenin beta 1. (781 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (459 aa)
DLX6Distal-less homeobox 6. (293 aa)
ARAndrogen receptor. (897 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1278 aa)
STAT5ASignal transducer and activator of transcription. (789 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (651 aa)
BMP2Bone morphogenetic protein 2. (396 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1331 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1632 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
MYDGFMyeloid derived growth factor. (159 aa)
BMP4Bone morphogenetic protein 4. (408 aa)
ENSCANP00000013830Uncharacterized protein. (148 aa)
ENSCANP00000013994Nucleoside diphosphate kinase. (177 aa)
HRH3Histamine receptor H3; Belongs to the G-protein coupled receptor 1 family. (416 aa)
RESP18Regulated endocrine specific protein 18. (228 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (488 aa)
SAAL1Serum amyloid A like 1. (473 aa)
YAP1Yes associated protein 1. (479 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (220 aa)
EGR3Early growth response 3. (387 aa)
GDF2Growth differentiation factor 2. (429 aa)
LACRTLacritin. (137 aa)
PAX2Paired box 2. (388 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1342 aa)
RTN4Reticulon. (986 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (592 aa)
TCF7L2Transcription factor 7 like 2. (577 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
EMC10ER membrane protein complex subunit 10. (345 aa)
EGFRReceptor protein-tyrosine kinase. (1188 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (770 aa)
Your Current Organism:
Colobus angolensis
NCBI taxonomy Id: 336983
Other names: C. angolensis palliatus, Colobus angolensis palliatus
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